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公开(公告)号：US20200086032A1
公开(公告)日：2020-03-19
申请号：US16614838
申请日：2018-05-21
Applicant: CYTOSORBENTS CORPORATION
Inventor： Phillip CHAN
Abstract: The present invention concerns methods of treating a patient suffering from a traumatic brain injury (TBI), comprising contacting said patient's blood with a sorbent for an inflammatory mediator and kits for performing such treatments.
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公开(公告)号：US20180311273A1
公开(公告)日：2018-11-01
申请号：US16018603
申请日：2018-06-26
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K31/74 , B01J20/28 , A61K9/16 , B01J20/26 , B01J20/30 , A61K9/50 , C08F212/36 , C08J9/26 , A61K9/00 , A61K31/75
CPC classification number: A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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公开(公告)号：US12121879B2
公开(公告)日：2024-10-22
申请号：US17298968
申请日：2019-12-02
Applicant: CytoSorbents Corporation
Inventor： Tamaz Guliashvili , Maryann Gruda , Thomas Golobish , David James , Karl-Gustav Ruggeberg , Pamela O'Sullivan , Sarah Patterson
CPC classification number: B01J20/3274 , B01D15/3809 , B01J20/28019 , B01J20/28078 , B01J20/3212 , C07K1/22 , C07K16/065
Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.
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公开(公告)号：US11969535B2
公开(公告)日：2024-04-30
申请号：US16645965
申请日：2018-09-13
Applicant: CYTOSORBENTS CORPORATION
Inventor： Dominik Gutzler , Wei-Tai Young
CPC classification number: A61M1/3666 , A61M1/1698 , A61M1/3679 , A61M39/24 , A61M39/28 , A61M1/3623 , A61M2202/0415
Abstract: Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, a second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.
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15.发明公开公开(公告)号：US20240082817A1
公开(公告)日：2024-03-14
申请号：US18502809
申请日：2023-11-06
Applicant: CytoSorbents Corporation
Inventor： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
CPC classification number: B01J20/261 , A61K9/0031 , A61K9/0053 , A61K31/745 , A61M1/3679 , B01D15/34 , B01J20/262 , B01J20/267 , B01J20/28069 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28085 , B01J20/3208 , B01J20/3231 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01D15/125
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
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Patent Agency Ranking
公开(公告)号：US20220032271A1
公开(公告)日：2022-02-03
申请号：US17298968
申请日：2019-12-02
Applicant: CytoSorbents Corporation
Inventor： Tamaz GULIASHVILI , Maryann GRUDA , Thomas GOLOBISH , David JAMES , Karl-Gustav RUGGEBERG , Pamela O'SULLIVAN , Sarah PATTERSON
Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.
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17.发明申请公开(公告)号：US20220032267A1
公开(公告)日：2022-02-03
申请号：US17372985
申请日：2021-07-12
Applicant: CytoSorbents Corporation
Inventor： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：US20210402075A1
公开(公告)日：2021-12-30
申请号：US17313424
申请日：2021-05-06
Applicant: CytoSorbents Corporation
Inventor： Thomas D. Golobish , Vincent J. Capponi , David R. Clay
Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
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公开(公告)号：US11058715B2
公开(公告)日：2021-07-13
申请号：US15172209
申请日：2016-06-03
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K31/74 , A61K31/75 , A61K9/00 , A61K9/16 , A61K9/50 , B01J20/26 , B01J20/28 , B01J20/30 , C08F212/36 , C08J9/26 , A61K47/58
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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公开(公告)号：US11020521B2
公开(公告)日：2021-06-01
申请号：US16851305
申请日：2020-04-17
Applicant: CytoSorbents Corporation
Inventor： Thomas D. Golobish , Vincent J. Capponi , David R. Clay
Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
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