公开(公告)号：US09825419B2

公开(公告)日：2017-11-21

申请号：US15245082

申请日：2016-08-23

Applicant: IMRA America, Inc.

Inventor： Takashi Hori ,  Martin E. Fermann

IPC: H01S3/00 ,  H01S3/067 ,  G02F1/39 ,  H01S3/11 ,  H01S3/16 ,  H01S3/30

CPC classification number: H01S3/06758 ,  G02F1/39 ,  G02F2001/392 ,  H01S3/005 ,  H01S3/0057 ,  H01S3/0085 ,  H01S3/0092 ,  H01S3/06708 ,  H01S3/1106 ,  H01S3/1608 ,  H01S3/1611 ,  H01S3/1616 ,  H01S3/1618 ,  H01S3/302 ,  H01S2301/08 ,  H01S2301/085

Abstract: In one aspect, the present disclosure describes a fiber laser system for the generation and delivery of femtosecond (fs) pulses in multiple wavelength ranges. For improved versatility in multi-photon microscopy, an example of a dual wavelength fiber system based on Nd fiber source providing gain at 920 and 1060 nm is described. An example of a three-wavelength system is included providing outputs at 780 nm, 940 nm, and 1050 nm. The systems include dispersion compensation so that high quality fs pulses are provided for applications in microscopy, for example in multiphoton microscope (MPM) systems.

公开(公告)号：US20170326688A1

公开(公告)日：2017-11-16

申请号：US15658944

申请日：2017-07-25

Applicant: IMRA America, Inc.

Inventor： Mark Turner ,  Alan Y. Arai ,  Michiharu Ota

IPC: B23K26/382 ,  B23K26/142 ,  B23K26/402 ,  B23K26/0622 ,  B23K26/146 ,  B23K26/082 ,  B23K26/067 ,  B23K103/00

CPC classification number: B23K26/382 ,  B23K26/0624 ,  B23K26/064 ,  B23K26/0676 ,  B23K26/082 ,  B23K26/122 ,  B23K26/142 ,  B23K26/146 ,  B23K26/402 ,  B23K2103/50 ,  B23K2103/52 ,  B23K2103/54

Abstract: The present disclosure provides examples of a laser-based material processing system for liquid-assisted, ultrashort pulse (USP) laser micromachining An example material processing application includes drilling thru-holes or blind holes in a nearly transparent glass workpiece (substrate) using parallel processing with an n×m array of focused laser beams. Methods and systems are disclosed herein which provide for formation of high aspect ratio holes with low taper in fine pitch arrangements.

公开(公告)号：US20170226560A1

公开(公告)日：2017-08-10

申请号：US15356950

申请日：2016-11-21

Applicant: IMRA America, Inc.

Inventor： Wei Qian ,  Bing Liu ,  Kori Michael Fetters

IPC: C12Q1/37 ,  G01N33/58

CPC classification number: C12Q1/37 ,  G01N33/587 ,  G01N2333/81 ,  G01N2333/948

Abstract: In the present invention, a method and assay for the detection of proteases and protease inhibitors using colloidal gold nanoparticles and peptide substrates, which are selectively recognized and cleaved by proteases being assayed, is disclosed. In this assay, the mechanism of signal generation relies on peptide sequence induced aggregation of gold nanoparticles, which are used as signal reporters. The peptide sequences that induce aggregation are either the intact peptide substrates or proteolytic fragments of the intact peptide substrate wherein the proteolytic fragments are produced by the protease being assayed. The present invention provides a novel, simple, sensitive, and inexpensive colloidal gold nanoparticle-based colorimetric assay that allows both visual and quantitative detection of proteases and protease inhibitors.

公开(公告)号：US09698559B2

公开(公告)日：2017-07-04

申请号：US14964779

申请日：2015-12-10

Applicant: IMRA AMERICA, INC.

Inventor： Martin E. Fermann ,  Ingmar Hartl

IPC: H01S3/10 ,  H01S3/11 ,  G01N21/31 ,  H01S3/23 ,  G01B9/02 ,  G02B6/02 ,  H01S3/067 ,  H01S3/08 ,  H01S3/106 ,  H01S3/13 ,  H01S3/139

CPC classification number: H01S3/10046 ,  G01B9/02001 ,  G01N21/31 ,  G01N2021/317 ,  G02B6/02304 ,  H01S3/0675 ,  H01S3/06754 ,  H01S3/08054 ,  H01S3/1067 ,  H01S3/1068 ,  H01S3/11 ,  H01S3/1115 ,  H01S3/13 ,  H01S3/1307 ,  H01S3/1392 ,  H01S3/1394 ,  H01S3/2383

Abstract: The invention relates to scanning pulsed laser systems for optical imaging. Coherent dual scanning laser systems (CDSL) are disclosed and some applications thereof. Various alternatives for implementation are illustrated, including highly integrated configurations. In at least one embodiment a coherent dual scanning laser system (CDSL) includes two passively modelocked fiber oscillators. The oscillators are configured to operate at slightly different repetition rates, such that a difference δfr in repetition rates is small compared to the values fr1 and fr2 of the repetition rates of the oscillators. The CDSL system also includes a non-linear frequency conversion section optically connected to each oscillator. The section includes a non-linear optical element generating a frequency converted spectral output having a spectral bandwidth and a frequency comb comprising harmonics of the oscillator repetition rates. A CDSL may be arranged in an imaging system for one or more of optical imaging, microscopy, micro-spectroscopy and/or THz imaging.

