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11.发明申请公开(公告)号：US20140315743A1
公开(公告)日：2014-10-23
申请号：US14348930
申请日：2012-10-03
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to methods, compositions and kits for the diagnosis, detection, and treatment of ovarian cancer.
摘要翻译： 本发明涉及用于诊断，检测和治疗卵巢癌的方法，组合物和试剂盒。
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公开(公告)号：US20140206574A1
公开(公告)日：2014-07-24
申请号：US14240698
申请日：2012-08-31
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria J. Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria J. Prendes
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57488 , C12Q1/6886 , G01N33/57484 , G01N33/6893
摘要： The invention relates to methods of detecting cancer in a sample obtained from a subject. The invention also provides kits and reagents for detecting cancer as well as therapeutics and methods of treating cancer.
摘要翻译： 本发明涉及从受试者获得的样品中检测癌症的方法。 本发明还提供用于检测癌症的试剂盒和试剂，以及治疗和治疗癌症的方法。
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13.发明申请Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques 审中-公开使用核转移技术产生免疫兼容细胞和组织的方法公开(公告)号：US20120246746A1
公开(公告)日：2012-09-27
申请号：US13108666
申请日：2011-05-16
申请人： Robert Lanza , Michael West
发明人： Robert Lanza , Michael West
CPC分类号： C12N15/873 , A01K67/0271 , A01K2217/05 , A01K2227/101 , A01K2227/105 , A01K2267/025 , A61K49/0008 , C12N15/8771 , C12N2517/04
摘要： This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.
摘要翻译： 本发明涉及使用核转移和克隆技术制备用于移植和组织工程的免疫相容性组织和细胞的方法。 还包括确定表达的转基因对工程细胞和组织的免疫相容性和其他遗传操作的影响的方法。
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14.发明申请Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby 审中-公开从多能干细胞和由此获得的细胞中加速分离新细胞株的方法公开(公告)号：US20080070303A1
公开(公告)日：2008-03-20
申请号：US11604047
申请日：2006-11-21
申请人： Michael West , Geoffrey Sargent , James Murai , Steven Kessler , Karen Chapman
发明人： Michael West , Geoffrey Sargent , James Murai , Steven Kessler , Karen Chapman
CPC分类号： C12N5/0662 , A61K35/30 , A61K35/34 , A61K35/39 , A61K35/407 , C12N5/0606 , C12N5/0619 , C12N5/0652 , C12N5/0657 , C12N5/067 , C12N5/0676 , C12N2506/02
摘要： This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
摘要翻译： 本发明一般涉及区分多能干细胞（例如胚胎干，胚胎胚芽或胚源性细胞）的方法，以从细胞的不均匀混合物获得细胞亚群，其中与原始多能性相比，细胞亚群具有降低的分化潜能 干细胞和亚群能够传播的地方。
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15.发明申请Therapy and diagnosis of conditions related to telomere length and/or telomerase activity 审中-公开治疗和诊断与端粒长度和/或端粒酶活性有关的病症公开(公告)号：US20060172960A1
公开(公告)日：2006-08-03
申请号：US11181020
申请日：2005-07-12
申请人： Michael West , Jerry Shay , Woodring Wright
发明人： Michael West , Jerry Shay , Woodring Wright
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , A61K38/00 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2501/70 , C12N2510/04 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Q2600/112 , C12Q2600/136 , C12Y207/07049 , G01N2333/91245 , Y02A50/409 , Y02A50/411 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831 , C12Q2521/113
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
摘要翻译： 提供了测定端粒长度和端粒酶活性的方法和组合物，以及抑制端粒酶活性治疗增殖性疾病的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓衰老细胞中端粒重复的丧失的手段。
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公开(公告)号：US20060133964A1
公开(公告)日：2006-06-22
申请号：US11254030
申请日：2005-10-18
申请人： Thomas Bailey , Michael Ahern , Michael West , Qin Wang , Zhenbiao Wang , James Tappan
发明人： Thomas Bailey , Michael Ahern , Michael West , Qin Wang , Zhenbiao Wang , James Tappan
IPC分类号： G01N33/00
CPC分类号： G01N31/02 , G01N1/34 , G01N1/4077 , H01J49/04 , Y10T436/25375
摘要： An automated matrix removal module is configurable to automatically withdraw a portion of sample containing an interfering matrix. The module is further configurable to mix the portion of sample with a reagent selected to react with the matrix to form a precipitant and then filter the mixture of sample and precipitant reagent through a filter. Finally, the module is further configurable to flush the precipitant from the filter.
