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公开(公告)号：US07993525B2
公开(公告)日：2011-08-09
申请号：US11647566
申请日：2006-12-29
Applicant: Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
Inventor： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
IPC: G01N1/00 , G01N21/00 , G01N33/48 , G01N33/53 , G01N33/553
CPC classification number: G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微机架阵列机械可移动的永磁体在功能上耦合到流体网络，其可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。
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公开(公告)号：US20110155586A1
公开(公告)日：2011-06-30
申请号：US12655578
申请日：2009-12-31
Applicant: Oguz H. Elibol , Jonathan S. Daniels , Grace M. Credo , Xing Su
Inventor： Oguz H. Elibol , Jonathan S. Daniels , Grace M. Credo , Xing Su
CPC classification number: G01N27/3278
Abstract: Devices and methods are presented for electronic sensing of chemical and biochemical analytes. An electronic sensor having a at least two electrodes separated by a nanoscale gap wherein the separation between the first electrode and the second electrode forms a cavity capable of containing a fluid wherein two or more posts comprised of an insulating material extend into the cavity from the face of the first electrode to the face of the second electrode. Optionally, the cavity is closed with a bead. Devices according to embodiments of the invention are capable of detecting chemicals and biochemicals through redox cycling events. Additionally, devices and methods according to embodiments of the invention are adapted to identify and sequence nucleic acid molecules.
Abstract translation: 介绍了化学和生物化学分析物的电子感应装置和方法。 一种电子传感器，具有由纳米尺度间隙分开的至少两个电极，其中第一电极和第二电极之间的间隔形成能够容纳流体的空腔，其中由绝缘材料构成的两个或更多个柱从表面延伸到空腔中 的第一电极到第二电极的表面。 可选地，空腔用珠封闭。 根据本发明的实施例的装置能够通过氧化还原循环事件来检测化学品和生物化学品。 另外，根据本发明的实施方案的装置和方法适于鉴定和序列核酸分子。
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13.发明申请ELECTRICALLY ACTIVE COMBINATORIAL CHEMICAL (EACC) CHIP FOR BIOCHEMICAL ANALYTE DETECTION 审中-公开用于生物化学分析检测的电活性组合化学（EACC）芯片公开(公告)号：US20110136693A1
公开(公告)日：2011-06-09
申请号：US12964814
申请日：2010-12-10
Applicant: Xing SU , Lei B. Sun , Jacque H. Georger, JR.
Inventor： Xing SU , Lei B. Sun , Jacque H. Georger, JR.
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00662 , B01J2219/00704 , B01J2219/00722 , B01L3/5085 , B01L2300/0636 , B01L2300/0819 , B82Y15/00 , B82Y30/00 , G01N33/5438 , C12Q2565/601
Abstract: Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.
Abstract translation: 公开了用于生化分析物检测的电活性组合化学（EACC）芯片的装置和方法。 一种装置包括具有限定多个细胞的区域阵列的基底，其中每个细胞包括含有多个功能性结合基团的反应腔。 一种检测在源极和漏极或一对电极之间提供反应腔的分析物的方法，施加电压并监测指示分析物特征的参数。 制备EACC的方法包括将分析物结合到每个反应腔的多个功能性结合基团，以及形成包括该基质的分析物感测结构。
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公开(公告)号：US07790286B2
公开(公告)日：2010-09-07
申请号：US12036869
申请日：2008-02-25
Applicant: Jingwu Zhang , Xing Su , Lei Sun
Inventor： Jingwu Zhang , Xing Su , Lei Sun
IPC: B32B5/16
CPC classification number: G01N21/658 , G01N2021/653 , G01N2021/655 , G01N2021/656 , Y10S977/773 , Y10S977/777 , Y10S977/783 , Y10T428/12049 , Y10T428/2991 , Y10T428/2998
Abstract: Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.
Abstract translation: 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。
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15.发明申请MICROFLUIDIC APPARATUS, SYSTEMS, AND METHODS FOR PERFORMING MOLECULAR REACTIONS 审中-公开用于实施分子反应的微流感设备，系统和方法公开(公告)号：US20100151454A1
公开(公告)日：2010-06-17
申请号：US12256409
申请日：2008-10-22
Applicant: Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
Inventor： Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
IPC: C12Q1/68
CPC classification number: C12Q1/6827 , C12Q1/6869 , G01N21/658 , Y10T436/11 , Y10T436/117497 , Y10T436/143333 , C12Q2565/629 , C12Q2521/319 , C12Q2565/632 , C12Q2565/619
Abstract: Disclosed herein are methods, apparatuses, and systems for performing nucleic acid sequencing reactions and molecular binding reactions in a microfluidic channel. The methods, apparatuses, and systems can include a restriction barrier to restrict movement of a particle to which a nucleic acid is attached. Furthermore, the methods, apparatuses, and systems can include hydrodynamic focusing of a delivery flow. In addition, the methods, apparatuses, and systems can reduce non-specific interaction with a surface of the microfluidic channel by providing a protective flow between the surface and a delivery flow.
