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    NOISE REDUCTION FOR ANALYTE DETECTION SYSTEMS
    12.
    发明申请
    NOISE REDUCTION FOR ANALYTE DETECTION SYSTEMS 审中-公开
    用于分析仪检测系统的噪声减少

    公开(公告)号：US20070258083A1

    公开(公告)日：2007-11-08

    申请号：US11734261

    申请日：2007-04-11

    申请人： Kevin Heppell ,  James Braig

    发明人： Kevin Heppell ,  James Braig

    IPC分类号： G01N33/48

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  G01N21/07 ,  G01N21/274 ,  G01N21/35

    摘要： Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. Some embodiments use a synchronous demodulator and digital filter to reduce microphonic signal content. Some embodiments monitor the microphonic signal content and “hold off” on making a measurement until vibrations subside. Monitoring can be performed using an accelerometer or other vibration sensor. An algorithm can be used to examine the detector output signal and detect excessive microphonic components, making an accelerometer unnecessary.

    摘要翻译： 提供了用于确定样品（例如体液样品中的分析物）中的分析物的浓度的方法和装置。 一些实施例使用同步解调器和数字滤波器来减少麦克风信号内容。 一些实施例监视麦克风信号内容并在进行测量时“保持”，直到振动消退。 可以使用加速度计或其他振动传感器进行监视。 可以使用一种算法来检测检测器输出信号并检测过多的麦克风分量，使加速度计不必要。

    Spectroscopic analysis of a biological fluid reacted with an enzyme
    13.
    发明申请
    Spectroscopic analysis of a biological fluid reacted with an enzyme 审中-公开
    与酶反应的生物液体的光谱分析

    公开(公告)号：US20060292650A1

    公开(公告)日：2006-12-28

    申请号：US11438902

    申请日：2006-05-23

    申请人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

    发明人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

    IPC分类号： C12Q1/54 ,  C12M1/34

    CPC分类号： C12Q1/26 ,  C12Q1/32 ,  C12Q1/52 ,  C12Q1/54

    摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.

    摘要翻译： 提出了使用组合酶分光法估计分析物浓度的装置。 提供葡萄糖和乳酸盐检测的实例。 将生物流体样品与特定于目标分析物的酶混合或接触，并且反应流体用波长包括至少一种对分析物浓度敏感的波长和至少一种波长的光学系统进行探测 对分析物浓度不敏感。 光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。 还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。 这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

    Analyte detection system for multiple analytes
    15.
    发明申请
    Analyte detection system for multiple analytes 有权
    多种分析物的分析物检测系统

    公开(公告)号：US20060189858A1

    公开(公告)日：2006-08-24

    申请号：US11314176

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    发明人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    IPC分类号： A61B5/00 ,  A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。 在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

    Sample element qualification
    17.
    发明申请
    Sample element qualification 审中-公开
    样品单元鉴定

    公开(公告)号：US20050036146A1

    公开(公告)日：2005-02-17

    申请号：US10824933

    申请日：2004-04-15

    申请人： James Braig ,  Kenneth Witte ,  Philip Hartstein ,  Ken Li ,  Peter Rule

    发明人： James Braig ,  Kenneth Witte ,  Philip Hartstein ,  Ken Li ,  Peter Rule

    IPC分类号： G01N21/03 ,  G01N21/59 ,  G01N21/86 ,  G01N35/00 ,  G01N21/00

    CPC分类号： G01N35/00732 ,  G01N21/03 ,  G01N21/5907 ,  G01N21/8483 ,  G01N2035/00752 ,  G01N2035/00762 ,  G01N2035/00772 ,  G01N2035/00782

    摘要： A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.

    摘要翻译： 样品元件包括由中间构件分隔开的第一和第二基本上平行的面。 平行面和中间构件至少部分地限定了构造成保持一定体积的流体的样品室。 样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。 样本元件还包括设置在至少一个平行面内或之中的识别化合物。 识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。 通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

    Analyte detection system with periodic sample draw and body fluid analyzer
    18.
    发明申请
    Analyte detection system with periodic sample draw and body fluid analyzer 审中-公开
    分析物检测系统，定期抽样和体液分析仪

    公开(公告)号：US20070179435A1

    公开(公告)日：2007-08-02

    申请号：US11316212

    申请日：2005-12-21

    申请人： James Braig ,  Peter Rule

    发明人： James Braig ,  Peter Rule

    IPC分类号： A61M31/00 ,  G01N33/487 ,  A61B5/00

    CPC分类号： A61B5/1486 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B2562/0295 ,  A61M5/14232 ,  A61M2005/1726 ,  A61M2230/201 ,  G01N27/3271 ,  G01N33/49

    摘要： An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.

    摘要翻译： 用于分析患者体液的系统的实施例包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。 泵系统耦合到流体输送网络。 泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体 运输网络通过病人端。 至少一个电化学测试元件位于流体输送网络的流体输送点附近。 电化学测试元件被定位成接收由流体输送网络输送到输送点的体液的一部分。 分析物检测系统被配置为接收测试元件并测量体液部分中的至少一种分析物。

    Analyte detection system with interferent identification and correction
    19.
    发明申请
    Analyte detection system with interferent identification and correction 审中-公开
    分析物检测系统具有干扰物识别和校正

    公开(公告)号：US20070103678A1

    公开(公告)日：2007-05-10

    申请号：US11314803

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Richard Keenan ,  Richard King

    发明人： Bernhard Sterling ,  W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Richard Keenan ,  Richard King

    IPC分类号： G01J3/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient. The apparatus further comprises a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer configured to obtain spectra from at least a portion of the sample, and a processor in communication with or incorporated into the spectroscopic analyzer. The apparatus further comprises stored program instructions executable by the processor to (a) identify one or more interferents to the measurement of one or more analytes in the bodily fluid as being possibly present in the portion, and (b) reduce errors in the measurement due to the presence of the determined possible interferents. The pump unit can comprise a single dual-mode or reversible pump operable in both the infusion and sample draw modes; or two pumps, one of which is operable in the infusion mode but not in the sample draw mode, and another of which is operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端。 该装置还包括与流体处理网络有效接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 该装置还包括分光分析器，被配置为从样品的至少一部分获得光谱，以及与光谱分析仪连通或结合到光谱分析仪中的处理器。 所述装置还包括可由所述处理器执行的存储的程序指令，以（a）识别对所述部分中可能存在的所述体液中的一种或多种分析物的测量的一个或多个干扰物，以及（b）减少所述测量中的误差 确定可能的干扰物的存在。 泵单元可以包括可在输液和抽样模式中操作的单个双模式或可逆泵; 或两个泵，其中一个可在输液模式中操作，但不在样品抽取模式中，另一个在样品抽取模式中可操作，但不在输注模式中。