-
公开(公告)号:US20140199468A1
公开(公告)日:2014-07-17
申请号:US14201965
申请日:2014-03-10
发明人: Jie Wen , Patrick E. Guire
CPC分类号: D01D5/003 , A61L27/50 , A61L29/14 , A61L31/14 , A61L2400/12 , B05D3/067 , B29C35/08 , C12M23/20 , D01D5/0007 , D01F1/10 , D01F6/625 , D06M15/263 , D06M15/273 , D06M15/285 , D06M2400/01
摘要: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.
摘要翻译: 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面,以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的,并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。
-
公开(公告)号:US08709809B2
公开(公告)日:2014-04-29
申请号:US12666173
申请日:2008-06-20
申请人: Jie Wen , Patrick E. Guire
发明人: Jie Wen , Patrick E. Guire
CPC分类号: D01D5/003 , A61L27/50 , A61L29/14 , A61L31/14 , A61L2400/12 , B05D3/067 , B29C35/08 , C12M23/20 , D01D5/0007 , D01F1/10 , D01F6/625 , D06M15/263 , D06M15/273 , D06M15/285 , D06M2400/01
摘要: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.
摘要翻译: 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面,以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的,并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。
-
公开(公告)号:US08496857B2
公开(公告)日:2013-07-30
申请号:US13167104
申请日:2011-06-23
申请人: Patrick E. Guire , Kristin Taton , Jie Wen , Laurie R. Lawin
发明人: Patrick E. Guire , Kristin Taton , Jie Wen , Laurie R. Lawin
IPC分类号: C08K5/06 , C08K5/07 , C08K5/34 , C08L101/02 , C08L101/06 , C07C43/02 , C07C49/00
CPC分类号: C09D7/1233 , C08K5/0025 , C09D7/63 , Y10T428/31507 , Y10T428/31511 , Y10T428/31551 , Y10T428/31678 , Y10T428/31721 , Y10T428/31725 , Y10T428/31855 , Y10T428/31989 , Y10T428/31993
摘要: The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.
摘要翻译: 本发明描述了包含交联化合物,聚合物和任选具有氧化物层的1nm至约25微米尺寸的颗粒的新型组合物。 特别地,颗粒是二氧化硅和已经用硅烷预处理的颗粒。
-
公开(公告)号:US11781035B2
公开(公告)日:2023-10-10
申请号:US16771285
申请日:2018-12-11
发明人: Kristin Taton , Daniel Guire , Nathaniel Olson , Eric Guire , Patrick Guire
IPC分类号: C08G18/32 , C09D175/02 , A61B5/00 , B05D1/02 , B05D1/18 , C08G18/50 , C08G18/66 , C08G18/73 , C08G18/75 , C09D5/16
CPC分类号: C09D175/02 , A61B5/6846 , B05D1/02 , B05D1/18 , C08G18/325 , C08G18/3228 , C08G18/5024 , C08G18/6685 , C08G18/73 , C08G18/755 , C09D5/1662
摘要: Durable polyurea copolymer coatings can be applied to surfaces that come in contact with fluids, such as biological fluids, thereby passivating the surface. Polyurea copolymer coating compositions comprise a reaction product of (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; and (b) a diisocyanate. Solutions containing polyurea copolymers, coated surfaces and methods are also described.
-
公开(公告)号:US10072241B2
公开(公告)日:2018-09-11
申请号:US14774996
申请日:2014-03-12
发明人: Laurie Lawin , Briana Vogen , Daniel Guire , Tahmina Naqvi , Leandro Forciniti
CPC分类号: C12N5/0062 , C12M21/08 , C12M23/02 , C12M23/12 , C12M23/22 , C12M23/58 , C12M25/04 , C12M25/06 , C12M41/46 , C12N2533/30
摘要: Inventive concepts relate generally to the field of cell culture, and more particularly to formation of three-dimensional aggregate(s) of eukaryotic cells. Cell culture vessels including a conical device having an inner surface being hydrophobic; and a frustum defining an open viewing aperture and a narrow end of the conical device are described. Ceil culture vessel arrays, assemblies and kits are described, as well as methods of making and using the devices.