摘要翻译： 自动矩阵去除模块可配置为自动提取包含干扰矩阵的样本的一部分。 该模块进一步可配置以将样品的一部分与选择与基质反应的试剂混合以形成沉淀剂，然后通过过滤器过滤样品和沉淀剂的混合物。 最后，该模块进一步可配置以从过滤器冲洗沉淀剂。
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17.发明申请Analysis of semiconductor copper plating bath chemistry using in process mass spectrometry 审中-公开使用过程质谱分析半导体铜电镀液化学公开(公告)号：US20060128028A1
公开(公告)日：2006-06-15
申请号：US11352550
申请日：2006-02-13
申请人： Marc Anderson , Michael West , James Tappan
发明人： Marc Anderson , Michael West , James Tappan
IPC分类号： G01N24/00
CPC分类号： G01N35/1097 , G01N30/24 , G01N2030/201 , G01N2030/202 , Y10T436/24
摘要： An in-process mass spectrometry (IPMS) system is disclosed that uses an internal standard to determine the concentration of an analyte in a sample. The internal standard has a different molecular composition than the analyte but is sufficiently similar chemically and physically to the analyte such that it behaves substantially the same as the analyte during an ionization process in the mass spectrometer.
摘要翻译： 公开了一种使用内部标准来确定样品中分析物浓度的过程中质谱（IPMS）系统。 内标与分析物具有不同的分子组成，但与分析物的化学和物理性质充分相似，使得其在质谱仪的离子化过程中与分析物基本上相同。
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公开(公告)号：US20060112438A1
公开(公告)日：2006-05-25
申请号：US11028345
申请日：2005-01-03
申请人： Michael West , Karen Chapman , Irina Klimanskaya
发明人： Michael West , Karen Chapman , Irina Klimanskaya
IPC分类号： A01K67/027 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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19.发明申请Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells 审中-公开用于促进从胚胎和成体多能细胞和多能细胞分化细胞类型和组织的产生的方法公开(公告)号：US20050153443A1
公开(公告)日：2005-07-14
申请号：US10948841
申请日：2004-09-23
申请人： Robert Lanza , Michael West
发明人： Robert Lanza , Michael West
IPC分类号： A61K35/12 , C12N5/0735 , C12N5/08
CPC分类号： C12N5/0606 , A61K35/12 , C12N2502/1394 , C12N2502/28
摘要： The invention is concerned with producing differentiated cells, tissues and organs from pluripotent and mutlipotent cells. The methods of the invention are particularly useful for producing differentiated cells from pluripotent cells wherein communication between the cells of more than one embryonic germ layer or more than one organ system are required for development along a specific cell lineage. The invention methods are effected by in vivo or in vitro culturing of embryonic and developing or developed allogeneic or xenogeneic cells.
摘要翻译： 本发明涉及从多能细胞和多能细胞产生分化的细胞，组织和器官。 本发明的方法特别可用于从多能细胞产生分化的细胞，其中需要多于一个胚胎胚层或更多个器官系统的细胞之间的连通以沿特定细胞谱系发育。 本发明方法通过体内或体外培养胚胎和发育或发育的同种异体或异种细胞来实现。
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公开(公告)号：US20140349396A1
公开(公告)日：2014-11-27
申请号：US14238160
申请日：2012-09-10
申请人： Michael West , James T Murai , Jay Yang
发明人： Michael West , James T Murai , Jay Yang
IPC分类号： C12N5/0735 , C12N5/071
CPC分类号： C12N5/0606 , C12N5/0658 , C12N5/069 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2506/02 , C12N2506/28
摘要： Aspects of the present invention include methods and compositions related to the production and use of clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells. In particular, said methods and compositions relate to methods of differentiating cells in the presence of agents that inhibit the signaling of the TGF beta family members of growth factors and the applications of said cell lines in the treatment of diseases such as degenerative muscle disorders, cancer, and vascular disease.
摘要翻译： 本发明的方面包括与来源于原始干细胞的分化培养物的胚胎祖细胞系的克隆谱系的生产和使用相关的方法和组合物。 特别地，所述方法和组合物涉及在抑制生长因子的TGFβ家族成员的信号传导的药剂存在下分化细胞的方法以及所述细胞系在治疗诸如退行性肌肉障碍，癌症的疾病中的应用 ，和血管疾病。
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