公开(公告)号：US20160023210A1

公开(公告)日：2016-01-28

申请号：US14842339

申请日：2015-09-01

Applicant: TECAN TRADING AG

Inventor： Nico Birkner ,  Thomas Iten ,  Marina Knoppke ,  Markus Wiggli

IPC: B01L3/00 ,  F16K1/32 ,  F16K21/04

CPC classification number: B01L3/523 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/508 ,  B01L3/50825 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/049 ,  F16K1/32 ,  F16K21/04

Abstract: An inlet valve charges an inner chamber with liquid and has a first axis and an inlet opening with a tool that automatically recloses. The inlet valve has a valve body with a blocking element, and a pressing part; a valve space enclosing the valve body at least partly; a spring mechanism and a sealing element. An open passage region opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body of the inlet valve can be brought to an open position by pressing the pressing part against the resistance of the spring mechanism. Chamber systems and sample containers with such inlet valves are also disclosed.

Abstract translation: 入口阀用液体对内腔充电，并且具有第一轴线和具有自动重合闸的工具的入口开口。 入口阀具有带有阻塞元件的阀体和按压部分; 至少部分地封闭阀体的阀门空间; 弹簧机构和密封元件。 开放的通道区域通向按压部分的液体通道并进入阀门空间。 弹簧机构在阀体的关闭位置将阻塞元件的密封表面压靠密封元件。 通过按压按压部件抵抗弹簧机构的阻力，可以使进气阀的阀体进入打开位置。 还公开了具有这种入口阀的室系统和样品容器。

公开(公告)号：US20160018429A1

公开(公告)日：2016-01-21

申请号：US14870673

申请日：2015-09-30

Applicant: TECAN Trading AG

Inventor： Florian REINER ,  Harald GEBETHSROITHER ,  Josef GRASSL

IPC: G01N35/02 ,  G01N21/25 ,  G01N21/64

CPC classification number: G01N35/028 ,  B01L9/52 ,  C12M1/04 ,  C12M41/14 ,  C12M41/16 ,  C12Q1/02 ,  G01J3/12 ,  G01N21/253 ,  G01N21/6452 ,  G01N33/5005 ,  G01N2035/00356 ,  G01N2201/023 ,  G01N2201/0231 ,  G01N2201/0238 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: The invention relates to a microplate reader and a respective method, wherein the microplate reader comprises at least one measuring device and a holding device for accommodating at least one microplate and for positioning the samples-containing wells of this(these) microplate(s) in relation to the at least one measuring device. The at least one measuring device is used for detecting light which is emitted by samples in wells of a microplate inserted in this microplate reader and/or which is influenced by samples transilluminated by light in wells of a microplate inserted in this microplate reader. The microplate reader comprises a control unit for controlling the temperature of a gas atmosphere surrounding the wells containing the samples of microplates used in this microplate reader.

Abstract translation: 本发明涉及一种酶标仪和相应的方法，其中该酶标仪包括至少一个测量装置和用于容纳至少一个微孔板的保持装置，并将该（微）微孔板的含样品的孔定位在 与至少一个测量装置的关系。 所述至少一个测量装置用于检测由插入该酶标板读数器中的微孔板的孔中的样品发出的光，和/或由插入该酶标板读数器中的微板的孔中的光透过的样品影响。 酶标仪包括用于控制包含在该酶标板读数器中使用的微孔板样品的孔周围的气体气氛的温度的控制单元。

公开(公告)号：US20160016170A1

公开(公告)日：2016-01-21

申请号：US14335027

申请日：2014-07-18

Applicant: Tecan Trading AG

Inventor： Tiffany LAY ,  Daniel HOFFMEYER ,  Anne R. KOPF-SILL

IPC: B01L3/00 ,  G01N1/10

CPC classification number: B01L3/502792 ,  B01L3/0275 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2400/0427

Abstract: A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.

