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公开(公告)号：US20110278214A1
公开(公告)日：2011-11-17
申请号：US12811158
申请日：2008-12-16
Applicant: Christopher C. Benevides , Keith Fadgen , Michael Lavallee , Anthony Jeannotte
Inventor： Christopher C. Benevides , Keith Fadgen , Michael Lavallee , Anthony Jeannotte
CPC classification number: B01D15/14 , B01D15/22 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , Y10T29/49826
Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.
Abstract translation: 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内部导管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。
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公开(公告)号：US09983178B2
公开(公告)日：2018-05-29
申请号：US14238278
申请日：2012-08-23
Applicant: Joseph D. Michienzi , Keith Fadgen , Wade P. Leveille, Sr. , Raymond P. Fisk , Frank John Marzalkowski, Jr.
Inventor： Joseph D. Michienzi , Keith Fadgen , Wade P. Leveille, Sr. , Raymond P. Fisk , Frank John Marzalkowski, Jr.
CPC classification number: B05B5/16 , B01D15/10 , B01D15/1871 , B01D15/22 , G01N30/60 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/7266 , Y10T29/49908
Abstract: Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.
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公开(公告)号：US20140053910A1
公开(公告)日：2014-02-27
申请号：US14114330
申请日：2012-04-24
Applicant: Bernard Bunner , Joseph Michienzi , Keith Fadgen
Inventor： Bernard Bunner , Joseph Michienzi , Keith Fadgen
CPC classification number: F16K3/10 , F16K3/18 , F16K31/041 , G01N35/1097 , G01N2030/202 , Y10T137/0318
Abstract: Described are a rotary shear seal valve and a method for switching a high pressure fluid. The method includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.
Abstract translation: 描述了一种旋转剪切密封阀和一种用于切换高压流体的方法。 该方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。
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公开(公告)号：US20130206240A1
公开(公告)日：2013-08-15
申请号：US13808263
申请日：2011-08-26
Applicant: Geoff C. Gerhardt , Keith Fadgen
Inventor： Geoff C. Gerhardt , Keith Fadgen
IPC: F16K11/00
CPC classification number: F16K11/00 , F16K11/0743 , Y10T137/0318 , Y10T137/86863
Abstract: Variable-volume injection valves include a stator and a rotor. The stator has a first port, a second port, and a contact surface with a groove therein. The first port opens into the stator groove. The rotor has a contact surface with a groove therein. The contact surface of the rotor is urged against the contact surface of the stator such that the rotor groove opposes the stator groove with one end of the rotor groove overlapping the stator groove and the opposite end of the rotor groove overlapping the second port of the stator. The overlapping grooves of the rotor and stator provide a fluidic channel between the first and second ports of the stator. The rotor is movable with respect to the stator in order to vary a length of overlap between their overlapping grooves.
Abstract translation: 可变容积喷射阀包括定子和转子。 定子具有第一端口，第二端口和与其中的凹槽的接触表面。 第一端口通向定子槽。 转子具有与其中的凹槽的接触表面。 转子的接触表面被推靠在定子的接触表面上，使得转子槽与定子槽相对，转子槽的一端与定子槽重叠，转子槽的相对端与定子的第二端重叠 。 转子和定子的重叠槽在定子的第一和第二端口之间提供流体通道。 转子可相对于定子移动，以便改变其重叠槽之间的重叠长度。
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公开(公告)号：US08394275B2
公开(公告)日：2013-03-12
申请号：US12811158
申请日：2008-12-16
Applicant: Christopher C. Benevides , Keith Fadgen , Michael Lavallee , Anthony Jeannotte
Inventor： Christopher C. Benevides , Keith Fadgen , Michael Lavallee , Anthony Jeannotte
IPC: B01D15/08
CPC classification number: B01D15/14 , B01D15/22 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , Y10T29/49826
Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.
