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    Retinoid X receptor-interacting polypeptides and related molecules and methods
    151.
    发明授权
    Retinoid X receptor-interacting polypeptides and related molecules and methods 有权
    类视黄醇X受体相互作用多肽及相关分子及方法

    公开(公告)号：US07115711B1

    公开(公告)日：2006-10-03

    申请号：US09365576

    申请日：1999-08-02

    Applicant: David Moore ,  Wongi Seol ,  Hueng-Sik Choi

    Inventor： David Moore ,  Wongi Seol ,  Hueng-Sik Choi

    IPC: C07K14/00

    CPC classification number: C07K14/72 ,  C07K14/47 ,  C07K14/70567 ,  C07K2319/00

    Abstract: Disclosed is a method for determining whether a test protein is capable of interacting with a retinoid X receptor protein. The method involves: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including a retinoid X receptor protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the test protein covalently bonded to a gene activating moiety; and (b) determining whether the test protein increases expression of the reporter gene as an indication of its ability to interact with the retinoid X receptor protein. Also disclosed is purified DNA encoding retinoid X receptor-interacting proteins and the polypeptides expressed from such DNA.

    Abstract translation: 公开了一种用于确定测试蛋白是否能够与类视黄醇X受体蛋白质相互作用的方法。 该方法包括：（a）提供宿主细胞，其包含（i）可操作地连接到蛋白质结合位点的报告基因; （ii）表达第一融合蛋白的第一融合基因，所述第一融合蛋白包括与结合部分共价结合的类视黄醇X受体蛋白，所述结合部分能够特异性结合所述蛋白质结合位点; 和（iii）表达第二融合蛋白的第二融合基因，所述第二融合蛋白包括与基因活化部分共价结合的所述测试蛋白; 和（b）确定测试蛋白是否增加了报告基因的表达，作为其与类视黄醇X受体蛋白质相互作用的指示。 还公开了编码类视黄醇X受体相互作用蛋白质的纯化DNA和从该DNA表达的多肽。

    Hemispherical high bandwidth mechanical interface for computer systems
    152.
    发明申请
    Hemispherical high bandwidth mechanical interface for computer systems 有权
    用于计算机系统的半球形高带宽机械接口

    公开(公告)号：US20060194180A1

    公开(公告)日：2006-08-31

    申请号：US11412290

    申请日：2006-04-26

    Applicant: JoeBen Bevirt ,  David Moore ,  John Norwood ,  Louis Rosenberg ,  Mike Levin

    Inventor： JoeBen Bevirt ,  David Moore ,  John Norwood ,  Louis Rosenberg ,  Mike Levin

    IPC: G09B23/28

    CPC classification number: G09B23/285 ,  A61B34/70 ,  A61B34/71 ,  A61B34/76 ,  A61B2034/742 ,  G05G9/04 ,  G06F3/016 ,  G06F3/0338 ,  G06F3/05

    Abstract: A mechanical interface for providing high bandwidth and low noise mechanical input and output for computer systems. A gimbal mechanism includes multiple members that are pivotably coupled to each other to provide two revolute degrees of freedom to a user manipulatable about a pivot point located remotely from the members at about an intersection of the axes of rotation of the members. A linear axis member, coupled to the user object, is coupled to at least one of the members, extends through the remote pivot point and is movable in the two rotary degrees of freedom and a third linear degree of freedom. Transducers associated with the provided degrees of freedom include sensors and actuators and provide an electromechanical interface between the object and a computer. Capstan band drive mechanisms transmit forces between the transducers and the object and include a capstan and flat bands, where the flat bands transmit motion and force between the capstan and interface members. Applications include simulations of medical procedures, e.g. epidural anesthesia, where the user object is a needle or other medical instrument, or other types of simulations or games.

    Abstract translation: 用于为计算机系统提供高带宽和低噪声机械输入和输出的机械接口。 万向节机构包括多个构件，其可枢转地彼此联接，以向围绕位于构件旋转轴线的交叉点处远离构件的枢轴点操纵的用户提供两个旋转自由度。 耦合到用户物体的线性轴构件联接到至少一个构件，延伸穿过远程枢轴点并且可以在两个旋转自由度和第三线性自由度中移动。 与提供的自由度相关联的传感器包括传感器和致动器，并且在对象和计算机之间提供机电接口。 绞盘带驱动机构在换能器和物体之间传递力并且包括绞盘和扁平带，其中扁平带在绞盘和接口构件之间传递运动和力。 应用包括医疗程序的模拟，例如 硬膜外麻醉，其中用户对象是针或其他医疗器械，或其他类型的模拟或游戏。

