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11.
公开(公告)号:US09040691B2
公开(公告)日:2015-05-26
申请号:US14130586
申请日:2012-06-26
申请人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süβmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
发明人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süβmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
IPC分类号: C07D487/04 , C07D401/04 , A61K31/53 , A61K31/4427 , A61P25/02 , A61P27/02 , A61K31/5377
CPC分类号: A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要: This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
摘要翻译: 本发明涉及式(I)的新的5 - [(羟甲基)芳基] - 取代的吡咯并[2,1-f] [1,2,4]三嗪-4-胺,用于制备这些化合物, 含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗血管生成相关病症,特别是血管发生相关性眼部疾病的用途。
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公开(公告)号:US08524722B2
公开(公告)日:2013-09-03
申请号:US12678288
申请日:2008-09-02
申请人: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
发明人: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
IPC分类号: A01N43/54 , A01N43/40 , A61K31/505 , A61K31/445 , C07D239/00 , C07D471/00 , C07D491/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号: C07D495/14 , C07D491/147 , C07D519/00
摘要: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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13.
公开(公告)号:US08501755B2
公开(公告)日:2013-08-06
申请号:US12225285
申请日:2007-03-20
申请人: Chengzhi Zhang , Kanwar Sidhu , Mario Lobell , Gaetan Ladouceur , Qian Zhao , Zheng Liu , Kristen M. Allegue , Chetan P. Darne , Jason Newcom
发明人: Chengzhi Zhang , Kanwar Sidhu , Mario Lobell , Gaetan Ladouceur , Qian Zhao , Zheng Liu , Kristen M. Allegue , Chetan P. Darne , Jason Newcom
IPC分类号: A61K31/519 , C07D471/14
CPC分类号: C07D495/14
摘要: This invention relates to compounds of Formula (I), wherein the variables are as disclosed in the specification, to pharmaceutical compositions containing them, to methods of making the compounds and pharmaceutical compositions, and to methods of using the compounds and pharmaceutical compositions for treating or preventing disorders, in particular cancer.
摘要翻译: 本发明涉及式(I)化合物,其中变量如本说明书中所公开的,含有它们的药物组合物,制备化合物和药物组合物的方法,以及使用该化合物和药物组合物治疗或 预防疾病,特别是癌症。
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14.Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity 审中-公开
标题翻译: 用于治疗高增殖性疾病和与丝裂原细胞外激酶活性相关的疾病的取代的苯基氨基苯衍生物公开(公告)号:US20090082328A1
公开(公告)日:2009-03-26
申请号:US12151855
申请日:2008-05-09
申请人: Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
发明人: Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
IPC分类号: A61K31/445 , C07C205/45 , C07D211/32 , C07C255/58 , C07D317/30 , C07C237/28 , A61K31/397 , A61K31/40 , A61K31/27 , A61P35/00 , A61K31/44 , A61K31/166 , C07D295/14 , C07D279/12 , C07D265/30 , A61K31/54 , A61K31/5375
CPC分类号: C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译: 本发明涉及新的取代的苯基氨基苯化合物,含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍,作为唯一试剂或与其它活性成分组合的用途。
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15.SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY 审中-公开
标题翻译: 用于治疗与增殖细胞激酶活性相关的超增殖性疾病和疾病的替代苯甲酰苯胺衍生物公开(公告)号:US20110071125A1
公开(公告)日:2011-03-24
申请号:US12599641
申请日:2008-05-09
申请人: Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
发明人: Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
IPC分类号: A61K31/4178 , C12N9/99 , A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445 , A61K31/425 , A61K31/385 , A61K31/17 , A61K31/165 , C07D295/12 , C07D241/04 , C07D211/30 , C07D277/04 , C07D403/12 , C07D327/04 , C07C273/00 , C07C233/00 , A61P35/00 , A61P27/12
CPC分类号: C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译: 本发明涉及新的取代的苯基氨基苯化合物,含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍,作为唯一试剂或与其它活性成分组合的用途。
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16.NOVEL SULPHOXIMINE-SUBSTITUTED QUINOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS 失效
