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公开(公告)号：US20160145558A1
公开(公告)日：2016-05-26
申请号：US14746494
申请日：2015-06-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： James Q. BOEDICKER , Rustem F. ISMAGILOV , Hyun Jung KIM
CPC classification number: C12M35/08 , C12M1/14 , C12M23/34 , C12M25/01 , C12N1/20 , C12N1/38 , C12N11/04 , C12P39/00 , C12Q1/18 , G01N33/542 , G01N33/54313
Abstract: This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
Abstract translation: 本发明提供了使微生物共孵育的装置和方法。 还提供了制造用于微生物共孵育的装置以及这种装置的各种应用的方法。
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公开(公告)号：US20130281316A1
公开(公告)日：2013-10-24
申请号：US13869856
申请日：2013-04-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SLIPCHIP, LLC
Inventor： Rustem F. ISMAGILOV , Feng CHEN
IPC: C12Q1/68
CPC classification number: C12Q1/686 , B01L3/502738 , B01L7/52 , B01L2200/0668 , B01L2200/0673 , B01L2300/0681 , B01L2300/069 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0409 , B01L2400/0487 , B01L2400/065
Abstract: The present invention relates to fluidic devices for compartmentalizing samples. In particular, the devices and related systems and methods allow for compartmentalization by using one or more first chambers connect by a first channel (e.g., where the cross-sectional dimension of the first channel is less than the cross-sectional dimension of at least one first chamber).
Abstract translation: 本发明涉及用于分隔样品的流体装置。 特别地，装置和相关系统和方法允许通过使用由第一通道连接的一个或多个第一室（例如，其中第一通道的横截面尺寸小于至少一个的横截面尺寸的区域） 第一室）。
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公开(公告)号：US20230212661A1
公开(公告)日：2023-07-06
申请号：US17861077
申请日：2022-07-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Bing SUN , Jesus RODRIGUEZ MANZANO , Eugenia KHOROSHEVA , Matthew S. CURTIS
IPC: C12Q1/6844 , C12Q1/70
CPC classification number: C12Q1/6844 , C12Q1/70
Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
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14.发明公开公开(公告)号：US20230183818A1
公开(公告)日：2023-06-15
申请号：US17264734
申请日：2019-08-01
Applicant: California Institute of Technology
Inventor： Rustem F. ISMAGILOV , Nathan SCHOEPP , Tahmineh KHAZAEI , Jacob T. BARLOW
CPC classification number: C12Q1/689 , C12Q1/04 , C12Q1/025 , C12Q2600/106 , C12Q2600/158
Abstract: Provided herein are RNA markers and compositions, methods and systems for the related identification and/or uses in methods for detection of antibiotic susceptibility and resistance in a microorganism, and in particular in N. gonorrhoeae.
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15.发明申请公开(公告)号：US20220282304A1
公开(公告)日：2022-09-08
申请号：US17683246
申请日：2022-02-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Eric LIAW , Anna E. ROMANO
Abstract: Provided herein is an antibiotic susceptibility and related compositions, methods and systems based on nucleic acid detection based on detected intracellular and extracellular nucleic acid from a same sample, which allows determination of antibiotic susceptibility of microorganisms as well as the diagnosis and/or treatment of related infections in individuals.
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Patent Agency Ranking
公开(公告)号：US20190352705A1
公开(公告)日：2019-11-21
申请号：US16224617
申请日：2018-12-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Bing SUN , Jesus RODRIGUEZ MANZANO , Eugenia KHOROSHEVA , Matthew S. CURTIS
IPC: C12Q1/6848 , C12Q1/70 , C12Q1/6865 , C12Q1/6844 , C12Q1/6851 , C12Q1/686
Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
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公开(公告)号：US20170152553A1
公开(公告)日：2017-06-01
申请号：US15030202
申请日：2014-10-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Bing SUN , Jesus RODRIGUEZ MANZANO , Eugenia KHOROSHEVA , Matthew S. CURTIS
CPC classification number: C12Q1/6848 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q1/6865 , C12Q1/707 , C12Q2527/125 , C12Q2565/501 , C12Q2531/119 , C12Q2565/629
Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
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公开(公告)号：US20160266105A1
公开(公告)日：2016-09-15
申请号：US15000864
申请日：2016-01-19
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF CHICAGO
Inventor： Rustem F. ISMAGILOV , Stephanie MCCALLA , Travis SCHLAPPI , Toan HUYNH , Justin ROLANDO , Weishan LIU , Shencheng GE , Jason E. KREUTZ
IPC: G01N33/543 , C12Q1/68 , B01L3/00
CPC classification number: G01N33/54366 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2200/0673 , B01L2300/0627 , B01L2300/069 , B01L2300/0803 , B01L2300/0816 , B01L2300/0819 , B01L2300/0893 , B01L2300/12 , B01L2300/165 , B01L2400/0644 , C12Q1/6844 , G01N33/54386
Abstract: Provided herein are methods, compositions, and devices for the identification and quantification of analytes, such as nucleic acids, proteins, cells or other biological samples. The methods, compositions, and devices are suited for accurate, portable analysis of small amounts of analyte.
Abstract translation: 本文提供了用于鉴定和定量分析物例如核酸，蛋白质，细胞或其他生物样品的方法，组合物和装置。 方法，组合物和装置适用于对少量分析物进行准确，便携的分析。
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公开(公告)号：US20160263577A1
公开(公告)日：2016-09-15
申请号：US15022879
申请日：2014-09-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SLIPCHIP CORPORATION
Inventor： Rustem F. ISMAGILOV , Feng SHEN , Liang LI , David SELCK , Joe BAKER , Espir KAHATT , Chris DA COSTA
CPC classification number: B01L3/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/523 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/047 , B01L2300/0672 , B01L2300/069 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/161 , B01L2300/1855 , B01L2300/1877 , B01L2400/0409 , B01L2400/043 , B01L2400/0457 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0493 , B01L2400/0644 , B01L2400/0677 , B01L2400/0683 , G01N1/4077
Abstract: The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.
Abstract translation: 本发明涉及用于控制一种或多种流体和/或一种或多种试剂的流体系统。 这些系统可以与用于测定，处理和/或存储样品的一个或多个装置组合使用。 特别地，系统和相关方法可以允许以受控的方式分配流体和/或在实施测定或过程时引入暂停。
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公开(公告)号：US20240034688A1
公开(公告)日：2024-02-01
申请号：US18228369
申请日：2023-07-31
Applicant: California Institute of Technology
Inventor： Katherine T. FABER , Julia A. KORNFIELD , Noriaki ARAI , Orland BATEMAN , Rustem F. ISMAGILOV
IPC: C04B38/06 , B01D67/00 , B01D69/02 , B01D71/02 , B01J35/04 , B01J35/10 , C04B38/00 , H01B1/14 , H01B1/16
CPC classification number: C04B38/0605 , B01D67/0051 , B01D69/02 , B01D71/024 , B01J35/04 , B01J35/1071 , B01J35/1076 , C04B38/0038 , C04B38/0054 , C04B38/007 , C04B38/0093 , H01B1/14 , H01B1/16 , B01D2325/021 , B01D2325/26
Abstract: Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material.
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