Abstract translation: 一种被配置为数字微流体系统的一次性盒，用于在具有盒容纳位置的液体部分中操作样品，并且控制中央控制单元，用于控制位于该位置处的电极阵列的各个电极的选择，并且为多个电极提供用于操纵的各个电压脉冲 液体部分通过电润湿。 所述筒具有疏水性工作表面和具有第二疏水性表面的刚性盖，所述疏水性表面彼此相对并且在平行的平面上被间隔开。 药筒具有多个移液引导件，用于以移液管吸头将液体安全地进入/从间隙排出。 移液引导件中的至少一个提供了通过移液管尖端的相对表面密封地附着的邻接表面，该移液管尖端位于移动孔口处，该移液孔口通过刚性覆盖物，并且构造成防止移液管尖端接触疏水性工作表面。

公开(公告)号：US20150331428A1

公开(公告)日：2015-11-19

申请号：US14710206

申请日：2015-05-12

Applicant: TECAN Trading AG

Inventor： Rainer KERKMANN ,  Pascal STAEHELI ,  Ho THE VINH

IPC: G05D7/06 ,  G05B19/19 ,  G06F3/0484 ,  G01N35/10 ,  G01N35/00

CPC classification number: G05D7/0623 ,  G01N35/00722 ,  G01N35/1009 ,  G01N35/1011 ,  G01N2035/0091 ,  G05B19/19 ,  G05B19/409 ,  G05B2219/2601 ,  G05B2219/40188 ,  G06F3/04842

Abstract: A method for defining an automated process which is to be carried out in a liquid handling system, wherein the liquid handling system comprises an outlet element (e.g. a pipette) for aspirating and/or dispensing a liquid volume, a numerically controlled movement apparatus for carrying out movements in connection with the aspiration/and or dispensing, and a controller for controlling the process, having the following steps: using a graphic user interface in order to enable the user to predetermine parameters which are to be used by the liquid handling system when carrying out one or several substeps of the process, wherein at least a first parameter is dependent on a second parameter in such a way that the first parameter is adjusted automatically by the system if the second parameter changes.

Abstract translation: 一种用于限定要在液体处理系统中进行的自动化过程的方法，其中所述液体处理系统包括用于吸入和/或分配液体体积的出口元件（例如移液管），用于承载的数控运动装置 以及用于控制过程的控制器，具有以下步骤：使用图形用户界面，以便使用户能够预先确定由液体处理系统使用的参数，当时 执行该过程的一个或多个子步骤，其中至少第一参数取决于第二参数，使得如果第二参数改变，则第一参数由系统自动调整。

公开(公告)号：US09140367B2

公开(公告)日：2015-09-22

申请号：US14342997

申请日：2012-08-28

Applicant: Nico Birkner ,  Thomas Iten ,  Marina Knoppke ,  Markus Wiggli

Inventor： Nico Birkner ,  Thomas Iten ,  Marina Knoppke ,  Markus Wiggli

IPC: B01L99/00 ,  F16K1/32 ,  B01L3/00

CPC classification number: B01L3/523 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/508 ,  B01L3/50825 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/049 ,  F16K1/32 ,  F16K21/04

Abstract: An inlet valve charges an inner chamber of a system or sample container with liquid and has a first pipetting axis, an inlet opening, it supplies liquid by a laboratory pipette that is automatically reclosed and also has a valve body with a blocking element, a pressing part and a throat, a valve space enclosing the valve body at least partly near the throat, a spring mechanism and a sealing element. The throat connects the blocking element to the pressing part and has an open passage region which opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body can be brought to an open position by pressing the pressing part against the spring mechanism.

Abstract translation: 入口阀为系统或样品容器的内腔充满液体，并具有第一移液轴线，入口开口，其通过实验室移液管供应液体，其被自动重新闭合并且还具有带有阻塞元件的阀体，按压 部分和喉部，封闭阀体至少部分地靠近喉部的阀门空间，弹簧机构和密封元件。 喉部将阻塞元件连接到按压部分，并且具有通向按压部分的液体通道并进入阀门空间的开放通道区域。 弹簧机构在阀体的关闭位置将阻塞元件的密封表面压靠密封元件。 通过将按压部件压靠在弹簧机构上，能够使阀体处于打开位置。