标题翻译: 新型磺酰嘧啶取代的喹啉和喹唑啉衍生物作为激酶抑制剂公开(公告)号:US20090226377A1
公开(公告)日:2009-09-10
申请号:US12126437
申请日:2008-05-23
申请人: Knut EIS , Olaf Prien , Ulrich Lucking , Judith Gunther , Dieter Zopf , Dirk Brohm , Verena Vohringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
发明人: Knut EIS , Olaf Prien , Ulrich Lucking , Judith Gunther , Dieter Zopf , Dirk Brohm , Verena Vohringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
IPC分类号: A61K49/04 , C07D239/94 , A61K31/517 , A61K31/47 , C07D215/44 , A61P9/00 , C12Q1/02 , C12N9/99
CPC分类号: C07D239/86 , C07D215/44 , C07D409/04
摘要: The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译: 本发明涉及具有通式(A)的喹啉或喹唑啉衍生物:其中R3,R4,W,Y和Q在说明书和权利要求中表示,通式(A)的化合物的用途, 用于治疗各种疾病,以及制备通式(A)的化合物。
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公开(公告)号:US20060047123A1
公开(公告)日:2006-03-02
申请号:US11218396
申请日:2005-09-02
申请人: Saleh Ahmed , Celine Combet , Scott Cuthill , Graham Dawson , William Gattrell , Mario Lobell , Neil Pegg , Imaad Saba , Simon Swain , Claire Thomas , Graham Wynne
发明人: Saleh Ahmed , Celine Combet , Scott Cuthill , Graham Dawson , William Gattrell , Mario Lobell , Neil Pegg , Imaad Saba , Simon Swain , Claire Thomas , Graham Wynne
IPC分类号: C07D333/22 , C07D277/18 , C07D263/02
CPC分类号: C07D213/40 , C07C323/32 , C07C323/60 , C07C327/32 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/06 , C07D233/54 , C07D235/30 , C07D249/08 , C07D263/10 , C07D277/04 , C07D277/46 , C07D277/62 , C07D285/135 , C07D295/088 , C07D295/135 , C07D295/185 , C07D307/52 , C07D307/81 , C07D309/12 , C07D319/18 , C07D333/20 , C07D409/04 , C07D417/04 , C07D513/04
摘要: Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): or a pharmaceutically acceptable salt thereof, inhibit histone deacetylase enzyme and are useful for the treatment and/or prevention of various infections, cancerous diseases, and conditions.
摘要翻译: 由式(IA),(IB),(IIA)和(IIB)表示的巯丙酰胺化合物或其药学上可接受的盐抑制组蛋白脱乙酰酶,并且可用于治疗和/或预防各种感染,癌性疾病 和条件。
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18.
公开(公告)号:US20140256718A1
公开(公告)日:2014-09-11
申请号:US14130586
申请日:2012-06-26
申请人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süssmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
发明人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süssmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
IPC分类号: A61K31/5377 , C07D487/04 , A61K31/53
CPC分类号: A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要: This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
摘要翻译: 本发明涉及式(I)的新的5 - [(羟甲基)芳基] - 取代的吡咯并[2,1-f] [1,2,4]三嗪-4-胺,用于制备这些化合物, 含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗血管生成相关病症,特别是血管发生相关性眼部疾病的用途。
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19.Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases 失效
标题翻译: 吡咯并[2,1-F] [1,2,4]三嗪-4-基胺IGF-1R激酶抑制剂治疗癌症和其他过度增生性疾病公开(公告)号:US20110294776A1
公开(公告)日:2011-12-01
申请号:US12084411
申请日:2006-11-02
申请人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号: A61K31/53 , C07D498/04 , A61P35/00 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D487/04 , A61K31/5377
CPC分类号: C07D487/04
摘要: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译: 本发明涉及新的式(I)化合物。 式(I)其中可变基团如说明书和权利要求中所定义,含有它们的药物组合物,以及使用它们治疗癌症的方法。
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20.Sulphoximine-substituted quinoline and quinazoline derivatives as kinase inhibitors 失效
标题翻译: 磺酰亚胺取代的喹啉和喹唑啉衍生物作为激酶抑制剂公开(公告)号:US08003787B2
公开(公告)日:2011-08-23
申请号:US12126437
申请日:2008-05-23
申请人: Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
发明人: Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
IPC分类号: C07D239/86
CPC分类号: C07D239/86 , C07D215/44 , C07D409/04
摘要: The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译: 本发明涉及具有通式(A)的喹啉或喹唑啉衍生物:其中R3,R4,W,Y和Q在说明书和权利要求中表示,通式(A)的化合物的用途, 用于治疗各种疾病,以及制备通式(A)的化合物。
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