公开(公告)号：US10350518B2

公开(公告)日：2019-07-16

申请号：US14839852

申请日：2015-08-28

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen ,  Mikhail Kozlov ,  Herbert Lutz ,  Joseph Parrella ,  Elizabeth M. Goodrich ,  Bala Raghunath

IPC: B01D29/60 ,  B01D29/52 ,  B01D29/90 ,  B01D61/14 ,  B01D63/04 ,  B01D63/12

Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

公开(公告)号：US10207225B2

公开(公告)日：2019-02-19

申请号：US14736646

申请日：2015-06-11

Applicant: EMD Millipore Corporation

Inventor： Herbert Lutz ,  Joseph Parrella ,  Bala Raghunath

IPC: C07K1/34 ,  B01D61/14 ,  B01D61/18 ,  B01D63/08 ,  B01D65/02

Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

公开(公告)号：US10195605B2

公开(公告)日：2019-02-05

申请号：US15161768

申请日：2016-05-23

Applicant: EMD Millipore Corporation

Inventor： Rene Reinbigler ,  Jean-Louis Weissenbach

IPC: B29C49/00 ,  B01L3/00 ,  B29C33/02 ,  B29C49/48 ,  A61L2/00 ,  C12M1/00 ,  B29C65/02 ,  B29C49/02 ,  B29L31/00 ,  B29K23/00 ,  B29L9/00

Abstract: The method comprises the step of forming pipes (12) by clamping a bag between shells (13, 14) and by injecting an inflating agent via an inflating connector.The circuit comprises a bag (126) and a press (10) comprising two shells (13, 14) clamping said bag in a state in which pipes (12) are formed between the films (25, 26) of the bag.

公开(公告)号：US09943616B2

公开(公告)日：2018-04-17

申请号：US15691369

申请日：2017-08-30

Applicant: EMD Millipore Corporation

Inventor： Mikhail Kozlov ,  Wilson Moya ,  Gabriel Tkacik

IPC: B01D39/16 ,  A61L2/00 ,  B01D67/00 ,  B01D69/00 ,  C02F1/44

CPC classification number: A61L2/0017 ,  B01D39/1623 ,  B01D67/0004 ,  B01D67/002 ,  B01D69/00 ,  B01D2239/025 ,  B01D2323/39 ,  C02F1/444 ,  C02F2303/04

Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.

公开(公告)号：US09910041B2

公开(公告)日：2018-03-06

申请号：US14891727

申请日：2014-04-04

Applicant: EMD Millipore Corporation

Inventor： Matthew T. Stone ,  Ushma Mehta ,  Damon Asher ,  Patricia Greenhalgh

IPC: C07K16/00 ,  C07K1/36 ,  C07D471/02 ,  C07K1/16 ,  C07K1/18 ,  G01N33/569 ,  C07K1/20 ,  C07K1/22 ,  C12Q1/04 ,  C12Q1/06

CPC classification number: G01N33/56983 ,  C07K1/20 ,  C07K1/22 ,  C07K16/00 ,  C12Q1/04 ,  C12Q1/06 ,  G01N2333/015 ,  G01N2333/15

Abstract: The present invention provides methods for determining whether activated carbon can be used for removing viruses or a certain virus from a sample containing a target protein.

公开(公告)号：US09908086B2

公开(公告)日：2018-03-06

申请号：US14665854

申请日：2015-03-23

Applicant: EMD Millipore Corporation

Inventor： Gabriel Tkacik ,  Philip Goddard ,  Willem Kools ,  Nitin Satav

IPC: B01D69/12 ,  B01D67/00 ,  B01D61/14 ,  B01D71/34 ,  B01D71/68 ,  C07K1/34

CPC classification number: B01D69/12 ,  B01D61/145 ,  B01D67/0013 ,  B01D67/0016 ,  B01D67/0018 ,  B01D71/34 ,  B01D71/68 ,  B01D2323/12 ,  B01D2323/42 ,  B01D2325/022 ,  C07K1/34

Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.

公开(公告)号：US09889969B2

公开(公告)日：2018-02-13

申请号：US14282831

申请日：2014-05-20

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  David DeCoste

IPC: G06K19/06 ,  B65D25/20 ,  B65D75/56 ,  B65D75/58 ,  G06K7/10 ,  B31D1/02 ,  B65D33/00 ,  B31B50/81

CPC classification number: B65D25/205 ,  B31B50/81 ,  B31D1/028 ,  B65D33/004 ,  B65D75/566 ,  B65D75/5877 ,  B65D2203/10 ,  G06K7/10237 ,  Y10T29/49016 ,  Y10T156/10

Abstract: The present invention provides a process for incorporating a wireless device into a plastic container as part of the steps of manufacturing the container. The plastic container can be a flexible plastic bag and are formed of one or more sheets, generally two or more sheets of plastic film or a rigid plastic container such as a tub or tote. The bags are formed by sealing together adjacent edge portions of each film layer. One embodiment of the present invention is to incorporate a wireless device between the edge portions of the film(s) before or during sealing so that the wireless device becomes permanently sealed into the film material but is isolated from both the bag interior and the outside environment. Another embodiment is to incorporate the wireless device onto or into a plastic component that is sealed to the container, such as a nipple or port, so that the wireless device becomes permanently sealed to the container but is isolated from both the container interior and the outside environment.

公开(公告)号：US09809799B2

公开(公告)日：2017-11-07

申请号：US14390924

申请日：2013-06-13

Applicant: EMD Millipore Corporation

Inventor： Alex Xenopoulos

IPC: C12N7/00 ,  C07K1/16 ,  C07K1/36

CPC classification number: C12N7/00 ,  C07K1/16 ,  C07K1/36 ,  C12N2740/10061

Abstract: The present application relates to novel and improved methods of achieving virus inactivation during a protein purification process.

公开(公告)号：US09744507B2

公开(公告)日：2017-08-29

申请号：US14440376

申请日：2013-11-05

Applicant: EMD Millipore Corporation

Inventor： Martin Morrissey ,  Brian Pereira

IPC: B01F15/00 ,  B01F13/08 ,  C12M1/00 ,  C12M1/06 ,  B01F7/00

CPC classification number: B01F15/0085 ,  B01F7/00241 ,  B01F13/0827 ,  B01F15/00487 ,  B01F2215/0034 ,  B01F2215/0073 ,  C12M23/14 ,  C12M27/02

Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.

公开(公告)号：US09731288B2

公开(公告)日：2017-08-15

申请号：US14940864

申请日：2015-11-13

Applicant: EMD Millipore Corporation

Inventor： Jad Jaber ,  Wilson Moya ,  James Hamzik ,  Arezki Boudif ,  Yu Zhang ,  Neil Soice ,  John Charkoudian ,  Nripen Singh

IPC: C07K1/30 ,  B01J41/14 ,  C07K1/32 ,  C08F8/00 ,  C08F8/02 ,  C07K16/00 ,  C08F126/02 ,  B01J41/12

CPC classification number: B01J41/14 ,  B01J41/13 ,  C07K1/30 ,  C07K1/32 ,  C07K16/00 ,  C07K2317/10 ,  C08F8/00 ,  C08F8/02 ,  C08F126/02 ,  C08F26/02

Abstract: The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.