-
公开(公告)号:US09833543B2
公开(公告)日:2017-12-05
申请号:US14351145
申请日:2012-10-11
申请人: Jie Wen , Nell Herrera Wirth , Patrick E Guire
发明人: Jie Wen , Nell Herrera Wirth , Patrick E Guire
IPC分类号: A61L27/56 , A61L27/18 , A61K9/00 , A61L27/22 , A61L27/38 , A61L27/54 , A61L27/58 , A61K38/00
CPC分类号: A61L27/18 , A61K9/0024 , A61K38/00 , A61L27/22 , A61L27/3847 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/12 , A61L2430/02
摘要: Inventive concepts relate general to the field of implantable three-dimensional scaffolds. More particularly, methods of preparing and using implantable nanofibrous tissue scaffolds are described. Inventive scaffolds can be used for treatment of defects in a living organism, such as hard or soft tissue defects including bone.
-
公开(公告)号:US08936907B2
公开(公告)日:2015-01-20
申请号:US13984066
申请日:2012-02-07
申请人: Eric Guire , Jie Wen
发明人: Eric Guire , Jie Wen
IPC分类号: C12Q1/68 , A61K47/32 , C12N15/87 , A61K31/7088 , A61K48/00
CPC分类号: A61K47/32 , A61K31/7088 , A61K48/0075 , C12N15/87 , C12N2810/65
摘要: The invention is directed to transfection reagents for the delivery of nucleic acids into neural cells, compositions including the reagents, methods of preparation of such reagents, methods of transfecting cells with such reagents, and uses thereof. In preferred embodiments the reagents comprise horseradish peroxidase and/or a polycarboxylic acid such as poly(acrylic acid) or poly(methacrylic acid).
摘要翻译: 本发明涉及用于将核酸递送到神经细胞的转染试剂,包括试剂的组合物,这种试剂的制备方法,用这种试剂转染细胞的方法及其用途。 在优选的实施方案中,试剂包含辣根过氧化物酶和/或多元羧酸,例如聚(丙烯酸)或聚(甲基丙烯酸)。
-
公开(公告)号:US11672884B2
公开(公告)日:2023-06-13
申请号:US16771380
申请日:2018-12-11
发明人: Kristin Taton , Patrick Guire , Charles Leir
IPC分类号: A61L31/10 , A61L27/34 , C08G18/61 , C08G18/64 , C08G18/73 , C08G18/75 , C08G18/77 , C09D183/10
CPC分类号: A61L27/34 , A61L31/10 , C08G18/61 , C08G18/6423 , C08G18/73 , C08G18/757 , C08G18/778 , C09D183/10 , C08G2150/00
摘要: Silicone polyurea block copolymers are prepared by copolymerizing: (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; (b) a monofunctional silicone isocyanate; and (c) a diisocyanate. Compositions useful as passivating coatings comprising the block copolymer are also provided, and substrates coated with the compositions. Methods of preparing and using the compositions are also described.
-
公开(公告)号:US09814805B2
公开(公告)日:2017-11-14
申请号:US14786842
申请日:2014-04-25
发明人: Kristin Taton , Lawin Laurie , Patrick Guire
IPC分类号: A61L29/08 , A61L27/54 , A61L31/16 , A61L31/10 , A61L27/34 , A61L29/16 , A61L29/10 , A61L29/06
CPC分类号: A61L29/085 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/106 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/206 , A61L2300/602 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L83/04
摘要: The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.
-
公开(公告)号:US09539371B2
公开(公告)日:2017-01-10
申请号:US14749815
申请日:2015-06-25
发明人: Jie Wen , Kristin Taton , Laurie Lawin , William Knopke , Eric Guire , Patrick Guire
IPC分类号: C09D137/00 , A61L31/10 , C08F8/30 , C08F8/42 , C09D131/00 , A61L31/02 , A61L31/06 , A61L31/14 , A61L31/16 , A61L33/00 , B05D3/06
CPC分类号: C08F8/42 , A61L29/06 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/022 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/0005 , A61L2300/404 , A61L2300/42 , A61L2400/10 , A61L2420/02 , A61L2420/08 , B05D3/06 , C08F8/28 , C08F8/30 , C08F267/04 , C09D131/00 , C09D135/00 , Y10T428/31507 , Y10T428/31511 , Y10T428/31573 , Y10T428/31598 , Y10T428/31663 , Y10T428/31667 , Y10T428/31721 , Y10T428/3175 , Y10T428/31797 , Y10T428/31855 , Y10T428/31884 , Y10T428/31909 , Y10T428/31913 , Y10T428/31928 , C08F222/06
摘要: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied.
摘要翻译: 本发明描述了新颖的涂层剂,其包括聚合物,一个或多个潜在反应性基团和一个或多个非共价连接基团,所选择的非共价连接基团与施加涂覆剂的基底相互作用。
-
-
-
-
-
-
-
-
-