公开(公告)号：US20170187161A1

公开(公告)日：2017-06-29

申请号：US15460040

申请日：2017-03-15

Applicant: IMRA America, Inc.

Inventor： Martin E. Fermann ,  Naoya Kuse ,  Kevin F. Lee

IPC: H01S3/11 ,  H01S3/10 ,  H01S3/13 ,  H01S3/094 ,  H01S3/131 ,  H01S3/16 ,  H01S3/067 ,  H01S3/23 ,  H01S3/108 ,  H01S3/106 ,  H01S3/0941

CPC classification number: H01S3/1112 ,  H01S3/06758 ,  H01S3/094003 ,  H01S3/0941 ,  H01S3/10061 ,  H01S3/105 ,  H01S3/106 ,  H01S3/1067 ,  H01S3/107 ,  H01S3/108 ,  H01S3/1115 ,  H01S3/1118 ,  H01S3/1305 ,  H01S3/1312 ,  H01S3/139 ,  H01S3/1608 ,  H01S3/2308 ,  H01S2301/02

Abstract: The present disclosure relates to the design of fiber frequency comb lasers with low carrier phase noise. Examples of these low carrier phase noise oscillators can be constructed from both soliton and dispersion compensated fiber lasers via the use of intra-cavity amplitude modulators such as graphene modulators. In low carrier phase noise dispersion compensated fiber frequency comb lasers, graphene and/or bulk modulators can further be used, for example, for phase locking of one comb line to an external continuous wave (cw) reference laser via high bandwidth control of the repetition rate of the comb laser via the graphene modulator. As a result a low phase noise radio frequency (RF) signal can be generated. In some implementations, a frequency comb exhibiting phase noise suppression of at least about 10 dB over a frequency range up to about 100 kHz is provided.

公开(公告)号：US20170179676A1

公开(公告)日：2017-06-22

申请号：US15439062

申请日：2017-02-22

Applicant: IMRA AMERICA, INC.

Inventor： Donald J. HARTER ,  Gyu C. CHO ,  Zhenlin LIU ,  Martin E. FERMANN ,  Xinhua GU ,  Salvatore F. NATI ,  Lawrence SHAH ,  Ingmar HARTL ,  Mark BENDETT

IPC: H01S3/11 ,  H01S3/0941 ,  H01S3/094 ,  H01S3/108 ,  H01S3/23 ,  H01S3/109 ,  H01S3/00 ,  H01S3/13 ,  H01S3/067 ,  H01S3/16

CPC classification number: H01S3/1106 ,  H01S3/005 ,  H01S3/0057 ,  H01S3/0064 ,  H01S3/0085 ,  H01S3/0092 ,  H01S3/06712 ,  H01S3/06725 ,  H01S3/0675 ,  H01S3/06754 ,  H01S3/06758 ,  H01S3/094003 ,  H01S3/094019 ,  H01S3/094042 ,  H01S3/094076 ,  H01S3/09415 ,  H01S3/1086 ,  H01S3/109 ,  H01S3/11 ,  H01S3/1118 ,  H01S3/1305 ,  H01S3/1611 ,  H01S3/1618 ,  H01S3/1643 ,  H01S3/235

Abstract: The invention describes classes of robust fiber laser systems usable as pulse sources for Nd: or Yb: based regenerative amplifiers intended for industrial settings. The invention modifies adapts and incorporates several recent advances in FCPA systems to use as the input source for this new class of regenerative amplifier.

公开(公告)号：US09640940B2

公开(公告)日：2017-05-02

申请号：US14685320

申请日：2015-04-13

Applicant: IMRA America, Inc.

Inventor： Xinhua Gu ,  Mark Bendett ,  Gyu Cheon Cho ,  Martin E. Fermann

IPC: H01S3/098 ,  H01S3/11 ,  H01S3/094 ,  H01S3/16 ,  H01S3/00 ,  H01S3/0941 ,  H01S3/102 ,  H01S3/067 ,  H01S3/13

CPC classification number: H01S3/1115 ,  H01S3/0057 ,  H01S3/0064 ,  H01S3/0078 ,  H01S3/06712 ,  H01S3/06741 ,  H01S3/06754 ,  H01S3/094003 ,  H01S3/094042 ,  H01S3/0941 ,  H01S3/1028 ,  H01S3/1305 ,  H01S3/1618 ,  H01S3/1698

Abstract: A pulsed laser comprises an oscillator and amplifier. An attenuator and/or pre-compressor may be disposed between the oscillator and amplifier to improve performance and possibly the quality of pulses output from the laser. Such pre-compression may be implemented with spectral filters and/or dispersive elements between the oscillator and amplifier. The pulsed laser may have a modular design comprising modular devices that may have Telcordia-graded quality and reliability. Fiber pigtails extending from the device modules can be spliced together to form laser system. In one embodiment, a laser system operating at approximately 1050 nm comprises an oscillator having a spectral bandwidth of approximately 19 nm. This oscillator signal can be manipulated to generate a pulse having a width below approximately 90 fs. A modelocked linear fiber laser cavity with enhanced pulse-width control includes concatenated sections of both polarization-maintaining and non-polarization-maintaining fibers. Apodized fiber Bragg gratings and integrated fiber polarizers are included in the cavity to assist in linearly polarizing the output of the cavity. Very short pulses with a large optical bandwidth are obtained by matching the dispersion value of the fiber Bragg grating to the inverse of the dispersion of the intra-cavity fiber.

