公开(公告)号：US20140158882A1

公开(公告)日：2014-06-12

申请号：US14180915

申请日：2014-02-14

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

IPC: H01J49/04

CPC classification number: H01J49/0404 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/4215

Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

Abstract translation: 本发明一般涉及用于转移离子进行分析的系统和方法。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括用于将样品分子转化成大气压的区域中的气相离子的电离源，离子分析装置和可操作地耦合到气体的离子传递构件 气体发生装置，其中气体流动产生装置产生将气相离子通过离子传递构件转移到离子分析装置的入口的层流气流。

公开(公告)号：US20140051180A1

公开(公告)日：2014-02-20

申请号：US14052815

申请日：2013-10-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: G01N27/62

CPC classification number: H01J49/045 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/0445 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

Abstract translation: 本发明一般涉及用于使离子产生与不连续大气界面的循环同步的方法和装置。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括产生样品离子的质谱探针，不连续大气界面和质量分析仪，其中该系统配置成使得离子形成与 不连续大气界面。

公开(公告)号：US20250062113A1

公开(公告)日：2025-02-20

申请号：US18937451

申请日：2024-11-05

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Amar S. Basu ,  Wen-Ping Peng

IPC: H01J49/42 ,  G01N27/623 ,  H01J49/00 ,  H01J49/16

Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

公开(公告)号：US20250029827A1

公开(公告)日：2025-01-23

申请号：US18907844

申请日：2024-10-07

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks

IPC: H01J49/16 ,  H01J49/00

Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.

公开(公告)号：US12157725B2

公开(公告)日：2024-12-03

申请号：US17893399

申请日：2022-08-23

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Christopher Pulliam ,  Ryan M. Bain

IPC: C07D213/04 ,  C07C45/72 ,  C07D209/40 ,  C07J41/00

Abstract: The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.

公开(公告)号：US12154779B2

公开(公告)日：2024-11-26

申请号：US18108222

申请日：2023-02-10

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Amar S. Basu ,  Wen-Ping Peng

IPC: H01J49/00 ,  G01N27/623 ,  H01J49/16 ,  H01J49/42

Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

公开(公告)号：US12027355B2

公开(公告)日：2024-07-02

申请号：US18142212

申请日：2023-05-02

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/00

CPC classification number: H01J49/0027 ,  H01J49/004 ,  H01J49/0081 ,  H01J49/0013

Abstract: The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.

公开(公告)号：US20240063009A1

公开(公告)日：2024-02-22

申请号：US18385656

申请日：2023-10-31

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Lucas Szalwinski

IPC: H01J49/00

CPC classification number: H01J49/004 ,  H01J49/0031 ,  H01J49/0081

Abstract: The invention generally relates to two-dimensional mass spectrometry using ion micropacket detection. In certain aspects, the invention provides systems including a mass spectrometer having an ion trap and one or more detectors. The system includes a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to: apply one or more scan functions to the ion trap that excite a precursor ion and eject a product ion from the ion trap; and determine a secular frequency of the product ion by detecting micropackets of the product ion as the micropackets are ejected from the ion trap.

公开(公告)号：US11903707B2

公开(公告)日：2024-02-20

申请号：US17692613

申请日：2022-03-11

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  A61B5/157 ,  G01N1/02

CPC classification number: A61B5/1477 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  G01N33/4833 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34 ,  A61B5/145 ,  A61B5/1405 ,  A61B5/157 ,  A61B5/150015 ,  A61B5/150992 ,  A61M2202/0468 ,  G01N2001/028

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20240038523A1

公开(公告)日：2024-02-01

申请号：US18378247

申请日：2023-10-10

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks

IPC: H01J49/16 ,  H01J49/00

CPC classification number: H01J49/165 ,  H01J49/0013

Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.