公开(公告)号：US20240377425A1

公开(公告)日：2024-11-14

申请号：US18782221

申请日：2024-07-24

Applicant: Cytiva Sweden AB

Inventor： Johan BLOMBERG ,  Mats LUNDKVIST

IPC: G01N35/10 ,  B01D15/08 ,  B01D15/10 ,  B01D17/12 ,  B01D29/60 ,  G01N30/02 ,  G01N30/24 ,  G01N30/38 ,  G01N30/88 ,  G01N35/00

Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

公开(公告)号：US12117389B2

公开(公告)日：2024-10-15

申请号：US17487722

申请日：2021-09-28

Applicant: Cytiva Sweden AB

Inventor： Henrik Svanberg ,  Hanno Ehring ,  Erik Nils Ostlund

IPC: G01N21/05 ,  G02B6/36 ,  G02B6/38 ,  G02B6/42

CPC classification number: G01N21/05 ,  G02B6/3616 ,  G02B6/3644 ,  G02B6/3825 ,  G02B6/3861 ,  G02B6/4219 ,  G01N2021/052 ,  G01N2201/0664 ,  G01N2201/0668 ,  G01N2201/0813 ,  G01N2201/086 ,  G02B6/36

Abstract: The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell.

公开(公告)号：US20240221875A1

公开(公告)日：2024-07-04

申请号：US18557550

申请日：2022-04-29

Applicant: CYTIVA SWEDEN AB

Inventor： Peter Andersson ,  Alexander Kele ,  Todd Ward ,  David Henderson ,  Vanessa Hoskins ,  Dean Whitney ,  Robin Modigh ,  Per LIDÉN ,  Olga Szaduro ,  Daniel Mynarski ,  Adam Sipos ,  Peter Cserna ,  David Birkas ,  Istvan Toth ,  Júlia Tünde GÁL ,  Hajnalka Albert ,  Zsofia Vasne Utassy ,  Edina Szava ,  Tim Bervoets

IPC: G16H10/40 ,  G16H15/00

CPC classification number: G16H10/40 ,  G16H15/00

Abstract: Methods and apparatus for cloud-based data management and reporting for bioprocess development. The system for process data management disclosed herein includes memory and processor circuitry to execute machine readable instructions to at least retrieve a first data set from at least one of an electronic laboratory notebook or a first laboratory device, retrieve a second data set from a second laboratory device, link the first data set and the second data set to a project, the first data and the second data set linked to the project based on a type of data in the first data set and the second data set, generate a data overlay using the first data set and the second data set, the data overlay including an overlay of a first chromatogram and a second chromatogram and generate a report including the data overlay.

公开(公告)号：US12017215B2

公开(公告)日：2024-06-25

申请号：US16486736

申请日：2018-02-27

Applicant: Cytiva Sweden AB

Inventor： Tuomo Valtteri Frigard ,  Robert Magnusson ,  Mats Lundkvist ,  Karl Axel Jakob Liderfelt ,  Helena Nordvarg ,  Andreas Torbjorn Lundin ,  Peter Arne Reffner

IPC: B01L3/00 ,  B01D15/10 ,  B01D61/14

CPC classification number: B01L3/502715 ,  B01D15/10 ,  B01D61/145 ,  B01L3/502738 ,  B01L3/502761 ,  B01D2311/2626 ,  B01D2315/16 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2300/0627 ,  B01L2300/0809 ,  B01L2300/0864 ,  B01L2400/06

Abstract: Disclosed is a modular bio-processing unit (100) comprising: a housing (110) having one or more internal fluid paths (101), the housing having at least one inlet and at least one outlet (5,10,15,20,25,30,35,40,45,50,55,60,65,70), each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements (120,150,170,190) operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components (140) operatively associated with the or each fluid path; and plural valves (180) for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing.

公开(公告)号：US20240182834A1

公开(公告)日：2024-06-06

申请号：US18553821

申请日：2022-04-25

Applicant: CYTIVA SWEDEN AB

Inventor： Andreas Lundin ,  Mats Rimmo

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00

CPC classification number: C12M29/04 ,  C12M23/40 ,  C12M23/42 ,  C12M23/44 ,  C12M41/30 ,  C12M41/48

Abstract: The present disclosure relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations within the bioprocessing system (80), the bioprocessing system (80) comprising: a base unit (60) comprising a plurality of valve actuators, wherein at least one of the plurality of valve actuators is configured to releasably engage with a membrane valve cassette (200, 300, 400) that is removably attachable to the base unit (60), and wherein the at least one of the plurality of valve actuators is actuatable to regulate fluid flow through the membrane valve cassette (200, 300, 400); and a control system (20) operable to selectively actuate respective ones of the plurality of valve actuators to provide a valve configuration within the membrane valve cassette (200, 300, 400) to enable the base unit (60) and the membrane valve cassette (200, 300, 400) together to perform one of the predetermined set of bioprocessing operations.

