公开(公告)号：US12251701B2

公开(公告)日：2025-03-18

申请号：US16768881

申请日：2018-10-03

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Hilary Ely ,  Michael W. Cumbie ,  Adam Higgins ,  Rachel M. White ,  Erik D. Torniainen

IPC: C12P19/34 ,  B01L3/00 ,  B01L7/00

Abstract: A fluid thermal processing device may include a substrate, a platform projecting from the substrate, a fluid heating element supported by the platform, a temperature sensing element, distinct from the fluid heating element, supported by the platform and an enclosure supported by and cooperating with the substrate to form a fluid chamber about the platform. The fluid chamber forms a volume of uniform thickness conforming to and about the platform.

公开(公告)号：US12233415B2

公开(公告)日：2025-02-25

申请号：US17417306

申请日：2019-04-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Si-lam Choy ,  Hilary Ely ,  John Lahmann

IPC: B01L3/00 ,  A61L27/16 ,  A61L27/56 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B01L7/00 ,  B01L9/00 ,  B23Q17/24 ,  C07K14/705 ,  C08F220/56 ,  C08L33/26 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/6844 ,  C12Q1/686 ,  G01N1/31 ,  G01N21/17 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: Examples herein involve amplification and detection of nucleic acids using a microfluidic reaction chamber. An example apparatus includes a reaction-chamber circuit to process a reagent and a biologic sample for amplification of nucleic acids. The apparatus further includes a plurality of capillaries to pass the reagent and the biologic sample through the microfluidic reaction chamber. A valve control system may selectively control each of a plurality of valves to cause the reagent and the biologic sample to selectively move through the microfluidic reaction chamber for the amplification of the nucleic acids according to a particular timing sequence. In various examples, a trapping region disposed in the microfluidic reaction chamber secures the nucleic acids in the microfluidic reaction chamber for amplification using the reaction-chamber circuit.

公开(公告)号：US11761459B2

公开(公告)日：2023-09-19

申请号：US16768883

申请日：2018-01-16

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Hilary Ely ,  Pavel Kornilovich ,  Daniel Curthoys

IPC: F04F7/00 ,  B01L3/00 ,  F04B43/04 ,  F04B23/04

CPC classification number: F04F7/00 ,  B01L3/50273 ,  F04B23/04 ,  F04B43/046 ,  B01L2300/0663 ,  B01L2400/0406 ,  B01L2400/0487

Abstract: A fluidic device may include a vertical fluid dispensing volume having a side outlet, a fluid channel connected to the vertical fluid dispensing volume below the side outlet and a fluid actuator asymmetrically located between ends of the fluid channel to form an inertial pump to vertically pump fluid within the channel to the side outlet.

公开(公告)号：US11590495B2

公开(公告)日：2023-02-28

申请号：US16619508

申请日：2017-07-28

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Hilary Ely ,  Matthew David Smith ,  Jeremy Sells ,  George H. Corrigan ,  Michael W. Cumbie ,  Chantelle Domingue

IPC: C12Q1/6876 ,  B01L3/00 ,  B01L7/00 ,  G01N21/64

Abstract: A method may include maintaining a sample comprising an ionic species and an optical indicator at an elevated temperature above 25° C. on a semi-conductive microfluidic die during an incubation period, intermittently interrogating the sample with an interrogating light during the incubation period and sensing a response of the sample to the interrogating light, wherein the sample is interrogated with the interrogating light only during those times at which the sample is being sensed.

公开(公告)号：US11203017B2

公开(公告)日：2021-12-21

申请号：US16099668

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Jeffrey A Nielsen ,  Manish Giri ,  Chantelle Domingue ,  Kenneth Ward ,  Christie Dudenhoefer ,  Matthew David Smith ,  Joshua M. Yu ,  Diane R. Hammerstad ,  Hilary Ely

IPC: B01L3/00 ,  B01L3/02 ,  G01N15/10 ,  G01N35/10 ,  G01N15/14

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

公开(公告)号：US11179720B2

公开(公告)日：2021-11-23

申请号：US16319702

申请日：2016-10-07

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Manish Giri ,  Chantelle Domingue ,  Tod Woodford ,  Matthew David Smith ,  Rachel M. White ,  Joshua M. Yu ,  Hilary Ely ,  Jeremy Sells

IPC: B01L3/00 ,  F16K99/00

Abstract: The present disclosure is drawn to microfluidic chips. The microfluidic chips can include an inflexible material having an elastic modulus of 0.1 gigapascals (GPa) to 450 GPa. A microfluidic channel can be formed within the inflexible material and can connect an inlet and an outlet. A working electrode can be associated with the microfluidic channel and can have a surface area of 1 μm2 to 60,000 μm2 within the microfluidic channel. A bubble support structure can also be formed within the microfluidic channel such that the working electrode is positioned to electrolytically generate a bubble that becomes associated with the bubble support structure.

公开(公告)号：US11135579B2

公开(公告)日：2021-10-05

申请号：US16099478

申请日：2016-07-13

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Diane R. Hammerstad ,  Matthew David Smith ,  Hilary Ely

IPC: B01L3/02 ,  B01L3/00 ,  B01L9/00

Abstract: An apparatus includes a media that includes an encoded pattern to indicate a location of each of a plurality of dispensing locations on a receiving area for a pipette dispenser. The encoded pattern is employed to guide the pipette dispenser to dispense a volume to a selected dispensing location from the plurality of dispensing locations based on a predetermined dispensing location on the receiving area.