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51 条记录 (耗时 0.041 秒)

    Crosslinkable macromers
    14.
    发明授权
    Crosslinkable macromers 有权
    可交联的大分子单体

    公开(公告)号：US07547445B2

    公开(公告)日：2009-06-16

    申请号：US11475438

    申请日：2006-06-27

    申请人： Stephen J. Chudzik ,  Joseph A. Chinn

    发明人： Stephen J. Chudzik ,  Joseph A. Chinn

    IPC分类号： A61F2/02 ,  A61F2/06 ,  A61F2/28 ,  A61F13/00

    CPC分类号： A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  Y10S623/92 ,  Y10S623/926

    摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more multifunctional initiator groups. The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

    摘要翻译： 一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。 大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个多官能引发剂基团。 当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。 大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。 本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。 在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

    Glycerol ester active agent delivery systems and methods
    15.
    发明授权
    Glycerol ester active agent delivery systems and methods 有权
    甘油酯活性剂递送系统及方法

    公开(公告)号：US08871819B2

    公开(公告)日：2014-10-28

    申请号：US13104383

    申请日：2011-05-10

    申请人： Emily R. R. Meyering ,  Stephen J. Chudzik

    发明人： Emily R. R. Meyering ,  Stephen J. Chudzik

    IPC分类号： A01N25/00 ,  A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L67/00

    摘要： Embodiments of the invention include glycerol esters and use of the same for active agent delivery systems and methods. In an embodiment, the invention includes an active agent eluting device including a glycerol ester, an active agent dispersed within the glycerol ester, the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. In an embodiment, the invention includes a composition including a glycerol ester; an active agent dispersed within the glycerol ester; the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. Other embodiments are also included herein.

    摘要翻译： 本发明的实施方案包括甘油酯和其用于活性剂递送系统和方法的用途。 在一个实施方案中，本发明包括活性剂洗脱装置，其包括甘油酯，分散在甘油酯内的活性剂，所述活性剂洗脱装置构造成响应于甘油酯的降解而从甘油酯中洗脱活性剂。 在一个实施方案中，本发明包括包含甘油酯的组合物; 分散在甘油酯内的活性剂; 活性剂洗脱装置构造成响应于甘油酯的降解而从甘油酯洗脱活性剂。 本文还包括其它实施例。

    Hydrogel-based joint repair system and method
    16.
    发明授权
    Hydrogel-based joint repair system and method 有权
    基于水凝胶的关节修复系统及方法

    公开(公告)号：US08242179B2

    公开(公告)日：2012-08-14

    申请号：US11821466

    申请日：2007-06-22

    申请人： Stephen J. Chudzik

    发明人： Stephen J. Chudzik

    IPC分类号： A61K47/34

    CPC分类号： A61L27/52 ,  A61F2/441 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3008 ,  A61F2002/30291 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2210/0061 ,  A61F2230/0091 ,  A61F2250/0098 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L2430/38 ,  C08L33/08 ,  C08L71/02 ,  C08L5/08

    摘要： The invention provides a system and method for treating an orthopedic condition using a hydrogel-forming composition, which forms a hydrogel in situ at a target location and at least bio-mechanically treats the condition. The invention also provides a hydrogel forming composition designed to form a hydrogel with desirable biocompatible and biomechanical properties. In some aspects the hydrogel is formed in a water-permeable casing, which is delivered to an orthopedic joint in a minimally invasive manner. In particular, the system and method can be used for intervertebral disc replacement or repair.

    摘要翻译： 本发明提供了一种使用水凝胶形成组合物治疗整形外科病症的系统和方法，其在目标位置原位形成水凝胶，并且至少生物机械处理该病症。 本发明还提供了一种设计成形成具有所需生物相容性和生物力学性质的水凝胶的水凝胶形成组合物。 在一些方面，水凝胶形成在透水的外壳中，其以微创方式递送至矫形关节。 具体来说，系统和方法可用于椎间盘置换或修复。

    Crosslinkable macromers
    20.
    发明授权
    Crosslinkable macromers 有权

    公开(公告)号：US07094418B2

    公开(公告)日：2006-08-22

    申请号：US10990582

    申请日：2004-11-17

    申请人： Stephen J. Chudzik ,  David L. Clapper

    发明人： Stephen J. Chudzik ,  David L. Clapper

    IPC分类号： A61F2/06 ,  A61F2/28 ,  A61F13/00

    CPC分类号： A61K9/1647 ,  A61K9/1641 ,  A61K38/1875 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L27/34 ,  A61L29/085 ,  A61L31/148 ,  Y10S623/92 ,  Y10S623/921 ,  Y10S623/923 ,  Y10S623/926

    摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.