Abstract translation: 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。
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Patent Agency Ranking
16.发明授权System and method of measuring convection induced impedance gradients to determine liquid flow rates 有权测量对流感应阻抗梯度以确定液体流速的系统和方法公开(公告)号：US06962077B2
公开(公告)日：2005-11-08
申请号：US10328986
申请日：2002-12-23
Applicant: Geoff C. Gerhardt , Keith Fadgen
Inventor： Geoff C. Gerhardt , Keith Fadgen
CPC classification number: G01F1/6847 , G01N30/64 , G01N2030/324
Abstract: A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.
Abstract translation: 一种用于利用位于中心的激励源和多个传感器装置来测量流动通道内的液体或气体的流量的方法和系统。 所述激励装置包括与交流发电机耦合的加热元件。 在多个传感器装置中，至少一个所述传感器位于激励源位置的上游位置，并且所述多个传感器中的另一个位于激发源的下游位置。 利用电耦合到所述传感器的高增益差分放大器来计算瞬时流体流速，其中流动流体的对流感应感应梯度与对称零流感应梯度进行比较。 在进行这样的比较之后，导出与通道内的流体流量成比例的电压信号。
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公开(公告)号：US20140151541A1
公开(公告)日：2014-06-05
申请号：US14004236
申请日：2012-03-08
Applicant: Geoff C. Gerhardt , Keith Fadgen
Inventor： Geoff C. Gerhardt , Keith Fadgen
IPC: H01J49/00
CPC classification number: H01J49/0009 , H01J49/00 , H01J49/04
Abstract: An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user-friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.
Abstract translation: 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效的固态切换。
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18.发明授权Device and methods for reducing pressure and flow perturbations in a chromatographic system 有权降低色谱系统压力和流动扰动的装置和方法公开(公告)号：US08312762B2
公开(公告)日：2012-11-20
申请号：US12282895
申请日：2007-03-16
Applicant: Keith Fadgen , James E. Usowicz , Miguel Soares
Inventor： Keith Fadgen , James E. Usowicz , Miguel Soares
IPC: G01M30/02
CPC classification number: G01N30/20 , G01N30/22 , G01N2030/201 , G01N2030/202 , G05D7/0688 , G05D16/208
Abstract: Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.
Abstract translation: 本发明的实施方案涉及将样品置于色谱系统中的方法和装置。 该装置和方法的特征是将放置样品回路中的样品置于加压之前，使样品环与高压导管连通。
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19.发明授权System and method of measuring convection induced impedance gradients to determine liquid flow rates 失效测量对流感应阻抗梯度以确定液体流速的系统和方法公开(公告)号：US07059185B2
公开(公告)日：2006-06-13
申请号：US11088120
申请日：2005-03-22
Applicant: Geoff C. Gerhardt , Keith Fadgen
Inventor： Geoff C. Gerhardt , Keith Fadgen
IPC: G01F1/68
CPC classification number: G01F1/6847 , G01N30/64 , G01N2030/324
Abstract: A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensors. The excitation source is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensors, at least one of the sensors is located in a position upstream of the excitation source location, and additionally a second of the plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to the sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.
Abstract translation: 一种用于利用位于中心的激发源和多个传感器来测量流动通道内的液体或气体的流量的方法和系统。 激发源由与交流发电机耦合的加热元件组成。 在多个传感器中，传感器中的至少一个位于激励源位置的上游位置，另外多个传感器中的第二传感器位于激励源的下游位置。 利用电耦合到传感器的高增益差分放大器计算瞬时流体流速，其中将流动流体的对流感应感应梯度与对称零流感应梯度进行比较。 在进行这样的比较之后，导出与通道内的流体流量成比例的电压信号。
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公开(公告)号：US09396916B2
公开(公告)日：2016-07-19
申请号：US14004236
申请日：2012-03-08
Applicant: Geoff C. Gerhardt , Keith Fadgen
Inventor： Geoff C. Gerhardt , Keith Fadgen
CPC classification number: H01J49/0009 , H01J49/00 , H01J49/04
Abstract: An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user-friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.
Abstract translation: 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效固态切换。
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