公开(公告)号：US20210324431A1

公开(公告)日：2021-10-21

申请号：US17169845

申请日：2021-02-08

Applicant: Genomatica, Inc.

Inventor： Grace J. LEE ,  John HALIBURTON ,  Zhihao HU ,  Andreas W. SCHIRMER ,  Kevin HOLDEN

IPC: C12P7/64 ,  C12N9/10 ,  C12N9/16 ,  C12N9/04 ,  C12N9/18 ,  C12N9/12 ,  C12N9/90 ,  C12N9/88 ,  C07C53/126 ,  C07C57/03

Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.

公开(公告)号：US11142756B2

公开(公告)日：2021-10-12

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Donald E. Trimbur ,  Andreas W. Schirmer ,  Cindy Chang ,  Behnaz Behrouzian ,  Jessica Winger

IPC: C12N15/63 ,  C12N15/70 ,  C12N9/88 ,  C12N1/21 ,  C07K14/245 ,  C12P7/64 ,  C12N9/00 ,  C12N15/67

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US11085015B2

公开(公告)日：2021-08-10

申请号：US15585078

申请日：2017-05-02

Applicant: Genomatica, Inc.

Inventor： Priti Pharkya ,  Anthony P. Burgard ,  Stephen J. Van Dien ,  Robin E. Osterhout ,  Mark J. Burk ,  John D. Trawick ,  Michael P. Kuchinskas ,  Brian Steer

IPC: C12P7/42 ,  C12P7/18 ,  C12N1/20 ,  C12N1/14 ,  C12N1/16 ,  C12N9/18 ,  C12N15/52 ,  C12N15/63 ,  C07C31/20 ,  C07C59/01 ,  C08G18/28 ,  C08G18/32 ,  C08G63/06 ,  C08G63/16 ,  C08G63/181 ,  C08G69/02

Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.

公开(公告)号：US11053184B2

公开(公告)日：2021-07-06

申请号：US14773149

申请日：2014-03-07

Applicant: GENOMATICA, INC.

Inventor： Myong K. Ko ,  Haibo Wang ,  Patricia J. Cole ,  Perry Y. Liao ,  Simon Li

IPC: C07C29/88 ,  C07C29/17

Abstract: The disclosure relates to downstream processing of fatty alcohol (FALC) and provides a novel purification method that provides FALC at high purity and yield.

公开(公告)号：US11034937B2

公开(公告)日：2021-06-15

申请号：US16414550

申请日：2019-05-16

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Elizabeth J. Clarke ,  Eli S. Groban ,  Vikranth Arlagadda ,  Sungwon Lee ,  Xuezhi Li ,  Zhihao Hu ,  Baolong Zhu

IPC: C12P7/04 ,  C12N9/02 ,  C12P7/64

Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.

公开(公告)号：US20210171459A1

公开(公告)日：2021-06-10

申请号：US16932405

申请日：2020-07-17

Applicant: Genomatica, Inc.

Inventor： Rudolf Philippus Maria Guit ,  Thomas Van Der Does ,  Lourina Madeleine Raamsdonk

IPC: C07D201/08 ,  C07D223/10 ,  C07D201/16 ,  C08G69/16

Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.

公开(公告)号：US11008597B2

公开(公告)日：2021-05-18

申请号：US15301754

申请日：2015-04-10

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Andreas W. Schirmer ,  Myong Ko ,  Haibo Wang

IPC: C12P17/08 ,  C12P17/04 ,  C12P7/44 ,  C12P7/42

Abstract: The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.

公开(公告)号：US20210101855A1

公开(公告)日：2021-04-08

申请号：US16498313

申请日：2018-03-29

Applicant: Genomatica, Inc.

Inventor： Julia Khandurina ,  Rachel Diane Pacheco ,  Lauri Hannunpoika Suominen ,  Rainer Wagester

IPC: C07C29/80 ,  B01D3/14 ,  C07C29/94 ,  B01D15/36

Abstract: Provided herein are bioderived 1,3-butanediol compositions and systems and processes for producing such bioderived 1,3-butanediol compositions.

公开(公告)号：US10941454B2

公开(公告)日：2021-03-09

申请号：US15578488

申请日：2016-05-26

Applicant: GENOMATICA, INC. ,  BRASKEM S.A.

Inventor： Stephanie J. Culler ,  Robert J. Haselbeck ,  Harish Nagarajan ,  Iuri Estrada Gouvea ,  Daniel Johannes Koch ,  Mateus Schreiner Garcez Lopes ,  Lucas Pedersen Parizzi

IPC: C12N9/88 ,  C12N9/90 ,  C07K16/40 ,  C08F36/06 ,  C12N15/82 ,  C12P5/02 ,  C12P7/16

Abstract: In alternative embodiments, provided are non-natural or genetically engineered vinylisomerase-dehydratase enzymes, including alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases. In alternative embodiments, provided are non-natural or genetically engineered polypeptides having an activity comprising, for example, a vinylisomerase-dehydratase, an alkenol dehydratase, a linalool dehydratase and/or a crotyl alcohol dehydratase activity, or a combination thereof. In alternative embodiments, also provided are non-natural or genetically engineered nucleic acids (polynucleotides) encoding polypeptides described herein, expression or cloning vehicles comprising or having contained therein nucleic acids as described herein, and non-natural or genetically engineered cells comprising or having contained therein nucleic acids as described herein. In alternative embodiments, also provided are methods for making various organic compounds, including methyl vinyl carbinol and butadiene.

公开(公告)号：US10900057B2

公开(公告)日：2021-01-26

申请号：US15039052

申请日：2014-12-05

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Louis G. Hom

IPC: C12P13/00 ,  C12N9/16 ,  C12N9/02 ,  C12N9/10 ,  C12N9/00 ,  C12N9/06

Abstract: The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.