公开(公告)号：US09120096B2

公开(公告)日：2015-09-01

申请号：US14571914

申请日：2014-12-16

Applicant: TECAN TRADING AG

Inventor： Marc N. Feiglin ,  Joseph A. Mamone ,  Michael Franklin ,  Timothy Francis Lee

IPC: G01N27/447 ,  B01L3/00 ,  B01L3/02 ,  B01F13/00 ,  B01L7/00 ,  C12Q1/68 ,  G01N27/453

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: A biological sample processing system (1) includes a liquid droplet manipulation instrument (20) with an electrode array (21) for inducing a movement of a liquid droplet (19) by electrowetting; a substrate (22); and a control unit (23). An electrode selector (34) of the control unit (23) is configured to individually select and provide each electrode (35) of the electrode array (21) with a voltage. The control unit (23) includes a central processing unit (36) for individually selecting at least one electrode (35) and for providing the selected electrode(s) (35) with an individual voltage pulse. The biological sample processing system (1) also includes a cartridge (40) with a container (2).

Abstract translation: 生物样品处理系统（1）包括具有电极阵列（21）的液滴操作仪器（20），用于通过电润湿来诱导液滴（19）的移动; 衬底（22）; 和控制单元（23）。 控制单元（23）的电极选择器（34）被配置为单独地选择并提供电极阵列（21）的每个电极（35）。 控制单元（23）包括一个中央处理单元（36），用于分别选择至少一个电极（35），并为所选择的电极（35）提供一个单独的电压脉冲。 生物样品处理系统（1）还包括具有容器（2）的盒（40）。

公开(公告)号：US08882982B2

公开(公告)日：2014-11-11

申请号：US13139647

申请日：2009-12-16

Applicant: Marc N. Feiglin

Inventor： Marc N. Feiglin

IPC: G01N27/453 ,  B01L3/00 ,  B01L3/02

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: A biological sample processing system comprises a container for large volume processing, a flat polymer film having a lower surface and a hydrophobic upper surface, which is kept at a distance d to the base side of the container by the protrusions. The distance d defines at least one gap when the container is positioned on the film. A liquid droplet manipulation instrument comprises at least one electrode array for inducing liquid droplet movements; a substrate supporting the at least one electrode array; and a control unit is characterized in that the container and the film are reversibly attached to the liquid droplet manipulation instrument. The system thus enables displacement of at least one liquid droplet from the at least one well through the channel of the container onto the hydrophobic upper surface of the flat polymer film and above the at least one electrode array; wherein the liquid droplet manipulation instrument controls a guided movement of the liquid droplet on the hydrophobic upper surface of the flat polymer film by electrowetting and to process there the biological sample.

Abstract translation: 生物样品处理系统包括用于大体积加工的容器，具有下表面和疏水性上表面的平坦聚合物膜，其通过突起保持在容器底部的距离d处。 当容器位于胶片上时，距离d限定至少一个间隙。 液滴操作仪器包括用于引起液滴运动的至少一个电极阵列; 支撑所述至少一个电极阵列的基板; 并且控制单元的特征在于，容器和膜可逆地附接到液滴操纵仪器。 因此，该系统使得至少一个液滴从至少一个井通过容器的通道移位到平坦聚合物膜的疏水性上表面上并位于至少一个电极阵列上方; 其特征在于，所述液滴操作装置通过电润湿来控制所述液滴在所述平坦聚合物膜的所述疏水性上表面上的引导移动，并在所述生物样品处理。

公开(公告)号：US20140200683A1

公开(公告)日：2014-07-17

申请号：US13739455

申请日：2013-01-11

Applicant: TECAN TRADING AG

Inventor： Mark MA

IPC: G05B15/02

CPC classification number: G05B15/02 ,  B01L3/0293 ,  G01N35/1011 ,  G01N35/109 ,  G01N2035/1076 ,  G05B19/0426 ,  G05B2219/25482

Abstract: A laboratory system and a method for controlling a laboratory system comprises multiple subsystems; each subsystem being configured to receive and carry out a command; and a master control device configured to process command groups and/or command(s) within the same command group simultaneously; to process command groups and/or command(s) of different command groups sequentially; and within a command group, to process command group(s) and/or command(s) grouped into a command group before processing other commands command group(s) and/or command(s).