    Modular networked sensor assembly
    154.
    发明申请
    Modular networked sensor assembly 有权
    模块化网络传感器组件

    公开(公告)号：US20060162364A1

    公开(公告)日：2006-07-27

    申请号：US11043317

    申请日：2005-01-26

    Applicant: Chris Felcman ,  David Moore ,  Gary Landrum

    Inventor： Chris Felcman ,  David Moore ,  Gary Landrum

    IPC: F25D17/00 ,  F25B41/00 ,  F25D23/12

    CPC classification number: H05K7/20736 ,  H05K7/20836 ,  Y10T29/49002

    Abstract: The invention provides a modular network sensor assembly operable to sense environmental conditions at a computer or equipment rack. The network sensor assembly includes a flexible body operable to be folded along a central fold line. The central fold line separates the flexible body into a first panel and second panel. A number of mounting tabs are hingedly attached to either the first panel or second panel. These mounting tabs are operable to secure the network assembly to the computer rack. A number of sensor tabs are located along the central fold line. Addressable sensors capable of sensing environmental conditions are positioned proximate to the sensor tabs, and communicatively coupled to a common bus. A memory device is also communicatively coupled to the common bus and is operable to store configuration information and data associated with the sensed environmental conditions sampled by the addressable sensors.

    Abstract translation: 本发明提供了一种可操作以感测计算机或设备机架上的环境条件的模块化网络传感器组件。 网络传感器组件包括可操作以沿着中心折叠线折叠的柔性主体。 中心折线将柔性体分为第一面板和第二面板。 多个安装片铰接地连接到第一面板或第二面板上。 这些安装接头可操作以将网络组件固定到计算机机架上。 沿着中心折叠线设置多个传感器片。 能够感测环境条件的可寻址传感器位于传感器接头附近，并且通信地耦合到公共总线。 存储器设备还通信地耦合到公共总线，并且可操作地存储与由可寻址传感器采样的感测到的环境条件相关联的配置信息和数据。

    Computer based plan design and sales method
    156.
    发明授权
    Computer based plan design and sales method 有权
    基于计算机的计划设计和销售方法

    公开(公告)号：US07019759B1

    公开(公告)日：2006-03-28

    申请号：US09567185

    申请日：2000-05-09

    Applicant: David Moore ,  Sara Warner-Phillips ,  Jason Mark ,  Robert Archer ,  Ryan Moore

    Inventor： David Moore ,  Sara Warner-Phillips ,  Jason Mark ,  Robert Archer ,  Ryan Moore

    IPC: G09G5/00 ,  G06F9/00

    CPC classification number: G06T11/00 ,  G06Q30/0621

    Abstract: A method enables online purchase of customizable home construction plans. The method includes accessing a web based software package, customizing the home, and ordering the construction plans. The software package is a second aspect. The software allows the consumer to select different predefined features and add them to a stock floor plan. The selection of different features enables the customization of the home plan. The features selected are displayed to the consumer through a series of layers. The layers are superimposed on each other according to a predefined logic so that the consumer views what the home actually will look like rather an amalgamation of pieces. When the consumer is satisfied with the customized plan, the consumer orders formal plans and construction plans are sent to the consumer.

    Abstract translation: 一种方法可以在线购买可定制的家庭建筑计划。 该方法包括访问基于Web的软件包，定制家庭和订购施工计划。 软件包是第二个方面。 该软件允许消费者选择不同的预定义功能并将其添加到库存平面图。 选择不同的功能可以自定义家庭计划。 所选的功能通过一系列图层显示给消费者。 这些层根据预定义的逻辑叠加在一起，使得消费者观察家庭实际上将看起来像什么，而不是合并的片段。 当消费者对定制计划感到满意时，消费者将正式的计划和施工计划送达消费者。

    Differential expression of molecules associated with acute stroke
    157.
    发明申请
    Differential expression of molecules associated with acute stroke 有权
    与急性中风相关的分子的差异表达

    公开(公告)号：US20060046259A1

    公开(公告)日：2006-03-02

    申请号：US11155835

    申请日：2005-06-17

    Applicant: Alison Baird ,  David Moore ,  Ehud Goldin

    Inventor： Alison Baird ,  David Moore ,  Ehud Goldin

    IPC: C12Q1/68 ,  G01N33/00

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

    Abstract: Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.

