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公开(公告)号:US20150299787A1
公开(公告)日:2015-10-22
申请号:US14754231
申请日:2015-06-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Wolfgang HINZ , David LIGHT , Todd REARICK , James A. BALL
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , G01N27/4145
Abstract: The disclosure relates to novel particle compositions and methods of making said compositions having applications in nucleic acid analysis, as well as apparatuses and systems for the same.
Abstract translation: 本公开涉及新型颗粒组合物和制备所述组合物在核酸分析中的应用的方法,以及用于其的装置和系统。
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公开(公告)号:US20240125733A1
公开(公告)日:2024-04-18
申请号:US18475640
申请日:2023-09-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Ronald L. CICERO , James A. BALL , Alexander MASTROIANN1 , Christina E. INMAN , Jeremy GRAY , Marc GLAZER , Yufang WANG , Joseph KOSCINSKI , Phil WAGGONER
IPC: G01N27/414
CPC classification number: G01N27/4145
Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.
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公开(公告)号:US20210129192A1
公开(公告)日:2021-05-06
申请号:US17079756
申请日:2020-10-26
Applicant: Life Technologies Corporation
Inventor: James A. BALL , Phil WAGGONER , Scott T. PARKER
IPC: B08B3/08 , B08B9/08 , C11D3/16 , G01N27/414 , C11D3/34 , C11D3/43 , C11D1/22 , C11D11/00 , H01L21/02
Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
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公开(公告)号:US20200282336A1
公开(公告)日:2020-09-10
申请号:US16786913
申请日:2020-02-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Brian REED , James A. BALL
IPC: B01D17/04 , C07H1/06 , C07H21/00 , C12Q1/6806
Abstract: A method of recovering a bead support from an emulsion includes supplying an aqueous surfactant solution into a centrifuge tube; supplying a hydrophobic liquid over the surfactant solution in the centrifuge tube, wherein a ratio of the volume of the aqueous surfactant solution to the volume of the hydrophobic liquid is not greater than 0.5; and applying an emulsion over the hydrophobic liquid while centrifuging, the emulsion comprising a dispersed aqueous phase including the bead support, the emulsion breaking and material of the dispersed phase preferentially partitioning to the surfactant solution.
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公开(公告)号:US20170095841A1
公开(公告)日:2017-04-06
申请号:US15387591
申请日:2016-12-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: James A. BALL , Phil WAGGONER , Scott PARKER
CPC classification number: B08B3/08 , B05D3/00 , B05D5/12 , B08B9/08 , C11D1/22 , C11D3/162 , C11D3/3418 , C11D3/43 , C11D7/34 , C11D7/5013 , C11D7/5022 , C11D11/0047 , G01N27/414 , G01N27/4145 , G01N27/4148 , H01L21/02057
Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
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公开(公告)号:US20160061773A1
公开(公告)日:2016-03-03
申请号:US14779517
申请日:2014-03-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: James A. BALL , Brian REED
IPC: G01N27/414 , C11D7/50 , C11D7/34 , B08B3/08
CPC classification number: G01N27/4145 , B08B3/08 , B08B9/08 , C11D3/162 , C11D3/3418 , C11D3/43 , C11D7/34 , C11D7/5013 , C11D7/5022 , C11D7/5027
Abstract: A sensor array includes a plurality of sensors. A sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array. A method of treating the sensor array includes exposing at least the sensor pad to a wash solution including sulfonic acid and an organic solvent and rinsing the wash solution from the sensor pad.
Abstract translation: 传感器阵列包括多个传感器。 多个传感器的传感器具有暴露在传感器阵列的表面处的传感器垫。 处理传感器阵列的方法包括将至少传感器垫暴露于包括磺酸和有机溶剂的洗涤溶液中,并从传感器垫冲洗洗涤溶液。
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公开(公告)号:US20150361488A1
公开(公告)日:2015-12-17
申请号:US14742404
申请日:2015-06-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Jonathan SCHULTZ , Todd ROSWECH , Jon A. HOSHIZAKI , Albert L. CARRILLO , James A. BALL
IPC: C12Q1/68 , G01N27/414
CPC classification number: C12Q1/6869 , B01F1/0027 , B01F5/0683 , B01F11/0048 , B01F11/0071 , B01L3/502 , B01L3/505 , B01L3/527 , B01L3/563 , B01L2200/04 , B01L2200/16 , B01L2300/022 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0683 , C12Q1/6806 , G01N27/4145 , G01N35/1002 , G01N35/1095 , Y10T436/11 , Y10T436/143333
Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.
Abstract translation: 制备试剂的方法包括将药筒插入仪器中。 盒包括设置在盒的空腔中并将端口暴露于盒的外部的多个试剂盒。 每个试剂盒包括试剂容器,其包括试剂和限定可压缩体积的内腔,通过试剂容器限定到内腔的开口。 该方法还包括将多个流体端口连接到多个试剂盒的开口; 通过所述流体端口施加溶液以至少部分地填充所述多个试剂外壳; 并且循环空腔的压力,由此对于每个试剂外壳,在增加的压力期间,溶液进入试剂容器的内腔,与试剂结合,并压缩可压缩体积,并且在减压期间,可压缩体积 减少,试剂通过开口排出。
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公开(公告)号:US20250043342A1
公开(公告)日:2025-02-06
申请号:US18920456
申请日:2024-10-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Philip WAGGONER , James A. BALL , Michael L. MINTO , David M. COX , Wolfgang HINZ , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Scott PARKER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号:US20240309443A1
公开(公告)日:2024-09-19
申请号:US18407234
申请日:2024-01-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Philip WAGGONER , James A. BALL , Michael L. MINTO , David M. COX , Wolfgang HINZ , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Scott PARKER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
CPC classification number: C12Q1/6869 , G01N27/4145
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号:US20200055097A1
公开(公告)日:2020-02-20
申请号:US16663099
申请日:2019-10-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: James A. BALL , Phil WAGGONER , Scott PARKER
IPC: B08B3/08 , H01L21/02 , G01N27/414 , C11D11/00 , C11D1/22 , C11D3/43 , C11D3/34 , C11D3/16 , B08B9/08
Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
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