Abstract translation: 实验室系统和控制实验室系统的方法包括多个子系统; 每个子系统被配置为接收和执行命令; 以及主控制装置，被配置为同时处理同一命令组内的命令组和/或命令; 按顺序处理不同命令组的命令组和/或命令; 并在命令组内处理在处理其他命令组和/或命令之前分组到命令组中的命令组和/或命令。

公开(公告)号：US08658042B2

公开(公告)日：2014-02-25

申请号：US12198210

申请日：2008-08-26

Applicant: Gerhard Fasching ,  Teresa Hruschka ,  Lutz Niggl ,  Patrick Niklaus

Inventor： Gerhard Fasching ,  Teresa Hruschka ,  Lutz Niggl ,  Patrick Niklaus

IPC: B01L3/00 ,  G01N31/20 ,  B03C1/30

CPC classification number: B03C1/288 ,  B01L3/5085 ,  B01L9/523 ,  B01L2300/0829 ,  B03C2201/18 ,  G01N35/0098

Abstract: Relates to a microplate carrier (1) for a microplate (2), in whose wells (3) magnetic particles (5), which are suspended in a liquid (4), with or without samples adhering thereto are located, the microplate carrier (1) comprising permanent magnets (6) generating magnetic fields which are implemented to collect and retain the magnetic particles (5) on the floor (14) and/or on the walls (7) of the wells (3) of this microplate (2). The microplate carrier (1) according to the invention is characterized in that it comprises two permanent magnets (6) situated diametrically opposite in relation to the well (3) for each well (3) of the microplate (2), which have the same polarity directed toward the well (3) and whose magnetic axis (25) is at least essentially perpendicular to the footprint of the microplate (2) to be placed. A corresponding method based on the use of the microplate carrier (1) is also disclosed.

Abstract translation: 与微孔板（2）的微板载体（1）相关，微板载体（2）位于其中悬挂在液体（4）中的孔（3）中的磁性颗粒（5））中，附着或不附着样品，微板载体 1）包括产生磁场的永磁体（6），其被实施以收集并保持在该微孔板（2）的孔（3）的地板（14）和/或壁（7）上的磁性颗粒（5） ）。 根据本发明的微孔板载体（1）的特征在于它包括相对于微板（2）的每个孔（3）相对于井（3）径向相对的两个永磁体（6），其具有相同的 指向井（3）的极性，其磁轴（25）至少基本上垂直于要放置的微板（2）的覆盖区。 还公开了基于微板载体（1）的使用的相应方法。

公开(公告)号：US20140036070A1

公开(公告)日：2014-02-06

申请号：US13954158

申请日：2013-07-30

Applicant: Tecan Trading AG

Inventor： Simon M. Eckard ,  Nikolaus Ingenhoven

IPC: G06K9/00

CPC classification number: G06K9/00624 ,  G06T7/74 ,  G06T2207/20104

Abstract: A method of detecting an original arrangement of laboratory articles of a laboratory work station records reference digital images with a digital camera. An image is displayed and visible regions with characteristic features are selected by a user within an input device. Reference image sections and corresponding reference image parameter files are produced and stored. A current arrangement of laboratory articles is compared with a previously recorded original arrangement. Detection of the current arrangement occurred by recording current digital images with a digital camera and creating current image sections defined by X/Y parameters of the reference image parameter files from the current digital images. A computer-based comparison of the processed current image sections with the processed reference image sections occurred and an analysis of this comparison and the display of agreements, deviations and errors is found.

Abstract translation: 检测实验室工作站的实验室物品的原始布置的方法用数字照相机记录参考数字图像。 显示图像，并且用户在输入设备内选择具有特征特征的可见区域。 生成并存储参考图像部分和对应的参考图像参数文件。 将现有的实验室物品安排与以前记录的原始安排进行比较。 通过使用数字照相机记录当前数字图像并且从当前数字图像创建由参考图像参数文件的X / Y参数定义的当前图像部分来发生当前布置的检测。 发生了处理过的当前图像部分与经处理的参考图像部分的基于计算机的比较，并且发现了该比较的分析以及协议，偏差和错误的显示。