    Abstract translation: 提供了用于评估中风的方法，例如用于确定受试者是否具有缺血性中风，确定患有缺血性中风的受试者的严重性或可能的神经恢复，以及确定已经具有缺血性卒中的受试者的治疗方案 缺血性中风，以及可用于实施该方法的阵列和试剂盒。 在具体实例中，该方法包括筛选缺血性卒中相关基因（或蛋白质）中的表达，例如白血细胞活化和分化基因（或蛋白质），与缺氧有关的基因（或蛋白质），参与的基因（或蛋白质） 血管修复和与特异性外周血单核细胞（PBMC）相关的基因（或蛋白质）对改变的脑微环境的反应。 还提供了鉴定改变缺血性卒中相关分子的活性（例如表达）的一种或多种试剂的方法。

    Adapter for a manually operated dispensing device of containers of liquid
    158.
    发明授权
    Adapter for a manually operated dispensing device of containers of liquid 有权
    用于液体容器的手动分配装置的适配器

    公开(公告)号：US06974055B2

    公开(公告)日：2005-12-13

    申请号：US10297377

    申请日：2001-05-31

    Applicant: David Moore ,  Reinhard Neuhaus ,  Ralf Jordan ,  Detlef Schmitz ,  Bernhard Jasper ,  Peter J. Walters

    Inventor： David Moore ,  Reinhard Neuhaus ,  Ralf Jordan ,  Detlef Schmitz ,  Bernhard Jasper ,  Peter J. Walters

    IPC: B05B11/00 ,  B65D83/14 ,  G01F11/06

    CPC classification number: B65D83/36 ,  B05B11/0059 ,  B05B11/3018

    Abstract: The invention relates to an adapter (2) for a manually operated dispensing device (120) for a fluid that is/can be pressurized in a container. The dispensing device includes a housing (148) having a passage channel (30). A tubular adapter housing (34) connects the uptake tube (32) and the channel (30) of the housing (148) of the dispensing device (120). The adapter housing (34) has a connecting sleeve (42) for connection to the connecting nipple of the housing (148) and an uptake tube sleeve (44) for connection to the uptake tube (32). There are several inlets (46) for the fluid in the upside down position of the dispensing device. The adapter housing (34) defines at least one section of the inlets. An inlet valve (48) is defined within the adapter housing (34) for releasing the inlets substantially simultaneously when a pressure acts on the fluid in the container in the substantially upside down position of the container. A shut-off valve (50) is positioned inside a large diameter valve chamber (52) of the adapter housing (34), in such a way that the valve (50) can be freely displaced axially between two end positions.

    Abstract translation: 本发明涉及一种用于手动操作的用于可在容器中加压的流体的分配装置（120）的适配器（2）。 分配装置包括具有通道（30）的壳体（148）。 管状适配器壳体（34）连接吸入管（32）和分配装置（120）的壳体（148）的通道（30）。 适配器壳体（34）具有用于连接到壳体（148）的连接接头的连接套筒（42）和用于连接到摄取管（32）的吸管管套筒（44）。 在分配装置的倒置位置中存在用于流体的多个入口（46）。 适配器壳体（34）限定入口的至少一个部分。 入口阀（48）限定在适配器壳体（34）内，用于在容器的基本上倒置的位置上的压力作用于容器中的流体时基本同时地释放入口。 截止阀（50）位于适配器壳体（34）的大直径阀室（52）的内部，使得阀（50）能够在两个端部位置之间轴向自由移位。

    Data collection system having a data collector
    160.
    发明申请
    Data collection system having a data collector 有权
    具有数据采集器的数据采集系统

    公开(公告)号：US20050173549A1

    公开(公告)日：2005-08-11

    申请号：US10772318

    申请日：2004-02-06

    Applicant: Cullen Bash ,  David Moore ,  Chandrakant Patel

    Inventor： Cullen Bash ,  David Moore ,  Chandrakant Patel

    IPC: G05D1/02 ,  G05D23/19 ,  G05D23/00

    CPC classification number: G05D1/0282 ,  G05D1/0225 ,  G05D1/0246 ,  G05D1/0255 ,  G05D23/1932 ,  G05D2201/0207

    Abstract: A system for collecting data in a room. The system includes a plurality of sensor devices positioned at various locations in the room. The sensor devices include a sensor configured to detect at least one condition and a controller configured to control the sensor. The system also includes at least one data storage device configured to store the detected at least one condition and an interface mechanism for enabling communication of the stored at least one condition. The system further includes a data collector for interfacing with the interface mechanism to receive the stored at least one condition from the at least one data storage device.

    Abstract translation: 用于在房间中收集数据的系统。 该系统包括定位在房间中的各个位置处的多个传感器装置。 传感器设备包括被配置为检测至少一个状态的传感器和被配置为控制传感器的控制器。 该系统还包括被配置为存储检测到的至少一个条件的至少一个数据存储设备和用于实现所存储的至少一个条件的通信的接口机制。 该系统还包括数据收集器，用于与接口机构接口以从至少一个数据存储设备接收存储的至少一个条件。

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