公开(公告)号：US11961295B2

公开(公告)日：2024-04-16

申请号：US17822068

申请日：2022-08-24

Applicant: Cytiva Sweden AB

Inventor： Petra Bangtsson ,  Johan Arthursson ,  Key Hyckenberg ,  Lotta Hedkvist

IPC: G06K9/00 ,  G06T7/00 ,  G06T11/00 ,  G06V20/20

CPC classification number: G06V20/20 ,  G06T7/001 ,  G06T11/00 ,  G06T2207/30164

Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.

公开(公告)号：US20240043879A1

公开(公告)日：2024-02-08

申请号：US18467658

申请日：2023-09-14

Applicant: Cytiva Sweden AB

Inventor： Daniel Ivansson ,  Andreas Castan

IPC: C12N15/90 ,  C12P21/00 ,  C07K16/00

CPC classification number: C12N15/907 ,  C12P21/00 ,  C07K16/00 ,  C12N2510/02

Abstract: The present invention relates to an improved method for cell line development (CLD) which is generally applicable to production of any therapeutic protein that can be produced using mammalian Cell lines and in particular Chinese Hamster Ovary (CHO) cells.
The method combines site-directed integration (SDI), expression construct components improving the post-transcriptional processing of the gene of interest (GOI) and the introduction of a onetime pre-CLD host cell line selection workflow to generate a production competent cell line that can then be used in multiple CLD efforts using SDI from that point on.

公开(公告)号：US11867330B2

公开(公告)日：2024-01-09

申请号：US17056510

申请日：2019-05-29

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: A61M39/16 ,  F16L35/00

CPC classification number: F16L35/00 ,  A61M39/165 ,  F16L2201/10 ,  F16L2201/44 ,  F16L2201/60 ,  F16L2201/80

Abstract: A connector for forming a substantially aseptic connection is provided, said connector having a connector member a coupling end with a coupling element for engaging a similar coupling element on a similar connector to form a seal. A method for connecting and disconnecting two such connectors is also provided.

公开(公告)号：US11820084B2

公开(公告)日：2023-11-21

申请号：US17413702

申请日：2019-12-18

Applicant: Cytiva Sweden AB

Inventor： Hanish Lakhani ,  Preetam Hosamani ,  Nishu Garg ,  Bhaskaran Savarimuthu ,  Srihari Kannuri ,  Juzar Mazhar Ezzy ,  Ramu Balaguru

IPC: B29C65/00 ,  B29C65/04 ,  B29C65/14 ,  B29C65/16 ,  B29C65/82

CPC classification number: B29C66/965 ,  B29C65/04 ,  B29C65/1425 ,  B29C65/16 ,  B29C65/8253 ,  B29C66/4312 ,  B29C66/73921 ,  B29C66/8322 ,  B29C66/857 ,  B29C66/861 ,  B29C66/91231 ,  B29C66/9221 ,  B29C66/9231 ,  B29C66/932 ,  B29C66/963 ,  B29C66/9672 ,  B29C66/9674 ,  B29C66/974

Abstract: Disclosed is an automated method (54) which includes directing rays from a source (34) to a tube (38) disposed between relatively movable first and second sealing plates (20, 32), capturing an image (70) of at least a portion of the tube (38) by an image capturing device (26), and transferring the captured image (70) to a processing device (24). The method (54) also includes determining a plurality of tube parameters by the processing device (24) based on the captured image (70), using an image processing technique and determining a plurality of sealing parameters from a database (44) by the processing device (24) based on the determined plurality of tube parameters. Additionally, the method (54) includes controlling the drive unit (22) and a heater (36) by the processing device (24) influenced by the determined plurality of sealing parameters, to respectively compress the tube (36) and perform heat sealing of the tube (38).

公开(公告)号：US20230364534A1

公开(公告)日：2023-11-16

申请号：US18248041

申请日：2021-10-07

Applicant: CYTIVA SWEDEN AB

Inventor： Johan Alriksson ,  Rodrigo Hernandez Vera ,  Ori Levin ,  Ida Lindell

IPC: B01D29/88 ,  B01D29/00 ,  B01D29/085 ,  B33Y10/00

CPC classification number: B01D29/885 ,  B01D29/0093 ,  B01D29/085 ,  B33Y10/00 ,  B01D2201/02

Abstract: Filter caps 200, 400, 500, 600, 700 are provided that include internal geometry that modulate flow characteristics above the surface of a membrane filter held within the filter cap 200, 400, 500, 600, 700. The internal geometry in some cases provide for recirculation within the filter cap 200, 400, 500, 600, 700 that provides a cross flow element across the filter membrane that reduces clogging of the filter.