Abstract translation: 本文公开了用于在微流体通道中进行核酸测序反应和分子结合反应的方法，装置和系统。 方法，装置和系统可以包括限制核酸附着的颗粒运动的限制障碍。 此外，方法，装置和系统可以包括输送流的流体动力聚焦。 此外，方法，装置和系统可以通过在表面和输送流之间提供保护流来减少与微流体通道的表面的非特异性相互作用。
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Patent Agency Ranking
16.发明申请Methods of producing carbon nanotubes using peptide or nucleic acid micropatterning 审中-公开使用肽或核酸微图案生产碳纳米管的方法公开(公告)号：US20090170725A1
公开(公告)日：2009-07-02
申请号：US11344713
申请日：2006-01-31
Applicant: Mineo Yamakawa , Yuegang Zhang , Xing Su , Lei Sun , Andrew A. Berlin , Narayanan Sundararajan
Inventor： Mineo Yamakawa , Yuegang Zhang , Xing Su , Lei Sun , Andrew A. Berlin , Narayanan Sundararajan
CPC classification number: B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
Abstract: The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles 140, 230 to polymer 120, 210 molecules, attaching the polymer 120, 210 molecules to a substrate, removing the polymer 120, 210 molecules and producing carbon nanotubes on the catalyst nanoparticles 140, 230. The polymer 120, 210 molecules can be attached to the substrate in ordered patterns, using self-assembly or molecular alignment techniques. The nanotube arrays can be attached to selected areas 110, 310 of the substrate. Within the selected areas 110, 310, the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
Abstract translation: 本文公开的方法，装置和系统涉及碳纳米管的有序阵列。 在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒140,230连接到聚合物120,210分子，将聚合物120,210分子连接到基底上的方法形成，除去聚合物120,210分子并产生碳 催化剂纳米颗粒140,230上的纳米管。聚合物120,210分子可以使用自组装或分子对准技术以有序图案附着到基底上。 纳米管阵列可以附着到基板的选定区域110,310。 在所选择的区域110,310内，纳米管是非随机分布的。 本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。 在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。
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公开(公告)号：US20090069481A1
公开(公告)日：2009-03-12
申请号：US12036869
申请日：2008-02-25
Applicant: Jingwu Zhang , Xing Su , Lei Sun
Inventor： Jingwu Zhang , Xing Su , Lei Sun
IPC: C08K3/10
CPC classification number: G01N21/658 , G01N2021/653 , G01N2021/655 , G01N2021/656 , Y10S977/773 , Y10S977/777 , Y10S977/783 , Y10T428/12049 , Y10T428/2991 , Y10T428/2998
Abstract: Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.
Abstract translation: 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。
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18.发明授权Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions 有权微流体装置，拉曼光谱系统和进行分子反应的方法公开(公告)号：US07442339B2
公开(公告)日：2008-10-28
申请号：US10815264
申请日：2004-03-31
Applicant: Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
Inventor： Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
CPC classification number: C12Q1/6827 , C12Q1/6869 , G01N21/658 , Y10T436/11 , Y10T436/117497 , Y10T436/143333 , C12Q2565/629 , C12Q2521/319 , C12Q2565/632 , C12Q2565/619
Abstract: Disclosed herein are methods, apparatuses, and systems for performing nucleic acid sequencing reactions and molecular binding reactions in a microfluidic channel. The methods, apparatuses, and systems can include a restriction barrier to restrict movement of a particle to which a nucleic acid is attached. Furthermore, the methods, apparatuses, and systems can include hydrodynamic focusing of a delivery flow. In addition, the methods, apparatuses, and systems can reduce non-specific interaction with a surface of the microfluidic channel by providing a protective flow between the surface and a delivery flow.
Abstract translation: 本文公开了用于在微流体通道中进行核酸测序反应和分子结合反应的方法，装置和系统。 方法，装置和系统可以包括限制核酸附着的颗粒运动的限制障碍。 此外，方法，装置和系统可以包括输送流的流体动力聚焦。 此外，方法，装置和系统可以通过在表面和输送流之间提供保护流来减少与微流体通道的表面的非特异性相互作用。
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19.发明授权Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 失效使用表面增强拉曼散射（SERS）进行生物分子检测的金属表面改性公开(公告)号：US07432112B2
公开(公告)日：2008-10-07
申请号：US11134747
申请日：2005-05-19
Applicant: Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
Inventor： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC: G01N33/553
CPC classification number: G01N21/658
Abstract: The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.
Abstract translation: 本发明基于这样的发现：本文所述的用于生产金属胶体的方法导致胶体表现出增加的信号增强和生物分子的SERS检测的再现性。 因此，使用本发明的方法，可以以更高的灵敏度和可靠性检测各种各样的生物分子。
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20.发明授权公开(公告)号：US07427513B2
公开(公告)日：2008-09-23
申请号：US11133707
申请日：2005-05-19
Applicant: Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
Inventor： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC: G01N33/553
CPC classification number: G01N21/658
Abstract: The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.
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