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公开(公告)号：US20190060458A1
公开(公告)日：2019-02-28
申请号：US15927730
申请日：2018-03-21
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Sayda M. ELBASHIR
IPC: A61K47/18 , A61K31/7115 , C12N15/87 , C12N15/67 , C12N9/64 , A61K38/19 , A61K31/7088 , A61K47/28 , A61K47/22 , A61K38/48 , C07K14/535 , A61K48/00
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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12.发明申请公开(公告)号：US20180311381A1
公开(公告)日：2018-11-01
申请号：US15790246
申请日：2017-10-23
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: A61K48/00 , C12P21/00 , C12P13/04 , C12N15/87 , C12N15/85 , C12N15/52 , C12N15/11 , C12N9/00 , C12N9/88 , C12N9/64 , C12N9/68 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/12 , C12N9/10 , C12N9/02 , C07K16/40 , C07K16/28 , C07K16/00 , C07K14/745 , C07K14/705 , C07K14/62 , C07K14/61 , C07K14/56 , C07K14/54 , C07K14/535 , C07K14/525 , C07K14/515 , C07K14/505 , C07K14/495 , C07K14/485 , C07K14/475 , C07K14/47 , C07K14/435 , C07K14/005 , C07H21/02 , A61K38/48 , A61K38/45 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7115 , A61K9/51 , A61K9/14 , A61K9/127 , A61K47/54 , A61K38/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20180170990A1
公开(公告)日：2018-06-21
申请号：US15662090
申请日：2017-07-27
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD , Ron WEISS , Kristy M. WOOD
IPC: C07K14/535 , A61K48/00 , C07K14/745 , C07K16/28 , C07K16/32 , C12N9/02 , C12N9/64 , A61K38/19 , A61K38/21 , A61K38/36 , A61K38/44 , A61K38/48 , A61K39/395 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/75 , A61K47/10 , A61K38/18 , A61K38/17 , A61K9/14 , C07K14/47 , C12N15/85 , A61K9/50 , A61K9/127
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20240123035A1
公开(公告)日：2024-04-18
申请号：US18177455
申请日：2023-03-02
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Kristy M. Wood , Sayda M. ELBASHIR , Noubar B. Afeyan , Pedro VALENCIA , Jason P. SCHRUM
IPC: A61K38/19 , A61K9/00 , A61K9/127 , A61K9/14 , A61K9/16 , A61K31/7088 , A61K31/7105 , A61K38/48 , A61K48/00 , C07K2/00 , C07K14/535 , C12N15/00 , C12N15/117 , C12N15/88 , C12P21/00
CPC classification number: A61K38/193 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/1271 , A61K9/1272 , A61K9/14 , A61K9/16 , A61K9/1647 , A61K31/7088 , A61K31/7105 , A61K38/4833 , A61K48/00 , A61K48/0033 , A61K48/0041 , A61K48/005 , A61K48/0066 , C07K2/00 , C07K14/535 , C12N15/00 , C12N15/117 , C12N15/88 , C12P21/00
Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
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Patent Agency Ranking
公开(公告)号：US20220273555A1
公开(公告)日：2022-09-01
申请号：US16860121
申请日：2020-04-28
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20190240351A1
公开(公告)日：2019-08-08
申请号：US15789138
申请日：2017-10-20
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Jeff Lynn ELLSWORTH , Kenechi EJEBE , Justin GUILD , Matthias JOHN , Paul HATALA , Atanu ROY , Jason P. SCHRUM , Susan WHORISKEY , Kristy M. WOOD
IPC: A61K48/00 , C07K14/535 , C07K14/47 , C07K14/515 , A61K9/127 , C12N9/64 , A61K31/7115 , A61K47/54 , A61K9/51 , A61K9/14 , C12N15/87 , C12N15/85 , C12N9/00 , C07K14/705 , C07K14/62 , C07K14/505 , C07K14/485 , C07K14/435 , A61K38/45 , A61K38/17 , A61K38/48 , C07K14/525 , C07K14/56 , C07K16/00 , C12P21/00 , A61K38/18 , A61K38/19 , A61K38/21 , C12P13/04 , C12N15/52 , C12N15/11 , C12N9/88 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/10 , C07K14/005
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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17.发明申请公开(公告)号：US20180086807A1
公开(公告)日：2018-03-29
申请号：US15440523
申请日：2017-02-23
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: C07K14/535 , A61K9/127 , C12N15/88 , C12N15/85 , C12N9/64 , C12N9/02 , C07K19/00 , C07K16/32 , C07K16/28 , C07K14/75 , C07K14/745 , C07K14/565 , C07K14/56 , C07K14/525 , C07K14/505 , C07K14/475 , C07K14/47 , A61K48/00 , A61K47/10 , A61K39/395 , A61K38/48 , A61K38/44 , A61K38/36 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7088 , A61K9/50 , A61K9/14 , A61K9/00
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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18.发明申请公开(公告)号：US20180002393A1
公开(公告)日：2018-01-04
申请号：US15425813
申请日：2017-02-06
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: C07K14/535 , C12N15/88 , C12N15/85 , C12N9/64 , C12N9/02 , C07K19/00 , C07K16/32 , C07K16/28 , C07K14/75 , C07K14/745 , C07K14/565 , C07K14/56 , C07K14/525 , C07K14/505 , C07K14/475 , C07K14/47 , A61K48/00 , A61K47/60 , A61K47/10 , A61K39/395 , A61K38/48 , A61K38/44 , A61K38/36 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7088 , A61K9/50 , A61K9/14 , A61K9/127 , A61K9/00
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/0043 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/145 , A61K9/5031 , A61K31/7088 , A61K31/7115 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/60 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022 , A61K2300/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
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公开(公告)号：US20170028085A1
公开(公告)日：2017-02-02
申请号：US15294339
申请日：2016-10-14
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. Wood , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD , Ron WEISS
IPC: A61K48/00 , A61K9/50 , C07K14/535 , A61K38/19 , A61K38/48 , C07K14/505 , A61K38/18 , C07K14/525 , C07K14/565 , A61K38/21 , C07K16/32 , A61K39/395 , C07K16/28 , C07K14/475 , A61K38/44 , C07K14/56 , C07K14/745 , A61K38/36 , C07K14/75 , C12N9/64 , C12N9/02 , A61K9/127
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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