Glycosylated human interferon alpha isoform
    13.
    发明申请
    Glycosylated human interferon alpha isoform 失效
    糖基化人类干扰素α同种型

    公开(公告)号:US20050019871A1

    公开(公告)日:2005-01-27

    申请号:US10653350

    申请日:2003-09-02

    IPC分类号: C07K14/56 C12P21/02 C07H21/04

    CPC分类号: C07K14/56

    摘要: The present invention relates to an amino acid-modified human interferon alpha isoform having at least one of the Asn-Xaa-Ser/Thr (N-X-S/T) sequence formed at a specific site so that glycosylation takes place at this site and a gene encoding the same, an expression vector comprising the gene, and a method for producing glycosylated human interferon alpha isoform by transforming or transfecting an eukaryotic cell with the expression vector, culturing the transfected or transformed cell and isolating the glycosylated human interferon alpha isoform from the culture, the glycosylated human interferon alpha isoform produced therefrom and a pharmaceutical composition comprising the same.

    摘要翻译: 本发明涉及具有在特定部位形成的至少一种Asn-Xaa-Ser / Thr(NXS / T)序列的氨基酸修饰的人类干扰素α同种型,使得在该位点发生糖基化,并编码基因 相同的包含该基因的表达载体和通过用表达载体转化或转染真核细胞来产生糖基化的人干扰素α同种型的方法,培养转染或转化的细胞并从培养物中分离糖基化的人干扰素α同种型, 由其制备的糖基化的人干扰素α同种型和包含其的药物组合物。

    Semiconductor integrated circuit
    16.
    发明授权
    Semiconductor integrated circuit 失效
    半导体集成电路

    公开(公告)号:US08421528B2

    公开(公告)日:2013-04-16

    申请号:US13097326

    申请日:2011-04-29

    IPC分类号: G05F1/10

    摘要: A semiconductor integrated circuit includes a first voltage line to which a first ground voltage is applied, a second voltage line to which a second ground voltage is applied, a third voltage line to which a first power supply voltage is applied, and a coupling unit including a MOS transistor having a source coupled to the first voltage line, a drain coupled to the second voltage line, and a gate coupled to the third voltage line.

    摘要翻译: 半导体集成电路包括施加第一接地电压的第一电压线,施加第二接地电压的第二电压线,施加第一电源电压的第三电压线,以及包括 MOS晶体管,其具有耦合到第一电压线的源极,耦合到第二电压线的漏极和耦合到第三电压线的栅极。

    Liquid crystal display device and driving method thereof
    18.
    发明授权
    Liquid crystal display device and driving method thereof 有权
    液晶显示装置及其驱动方法

    公开(公告)号:US07385583B2

    公开(公告)日:2008-06-10

    申请号:US10954944

    申请日:2004-09-30

    IPC分类号: G09G3/36 G09G5/10

    摘要: An apparatus and a method of driving a liquid crystal display device includes generating a first control signal and a second control signal using a vertical synchronization signal and a horizontal synchronization signal, respectively; applying a scan pulse to gate lines depending on the first control signal; applying data to source lines depending on the second control signal; and driving a backlight unit in accordance with a change of state of at least one of the first control signal and the second control signal.

    摘要翻译: 驱动液晶显示装置的装置和方法包括分别使用垂直同步信号和水平同步信号产生第一控制信号和第二控制信号; 根据第一控制信号将扫描脉冲施加到栅极线; 根据第二控制信号将数据应用于源极线; 以及根据所述第一控制信号和所述第二控制信号中的至少一个的状态的改变来驱动背光单元。

    Glycosylated human granulocyte colony-stimulating factor (G-CSF) isoform
    19.
    发明授权
    Glycosylated human granulocyte colony-stimulating factor (G-CSF) isoform 失效
    糖基化的人粒细胞集落刺激因子(G-CSF)同种型

    公开(公告)号:US07344858B2

    公开(公告)日:2008-03-18

    申请号:US10651395

    申请日:2003-08-29

    CPC分类号: C07K14/535 A61K38/00

    摘要: Disclosed are human G-CSF isoforms having a modified amino acid sequence containing a glycosylation sequence Asn-X-Ser/Thr (N-X-S/T) at one or more specific amino acid positions according to the present invention, genes encoding the human G-CSF isoforms, and expression vectors carrying the genes, eukaryotic cells transformed or transfected with the expression vectors. Also, the present invention discloses a method of preparing a glycosylated human G-CSF isoform, comprising the steps of culturing the transformant or transfectant and isolating a glycosylated human G-CSF isoform from the culture supernatant or cell lysates, a human G-CSF isoform prepared by the method, and a pharmaceutical composition comprising the human G-CSF isoform.

    摘要翻译: 公开了具有在本发明的一个或多个特定氨基酸位置上含有糖基化序列Asn-X-Ser / Thr(NXS / T)的修饰氨基酸序列的人G-CSF同种型,编码人G-CSF的基因 同种型和携带基因的表达载体,用表达载体转化或转染的真核细胞。 此外,本发明公开了一种制备糖基化的人G-CSF同工型的方法,其包括培养转化体或转染子并从培养上清或细胞裂解物,人G-CSF同工型分离糖基化的人G-CSF同种型的步骤 通过该方法制备,以及包含人G-CSF同种型的药物组合物。