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公开(公告)号:US20100160263A1
公开(公告)日:2010-06-24
申请号:US12617111
申请日:2009-11-12
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy Nagavelli , Karen Stepleton , Tad Warchol , Paul Sheahan
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy Nagavelli , Karen Stepleton , Tad Warchol , Paul Sheahan
IPC分类号: A61K31/65 , C07C237/26 , C07D403/10 , C07D213/30 , C07D215/14 , A61P31/00
CPC分类号: C07C237/26 , B32B37/0007 , B32B37/003 , B32B37/1284 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D209/48 , C07D213/82 , C07D215/14 , C07D307/24 , C07D317/60
摘要: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明涉及新的7,9-取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US20090325908A1
公开(公告)日:2009-12-31
申请号:US12351405
申请日:2009-01-09
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US20050026875A1
公开(公告)日:2005-02-03
申请号:US10737361
申请日:2003-12-15
申请人: Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人: Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
IPC分类号: C07D295/14 , A61K31/65 , A61P1/02 , A61P1/04 , A61P1/12 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/02 , A61P13/10 , A61P15/00 , A61P15/14 , A61P17/00 , A61P17/02 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/06 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C237/26 , C07C275/34 , C07C323/60 , C07D207/06 , C07D207/16 , C07D207/20 , C07D207/327 , C07D207/335 , C07D207/40 , C07D207/404 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/56 , C07D213/74 , C07D213/82 , C07D213/89 , C07D231/12 , C07D233/36 , C07D261/10 , C07D261/14 , C07D261/18 , C07D263/22 , C07D277/14 , C07D277/20 , C07D277/42 , C07D277/56 , C07D295/18 , C07D295/20 , C07D307/54 , C07D317/66 , C07D211/06 , C07D265/30
CPC分类号: C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译: 讨论了氨基甲基取代的四环素化合物,药物组合物及其使用方法。
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公开(公告)号:US06683068B2
公开(公告)日:2004-01-27
申请号:US09895797
申请日:2001-06-29
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy , Karen Stapleton , Tad Warchol , Paul Sheahan
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy , Karen Stapleton , Tad Warchol , Paul Sheahan
IPC分类号: A61K3165
CPC分类号: C07C237/26 , B32B37/0007 , B32B37/003 , B32B37/1284 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D209/48 , C07D213/82 , C07D215/14 , C07D307/24 , C07D317/60
摘要: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明涉及新的7,9-取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US5436108A
公开(公告)日:1995-07-25
申请号:US259556
申请日:1994-06-14
申请人: James R. Freedman , Marcis M. Kampe , Peter Viski , Kent M. Young
发明人: James R. Freedman , Marcis M. Kampe , Peter Viski , Kent M. Young
CPC分类号: G03C1/4989 , B41M2205/02 , B41M5/32 , B41M5/385 , G03C1/49809 , Y10S430/165
摘要: A thermographic dye transfer image-recording material is provided wherein a particular silver salt complex is employed as a source of silver ions, made available upon imagewise heating, to cleave a dye-providing material to provide a diffusible dye in an imagewise pattern corresponding to said imagewise heating. The silver salt complexes have improved solubility in the system providing for enhanced transferred image density.
摘要翻译: 提供了一种热成像染料转印图像记录材料,其中使用特定的银盐络合物作为银离子源,可在成像加热时获得,以切割提供染料的材料以提供对应于所述颜色的材料的成像图案中的可扩散染料 图像加热。 银盐络合物在提供增强的转印图像密度的系统中具有改善的溶解度。
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公开(公告)号:US09090541B2
公开(公告)日:2015-07-28
申请号:US13547870
申请日:2012-07-12
申请人: Peter Viski , Beena Bhatia , Tadeusz Warchol , David Messersmith
发明人: Peter Viski , Beena Bhatia , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , A61K31/64 , A61K31/695 , C07D213/56 , C07C237/26 , C07C275/30 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07D295/155 , C07F9/40
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号:US20110086822A1
公开(公告)日:2011-04-14
申请号:US12901196
申请日:2010-10-08
申请人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Y. Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Reddy Nagavelli , Paul Sheahan , Atul K. Verma , Peter Viski , Tadeusz Warchol
发明人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Y. Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Reddy Nagavelli , Paul Sheahan , Atul K. Verma , Peter Viski , Tadeusz Warchol
IPC分类号: A61K31/65 , C07C237/26 , C07D307/02 , C07D493/00 , C07D211/00 , C07D405/06 , C07D265/30 , A61P31/04
CPC分类号: C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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18.REDUCING CARBOHYDRATE DERIVATIVES OF ADAMANTANE AMINES, AND SYNTHESIS AND METHODS OF USE THEREOF 审中-公开
标题翻译: 降低青蒿琥酯的碳水化合物衍生物及其合成及其使用方法公开(公告)号:US20080300390A1
公开(公告)日:2008-12-04
申请号:US12144781
申请日:2008-06-24
申请人: Sebastian P. Assenza , Nanzhu Shen , Salvatore Iacono , Yuriy B. Kalyan , Peter Viski , Matthew Ronsheim
发明人: Sebastian P. Assenza , Nanzhu Shen , Salvatore Iacono , Yuriy B. Kalyan , Peter Viski , Matthew Ronsheim
IPC分类号: C07H15/24 , C07H5/06 , C07C211/61
CPC分类号: C07C211/38 , C07C2603/74 , C07H5/06 , C07H15/02 , C07H15/18
摘要: The present invention relates to reducing carbohydrate derivatives of adamantane amines of Formula A or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R1, R2, R3, and R4 are together or separately H, F, methyl or lower alkyl, alkenyl, or alkynyl groups, and Z is derived from a mono-, di-, oligo-, or poly-saccharide that originally had an aldehyde carbonyl group. The present invention also relates to processes for the preparation of such adamantane amine derivatives, and uses of such derivatives. The compounds of the present invention are useful in the treatment of infections caused by Gram positive or Gram negative bacteria.
摘要翻译: 本发明涉及还原式A的金刚烷胺或其药学上可接受的盐,溶剂合物或衍生物的碳水化合物衍生物,其中R 1,R 2,R 3和R 4一起或分别是H,F,甲基或低级烷基,烯基或炔基 基团,Z源自最初具有醛羰基的单糖,二糖,寡糖或多糖。 本发明还涉及制备这种金刚烷胺衍生物的方法,以及这些衍生物的用途。 本发明的化合物可用于治疗由革兰氏阳性或革兰氏阴性菌引起的感染。
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公开(公告)号:US07326696B2
公开(公告)日:2008-02-05
申请号:US10737361
申请日:2003-12-15
申请人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
CPC分类号: C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译: 讨论了氨基甲基取代的四环素化合物,药物组合物及其使用方法。
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公开(公告)号:US06846939B2
公开(公告)日:2005-01-25
申请号:US09895857
申请日:2001-06-29
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia
IPC分类号: C07D317/58 , A61K20060101 , A61K31/65 , A61P31/04 , C07C20060101 , C07C237/00 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C279/18 , C07C311/06 , C07C311/13 , C07C311/21 , C07C331/24 , C07C333/08 , C07C335/22 , C07C381/10 , C07D295/155 , C07D317/62 , C07F9/40 , C07C50/22 , C07C235/66
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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