NANOFIBERS CONTAINING LATENT REACTIVE GROUPS
    11.
    发明申请
    NANOFIBERS CONTAINING LATENT REACTIVE GROUPS 审中-公开
    含有反应性组合的纳米纤维素

    公开(公告)号:US20140199468A1

    公开(公告)日:2014-07-17

    申请号:US14201965

    申请日:2014-03-10

    IPC分类号: D01D5/00 B05D3/06 B29C35/08

    摘要: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.

    摘要翻译: 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面,以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的,并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。

    Nanofibers containing latent reactive groups
    12.
    发明授权
    Nanofibers containing latent reactive groups 有权
    含有潜在反应性基团的纳米纤维

    公开(公告)号:US08709809B2

    公开(公告)日:2014-04-29

    申请号:US12666173

    申请日:2008-06-20

    IPC分类号: C12M1/00 A61L27/34

    摘要: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.

    摘要翻译: 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面,以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的,并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。

    Neural transfection reagents
    17.
    发明授权
    Neural transfection reagents 有权
    神经转染试剂

    公开(公告)号:US08936907B2

    公开(公告)日:2015-01-20

    申请号:US13984066

    申请日:2012-02-07

    申请人: Eric Guire Jie Wen

    发明人: Eric Guire Jie Wen

    摘要: The invention is directed to transfection reagents for the delivery of nucleic acids into neural cells, compositions including the reagents, methods of preparation of such reagents, methods of transfecting cells with such reagents, and uses thereof. In preferred embodiments the reagents comprise horseradish peroxidase and/or a polycarboxylic acid such as poly(acrylic acid) or poly(methacrylic acid).

    摘要翻译: 本发明涉及用于将核酸递送到神经细胞的转染试剂,包括试剂的组合物,这种试剂的制备方法,用这种试剂转染细胞的方法及其用途。 在优选的实施方案中,试剂包含辣根过氧化物酶和/或多元羧酸,例如聚(丙烯酸)或聚(甲基丙烯酸)。