公开(公告)号：US09632243B2

公开(公告)日：2017-04-25

申请号：US14644779

申请日：2015-03-11

Applicant: IMRA America, Inc.

Inventor： Liang Dong ,  Jun Li ,  Hugh McKay ,  Libin Fu ,  Andrius Marcinkevicius

IPC: G02B6/028 ,  H01S3/067 ,  G02B6/02 ,  H01S3/091 ,  H01S3/11 ,  G02B6/14

CPC classification number: G02B6/0288 ,  G02B6/02009 ,  G02B6/02333 ,  G02B6/02357 ,  G02B6/02361 ,  G02B6/02366 ,  G02B6/02371 ,  G02B6/0283 ,  G02B6/14 ,  H01S3/06729 ,  H01S3/06754 ,  H01S3/091 ,  H01S3/11

Abstract: Embodiments of optical fiber may include cladding features that include a material (e.g., fluorine-doped silica glass) that may produce a very low relative refractive index difference with respect to cladding material in which the cladding features are disposed. This relative refractive index difference may be characterized by (n1-n2)/n1, where n1 is the index of refraction of the cladding material in which the cladding features are included, and n2 is the index of refraction of the cladding features. In certain embodiments, the relative refractive index difference may be less than about 4.5×10−3. In various embodiments, the configuration of the cladding features including, for example, the size and spacing of the cladding features, can be selected to provide for confinement of the fundamental mode yet leakage for the second mode and higher modes, which may provide mode filtering, single mode propagation, and/or low bend loss.

公开(公告)号：US20160365697A1

公开(公告)日：2016-12-15

申请号：US15245082

申请日：2016-08-23

Applicant: IMRA America, Inc.

Inventor： Takashi Hori ,  Martin E. Fermann

IPC: H01S3/067 ,  G02F1/39 ,  H01S3/16 ,  H01S3/00 ,  H01S3/11 ,  H01S3/30

CPC classification number: H01S3/06758 ,  G02F1/39 ,  G02F2001/392 ,  H01S3/005 ,  H01S3/0057 ,  H01S3/0085 ,  H01S3/0092 ,  H01S3/06708 ,  H01S3/1106 ,  H01S3/1608 ,  H01S3/1611 ,  H01S3/1616 ,  H01S3/1618 ,  H01S3/302 ,  H01S2301/08 ,  H01S2301/085

Abstract: In one aspect, the present disclosure describes a fiber laser system for the generation and delivery of femtosecond (fs) pulses in multiple wavelength ranges. For improved versatility in multi-photon microscopy, an example of a dual wavelength fiber system based on Nd fiber source providing gain at 920 and 1060 nm is described. An example of a three-wavelength system is included providing outputs at 780 nm, 940 nm, and 1050 nm. The systems include dispersion compensation so that high quality fs pulses are provided for applications in microscopy, for example in multiphoton microscope (MPM) systems.

Abstract translation: 一方面，本公开描述了用于在多个波长范围内生成和传送飞秒（fs）脉冲的光纤激光系统。 为了改善多光子显微镜的多功能性，描述了基于提供920和1060nm的增益的Nd光纤源的双波长光纤系统的示例。 包括三波长系统的实例包括提供780nm，940nm和1050nm的输出。 这些系统包括色散补偿，以便提供高质量的fs脉冲用于显微镜应用，例如在多光子显微镜（MPM）系统中。

公开(公告)号：US09407056B2

公开(公告)日：2016-08-02

申请号：US14617028

申请日：2015-02-09

Applicant: IMRA AMERICA, INC.

Inventor： Jingzhou Xu ,  Gyu Cho

IPC: H01S3/10 ,  H01S3/067 ,  H01S3/00 ,  G02F1/35 ,  G02B5/30

CPC classification number: H01S3/06712 ,  G02B5/3083 ,  G02F1/353 ,  G02F1/3544 ,  G02F2001/3546 ,  H01S3/0092 ,  H01S3/067 ,  H01S3/06754 ,  H01S3/10053 ,  H01S3/10061

Abstract: In at least one embodiment a laser system includes a fiber laser source, a polarization controller and a wavelength converter. The relative power distribution between a pump wavelength and a signal wavelength is controllable using the polarization controller. An optional phase compensator is used to control polarization state of the output laser beam. In various embodiments the relative power distribution among multiple wavelengths may be controlled over a range of at least about 100:1.