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公开(公告)号：US20190205768A1
公开(公告)日：2019-07-04
申请号：US16224496
申请日：2018-12-18
Applicant: IMEC vzw
Inventor： Tim Stakenborg , Chang Chen , Kris Covens , Qing Cai , Maarten Fauvart
Abstract: A method for writing data including a sequence of bits, the data being written in a form of DNA, by in-vitro enzymatically producing memory DNA from a strand of memory writing substrate DNA is disclosed. In one aspect, the method includes repeating of: receiving a sub-sequence of the sequence of bits, the sub-sequence including at least one bit; selecting memory nucleotides based on the sub-sequence; contacting, in liquid medium including the strand of memory writing substrate DNA contacted with an enzyme, the selected memory nucleotides and the enzyme; and synthesizing a portion of the memory DNA from a portion of the strand of memory writing substrate DNA by the enzyme and at least one of the memory nucleotides of the solution, thereby producing memory DNA including memory nucleotides corresponding to bits of the sequence of bits. The disclosed technology further relates to a micro-fluidic system including a microfluidic chip and a controller.
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公开(公告)号：US20180345287A1
公开(公告)日：2018-12-06
申请号：US16059576
申请日：2018-08-09
Applicant: IMEC VZW
Inventor： Paolo Fiorini , Tim Stakenborg , Frederik Colle
CPC classification number: B01L3/502784 , B01L7/52 , B01L2200/061 , B01L2200/0673 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/1827 , C12Q1/686
Abstract: A micro-fluidic device 100 for performing digital PCR is presented. The device comprises: a semiconductor substrate; a first micro-fluidic channel 104, comprising an inlet 102 and an outlet 103, embedded in the semiconductor substrate; a heating element 101 thermally coupled to the first micro-fluidic channel 104; a droplet generator 107 connected to the inlet 102 of the first micro-fluidic channel 104 for generating droplets and pumping generated droplets at a flow rate into the first micro-fluidic channel 104; characterized in that: the heating element 101 is a single heating element connected to a temperature control unit 111 configured to cycle the temperature of the complete first micro-fluidic channel 104 through at least two temperature values; and wherein the flow rate of the droplet generator 107 is adaptable. Further, a method to perform digital PCR is presented using the micro-fluidic device 100.
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公开(公告)号：US09373519B2
公开(公告)日：2016-06-21
申请号：US14560202
申请日：2014-12-04
Applicant: IMEC VZW
Inventor： Karolien Jans , Alexandra Dusa , Tim Stakenborg
IPC: H01L21/306 , H01L21/308 , H01L29/06 , H01L21/3205 , H01L21/32 , G01N33/487 , B82Y40/00
CPC classification number: H01L21/3085 , B81B2207/056 , B81C1/00206 , B82Y40/00 , G01N33/487 , H01L21/3086 , H01L21/32 , H01L21/32051 , H01L29/06
Abstract: A method for creating a pattern on a substrate (101) is presented, the method comprises: providing a substrate (101) comprising silicon; creating a sacrificial layer (102) on the substrate (101), wherein the sacrificial layer is formed on a first surface area (101a) of the substrate thereby leaving a second surface area (101b) exposed; depositing a first functional layer (103) at least on the second surface area (101b) of the substrate (101); removing the sacrificial layer (102); wherein: removing the sacrificial layer (102) is performed by etching the sacrificial layer (102) with an acidic aqueous solution that does not adversely affect the first functional layer (103) and the substrate (101).
Abstract translation: 提出了一种用于在衬底（101）上形成图案的方法，所述方法包括：提供包括硅的衬底（101）; 在所述基板（101）上形成牺牲层（102），其中所述牺牲层形成在所述基板的第一表面区域（101a）上，从而使第二表面区域（101b）露出; 至少在基板（101）的第二表面区域（101b）上沉积第一功能层（103）; 去除牺牲层（102）; 其中：通过用对第一功能层（103）和衬底（101）不产生不利影响的酸性水溶液蚀刻牺牲层（102）来进行去除牺牲层（102）。
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公开(公告)号：US11276003B2
公开(公告)日：2022-03-15
申请号：US16224496
申请日：2018-12-18
Applicant: IMEC vzw
Inventor： Tim Stakenborg , Chang Chen , Kris Covens , Qing Cai , Maarten Fauvart
Abstract: A method for writing data including a sequence of bits, the data being written in a form of DNA, by in-vitro enzymatically producing memory DNA from a strand of memory writing substrate DNA is disclosed. In one aspect, the method includes repeating of: receiving a sub-sequence of the sequence of bits, the sub-sequence including at least one bit; selecting memory nucleotides based on the sub-sequence; contacting, in liquid medium including the strand of memory writing substrate DNA contacted with an enzyme, the selected memory nucleotides and the enzyme; and synthesizing a portion of the memory DNA from a portion of the strand of memory writing substrate DNA by the enzyme and at least one of the memory nucleotides of the solution, thereby producing memory DNA including memory nucleotides corresponding to bits of the sequence of bits. The disclosed technology further relates to a micro-fluidic system including a microfluidic chip and a controller.
