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    Infection-resistant materials and method of making same through use of sulfonamides
    11.
    发明授权
    Infection-resistant materials and method of making same through use of sulfonamides 失效
    抗感染材料及其制备方法通过使用磺酰胺

    公开(公告)号：US4581028A

    公开(公告)日：1986-04-08

    申请号：US605793

    申请日：1984-04-30

    Applicant: Charles L. Fox, Jr. ,  Shanta Modak ,  Keith Reemtsma

    Inventor： Charles L. Fox, Jr. ,  Shanta Modak ,  Keith Reemtsma

    IPC: A61L17/00 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61F2/24 ,  A61F2/28 ,  A61F2/30 ,  A61K31/625

    CPC classification number: A61L31/16 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/404 ,  Y10S977/753

    Abstract: Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.

    Abstract translation: 感染抗性材料及其制备方法，适合在人体或动物体内部以血管移植假体或其它植入装置的形式使用。 通过加入其中的抗微生物剂，例如磺酰胺的金属盐和其他抗微生物剂或抗菌剂如哌拉西林，使该物质变得具有抗感染性。 在具体的示例性实施方案中，磺胺嘧啶银通过具有天然或合成聚合材料如丝，聚酯（例如，涤纶），聚氨酯，聚四氟乙烯或硅氧烷基材料的新技术络合，以提供长期预防可能的感染 结果在手术或植入装置期间或之后。

    Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids
    12.
    发明申请
    Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids 审中-公开
    包含抗感染化合物，辛氧基甘油，水杨酸和倍半萜烯的组合的抗菌药物

    公开(公告)号：US20060099237A1

    公开(公告)日：2006-05-11

    申请号：US11250241

    申请日：2005-10-14

    Applicant: Shanta Modak ,  Trupti Gaonkar

    Inventor： Shanta Modak ,  Trupti Gaonkar

    IPC: A61K33/38 ,  A61F13/00

    CPC classification number: A61L31/16 ,  A61K31/155 ,  A61K31/19 ,  A61K33/38 ,  A61K45/06 ,  A61L15/44 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/45 ,  A61K2300/00

    Abstract: Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), biomedical silicon, biodegradable polymers, polytetrafluoroethylene (PTFE), etc. or from natural products including natural rubber, silk or cotton fiber. Antimicrobial compositions comprising salicylic acid and sesquiterpenoids are also disclosed.

    Abstract translation: 公开了用含有辛氧基甘油和其它抗感染化合物的协同组合的抗微生物组合物浸渍的医疗制品。 这样的医疗制品可以包括导尿管，中心静脉导管，气管导管，动脉移植物，伤口敷料，缝合线或衍生自聚合物基底的生物医学聚氨酯，生物医学聚氯乙烯（PVC），生物医学硅，生物可降解聚合物，聚四氟乙烯 （PTFE）等，或天然橡胶，丝绸或棉纤维等天然产品。 还公开了包含水杨酸和倍半萜类化合物的抗微生物组合物。

    Gentle-acting skin disinfectants
    14.
    发明授权
    Gentle-acting skin disinfectants 有权
    温和的皮肤消毒剂

    公开(公告)号：US06846846B2

    公开(公告)日：2005-01-25

    申请号：US10047631

    申请日：2001-10-23

    Applicant: Shanta Modak ,  Trupti A. Gaonkar ,  Lester Sampath

    Inventor： Shanta Modak ,  Trupti A. Gaonkar ,  Lester Sampath

    IPC: A61K8/04 ,  A61K8/34 ,  A61K8/41 ,  A61K8/43 ,  A61K31/79 ,  A61Q17/00 ,  A61Q19/00 ,  A61K31/08 ,  A61K7/32 ,  A61K31/14 ,  A61K31/27

    CPC classification number: A61K8/042 ,  A61K8/347 ,  A61K8/416 ,  A61K8/43 ,  A61K31/79 ,  A61K2800/75 ,  A61Q17/005

    Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.

    Abstract translation: 在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。 在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。 优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。 不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。

    Tricolosan-containing medical devices
    15.
    发明授权
    Tricolosan-containing medical devices 有权
    含三环素的医疗器械

    公开(公告)号：US06626873B1

    公开(公告)日：2003-09-30

    申请号：US09618432

    申请日：2000-07-18

    Applicant: Shanta Modak ,  Lester Sampath

    Inventor： Shanta Modak ,  Lester Sampath

    IPC: A61M532

    CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1331 ,  Y10T428/1352 ,  A61L29/06 ,  C08L83/04 ,  C08L75/04 ,  A61L27/507

    Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.

    Abstract translation: 本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。 至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性 疏水聚合物。 也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。 根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

    Triclosan-containing medical devices
    16.
    发明授权
    Triclosan-containing medical devices 失效
    含三氯生的医疗器械

    公开(公告)号：US6106505A

    公开(公告)日：2000-08-22

    申请号：US101129

    申请日：1998-06-30

    Applicant: Shanta Modak ,  Lester Sampath

    Inventor： Shanta Modak ,  Lester Sampath

    IPC: A61L15/44 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M5/32

    CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1331 ,  Y10T428/1352

    Abstract: The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

    Abstract translation: PCT No.PCT / US96 / 20932 Sec。 371日期1998年6月30日第 102（e）日期1998年6月30日PCT 1996年12月23日PCT PCT。 公开号WO97 / 25085 日期1997年7月17日本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。 至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性 疏水聚合物。 也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。 根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

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