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公开(公告)号：US09546165B2
公开(公告)日：2017-01-17
申请号：US13499835
申请日：2010-10-05
Applicant: Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
Inventor： Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
IPC: C07D471/04 , C07D487/04 , C07D239/94 , C07D241/26 , C07D213/82 , C07D213/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D491/052 , C07D519/00 , C07D241/28 , C07D498/04
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
Abstract translation: 本发明提供了可用作PDK1抑制剂的化合物。 本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。
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公开(公告)号：US08778977B2
公开(公告)日：2014-07-15
申请号：US12307104
申请日：2007-07-02
Applicant: Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
Inventor： Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
IPC: A61K31/5377 , A61K31/506 , A61K31/519 , A61K31/4985 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/443 , A61K31/4412 , C07D487/04 , C07D471/04 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D409/14 , C07D409/12 , C07D405/14 , C07D405/12 , C07D401/14 , C07D401/12 , C07D211/86
CPC classification number: C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
Abstract: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
Abstract translation: 本发明提供吡啶基PDK1抑制剂和使用其制备癌症的方法。
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13.发明授权Indazole derivatives as modulators of interleukin-1 receptor-associated kinase 有权吲唑衍生物作为白细胞介素-1受体相关激酶的调节剂公开(公告)号：US08293923B2
公开(公告)日：2012-10-23
申请号：US12440163
申请日：2007-09-07
Applicant: Kevin Guckian , Charles Jewell , Patrick Conlon , Edward Yin Shiang Lin , Timothy Chan
Inventor： Kevin Guckian , Charles Jewell , Patrick Conlon , Edward Yin Shiang Lin , Timothy Chan
IPC: A61K31/4188 , A61K31/5355 , C07D401/14 , C07D403/12
CPC classification number: C07D403/12 , C07D401/14 , C07D403/14
Abstract: The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases.
Abstract translation: 本发明涉及式（I）的IRAK激酶的调节剂，并提供包含这种调节剂的组合物，以及其用于治疗IRAK介导的或与IRAK相关的病症或疾病的方法。
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公开(公告)号：US20100240617A1
公开(公告)日：2010-09-23
申请号：US12705969
申请日：2010-02-15
Applicant: Kevin R. Lynch , Timothy L. MacDonald , Kevin Guckian , Edward Yin-shiang Lin , Bin Ma
Inventor： Kevin R. Lynch , Timothy L. MacDonald , Kevin Guckian , Edward Yin-shiang Lin , Bin Ma
IPC: A61K31/661 , C07C317/10 , C07C49/215 , C07C229/34 , C07C211/38 , C07F9/09 , C07D271/06 , C07D271/10 , C07D333/02 , A61K31/122 , A61K31/235 , A61K31/135 , A61K31/4245 , A61K31/381 , A61P37/02
CPC classification number: C07C323/32 , C07C215/38 , C07C217/74 , C07D271/06 , C07D333/16 , C07D413/04 , C07F9/091
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US09340527B2
公开(公告)日：2016-05-17
申请号：US13983489
申请日：2012-02-03
Applicant: Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Kevin Guckian , Gnanasambandam Kumaravel
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC: C07D401/06 , C07D215/20 , C07D211/34 , C07D211/62 , C07D211/60 , C07D405/12
CPC classification number: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
Abstract: Compounds of formula (I) or (II) can modulate the activity of SIP receptors.
Abstract translation: 式（I）或（II）的化合物可以调节SIP受体的活性。
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Patent Agency Ranking
公开(公告)号：US20120190649A1
公开(公告)日：2012-07-26
申请号：US13389054
申请日：2010-08-05
Applicant: Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/683 , C07C47/575 , C07C311/51 , C07C229/36 , C07D205/04 , C07D207/16 , C07D211/62 , C07D215/227 , C07D239/74 , C07D403/06 , A61K31/085 , A61K31/11 , A61K31/21 , A61K31/216 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/47 , A61K31/517 , A61K31/662 , A61P25/00 , A61P37/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P1/00 , A61P3/10 , A61K31/56 , A61P11/08 , A61P37/06 , A61P37/02 , C07C43/247
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US20100160258A1
公开(公告)日：2010-06-24
申请号：US12588883
申请日：2009-10-30
Applicant: Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: A61K31/66 , C12Q1/48 , A61K31/135 , C07F9/06 , C07C223/02
CPC classification number: A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US20140100195A1
公开(公告)日：2014-04-10
申请号：US13646143
申请日：2012-10-05
Applicant: Richard D. Caldwell , Kevin M. GUCKIAN , Gnanasambandam KUMARA VEL , Wen-Cherng LEE , Edward Yin-Shiang LIN , Xiaogao LlU , Bin MA , Daniel M. SCOTT , Zhan SHl , Jermaine THOMAS , Arthur G. TAVERAS , Guo Zhu ZHENG
Inventor： Richard D. Caldwell , Kevin M. GUCKIAN , Gnanasambandam KUMARA VEL , Wen-Cherng LEE , Edward Yin-Shiang LIN , Xiaogao LlU , Bin MA , Daniel M. SCOTT , Zhan SHl , Jermaine THOMAS , Arthur G. TAVERAS , Guo Zhu ZHENG
IPC: A61K31/685 , A61K31/195 , C07C229/36 , A61K31/216 , C07C217/58 , A61K31/137 , C07D263/24 , A61K31/421 , C07D215/20 , A61K31/47 , C07F9/60 , A61K31/675 , C07D239/80 , A61K31/517 , C07D413/04 , C07F9/6512 , C07D277/64 , A61K31/428 , A61P37/06 , A61P7/00 , C07C233/47
CPC classification number: C07F9/6512 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/20 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F9/091 , C07F9/60 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US20120208819A1
公开(公告)日：2012-08-16
申请号：US13499835
申请日：2010-10-05
Applicant: Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
Inventor： Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
IPC: A61K31/53 , C07D401/14 , C07D409/14 , A61P35/00 , A61K31/444 , A61K31/519 , A61K31/4439 , A61K31/517 , C07D471/04 , C07D401/12
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
Abstract translation: 本发明提供了可用作PDK1抑制剂的化合物。 本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。
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公开(公告)号：US20100144730A1
公开(公告)日：2010-06-10
申请号：US12307104
申请日：2007-07-02
Applicant: Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
Inventor： Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
IPC: A61K31/437 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/519 , A61K31/5377 , A61P35/00
CPC classification number: C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
Abstract: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
Abstract translation: 本发明提供吡啶基PDK1抑制剂和使用其制备癌症的方法。
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