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公开(公告)号：US11266990B2
公开(公告)日：2022-03-08
申请号：US16059576
申请日：2018-08-09
Applicant: IMEC VZW
Inventor： Paolo Fiorini , Tim Stakenborg , Frederik Colle
Abstract: A micro-fluidic device 100 for performing digital PCR is presented. The device comprises: a semiconductor substrate; a first micro-fluidic channel 104, comprising an inlet 102 and an outlet 103, embedded in the semiconductor substrate; a heating element 101 thermally coupled to the first micro-fluidic channel 104; a droplet generator 107 connected to the inlet 102 of the first micro-fluidic channel 104 for generating droplets and pumping generated droplets at a flow rate into the first micro-fluidic channel 104; characterized in that: the heating element 101 is a single heating element connected to a temperature control unit 111 configured to cycle the temperature of the complete first micro-fluidic channel 104 through at least two temperature values; and wherein the flow rate of the droplet generator 107 is adaptable. Further, a method to perform digital PCR is presented using the micro-fluidic device 100.
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Patent Agency Ranking
公开(公告)号：US11130124B2
公开(公告)日：2021-09-28
申请号：US15737013
申请日：2016-06-20
Applicant: IMEC VZW
Inventor： Benjamin Jones , Tim Stakenborg , Paolo Fiorini
Abstract: A fluidic device is described for locally coating an inner surface of a fluidic channel. The fluidic device comprises a first, a second and a third fluidic channel intersecting at a common junction. The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device further comprises a fluid control means configured for creating a fluidic flow path for a coating fluid at the common junction such that, when coating, a coating fluid propagates from the first to the second fluidic channel via the common junction without propagating into the third fluidic channel. A corresponding method for coating and for sensing also has been disclosed.
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公开(公告)号：US20210199211A1
公开(公告)日：2021-07-01
申请号：US17135192
申请日：2020-12-28
Applicant: IMEC VZW
Inventor： Lei Zhang , Tim Stakenborg , Chengxun Liu , David Cheyns
IPC: F16K31/128 , F16K7/12 , F16K11/24 , F16K31/00 , F16K7/10
Abstract: Example embodiments relate to microfluidic devices for controlling pneumatic microvalves. One embodiment includes a microfluidic device for independently controlling a plurality of pneumatic microvalves. The microfluidic device is couplable to a pressure source. The microfluidic device includes a first substrate. The microfluidic device also includes a flexible membrane covering the first substrate. Additionally, the microfluidic device includes a second substrate covering the flexible membrane. Further, the microfluidic device includes one or more fluidic channels at least partially defined in the first substrate. In addition, the microfluidic device includes a pressure couplable to the pressure source and branching into a plurality of pressure channels. Still further, the microfluidic device includes at least one pressure control switch per pressure channel.
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公开(公告)号：US10359363B2
公开(公告)日：2019-07-23
申请号：US15736414
申请日：2016-06-22
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.
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公开(公告)号：US20180188176A1
公开(公告)日：2018-07-05
申请号：US15737747
申请日：2016-06-29
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
CPC classification number: G01N21/6452 , G01N21/1717 , G01N21/6428 , G01N21/6456 , G01N21/648 , G01N2021/1731 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439
Abstract: A sensor device for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector for obtaining an at least one dimensional pattern of measured signals, wherein the detector is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.
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公开(公告)号：US20180169652A1
公开(公告)日：2018-06-21
申请号：US15737013
申请日：2016-06-20
Applicant: IMEC VZW
Inventor： Benjamin Jones , Tim Stakenborg , Paolo Fiorini
IPC: B01L3/00
CPC classification number: B01L3/502707 , B01J2219/00353 , B01J2219/00389 , B01J2219/00414 , B01J2219/00418 , B01J2219/00637 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/16 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B05C7/04 , F16K99/0021
Abstract: A fluidic device is described for locally coating an inner surface of a fluidic channel. The fluidic device comprises a first, a second and a third fluidic channel intersecting at a common junction. The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device further comprises a fluid control means configured for creating a fluidic flow path for a coating fluid at the common junction such that, when coating, a coating fluid propagates from the first to the second fluidic channel via the common junction without propagating into the third fluidic channel. A corresponding method for coating and for sensing also has been disclosed.
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