-
公开(公告)号：US20130217138A1
公开(公告)日：2013-08-22
申请号：US13849938
申请日：2013-03-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Haar , Carina Horn
IPC: G01N33/66
CPC classification number: G01N33/66 , G01N21/6408 , G01N21/77 , G01N21/78 , G01N21/8483 , G01N33/525 , G01N2021/7786 , Y10T436/144444
Abstract: A test element for determining a body fluid is provided. The test element, in particular for determining the blood glucose level, includes a detection region which is charged with a reagent sensitive to the body fluid. A function element is arranged in or adjacent to the detection region for detecting at least one status parameter for the detection region, such that the functional element can be evaluated by means of a status measurement. A method for measuring the test element is also disclosed.
Abstract translation: 提供了一种用于确定体液的测试元件。 测试元件，特别是用于确定血糖水平的测试元件包括带有对体液敏感的试剂的检测区域。 功能元件布置在检测区域中或与检测区域相邻，用于检测用于检测区域的至少一个状态参数，使得可以通过状态测量来评估功能元件。 还公开了一种用于测量测试元件的方法。
-
公开(公告)号：US10180420B2
公开(公告)日：2019-01-15
申请号：US14963576
申请日：2015-12-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Klaus Andreas Bauer-Espindola , Carina Horn , Michael Marquant , Christine Nortmeyer , Volker Unkrig
Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.
-
13.发明申请公开(公告)号：US20180346886A1
公开(公告)日：2018-12-06
申请号：US16059096
申请日：2018-08-09
Inventor： Daniela Beck , Mara Boenitz-Dulat , Peter Kratzsch , Thomas Streidl , Carina Horn
Abstract: The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
-
公开(公告)号：US09594042B2
公开(公告)日：2017-03-14
申请号：US14136769
申请日：2013-12-20
Applicant: Roche Diagnostics Operations Inc.
Inventor： Liesel Doerge , Margarete Galm , Carina Horn
Abstract: Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal.
Abstract translation: 用于确定因子Xa抑制剂，特别是肝素和分级或低分子量肝素的方法和装置，以及血液样品中的直接因子Xa抑制剂。 所述方法包括使血液样品与含有至少一个凝血酶底物的检测试剂接触，所述凝血酶底物具有可被凝血酶切割的肽残基，并且经由羧基末端与电生物质酰胺结合，并且使用已知量的因子X试剂 和诱导因子X转化成因子Xa的活化剂。 随后，在第二步骤中，通过因子Xa介导的凝血酶活化和/或其时间过程将从凝血酶底物切割的电生物质的量或活性确定为使用电化学方法的测量信号。 在第三步骤中，基于该测量信号确定要分析的血液样品中的因子Xa抑制剂的量或与其相关的测量量，特别是与其相关的凝血时间。
-
公开(公告)号：US20230221311A1
公开(公告)日：2023-07-13
申请号：US18188549
申请日：2023-03-23
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Antje Baeumner , Franziska Beck , Carina Horn
IPC: G01N33/543 , G01N33/553 , B01L3/00 , G01N27/327 , G01N27/48
CPC classification number: G01N33/5438 , G01N33/553 , B01L3/502761 , G01N27/3277 , G01N27/3278 , G01N27/48 , B01L2300/0645 , B01L2200/0647
Abstract: A method for detecting at least one analyte by electrochemical detection, a working electrode of an analyte sensor and an analyte sensor for detecting at least one analyte in a sample by electrochemical detection. The method comprises contacting a fluid sample suspected to comprise the at least one analyte with the surface of an electrode comprising a binding agent capable of binding to the analyte; contacting the fluid sample with a detection agent comprising a further binding agent capable of binding to the analyte and a label, the label comprising a metal nanoparticle with a standard redox potential E° between 0 V and 1.2 V forming a detection complex on the surface of the electrode comprising the binding agent, the detection agent and the analyte precipitating at least a part of the label onto the electrode surface; and detecting the analyte by electrochemical detection.
-
Patent Agency Ranking
公开(公告)号：US11680924B2
公开(公告)日：2023-06-20
申请号：US16829788
申请日：2020-03-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Lambertson , Klaus Bauer-Espindola , Samuel Evgin , Carina Horn , Michael Marquant
IPC: G01N27/327
CPC classification number: G01N27/3273
Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.
-
公开(公告)号：US10704029B2
公开(公告)日：2020-07-07
申请号：US16059096
申请日：2018-08-09
Inventor： Daniela Beck , Mara Boenitz-Dulat , Peter Kratzsch , Thomas Streidl , Carina Horn
Abstract: The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
-
公开(公告)号：US09796746B2
公开(公告)日：2017-10-24
申请号：US14959280
申请日：2015-12-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Joachim Hoenes , Carina Horn , Thomas Meier , Wolfgang Petrich
IPC: C07H19/207 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/573 , G01N33/58 , C12Q1/26 , G01N21/64
CPC classification number: C07H19/207 , C12Q1/26 , G01N21/6428 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/5735 , G01N33/581 , G01N33/582 , G01N2201/062 , G01N2333/90248
Abstract: The invention also relates to compounds, which are useful for intra-molecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.
-
公开(公告)号：US20170191990A1
公开(公告)日：2017-07-06
申请号：US15438859
申请日：2015-08-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Peter Gebauer , Dieter Heindi , Carina Horn , Maksim Fomin
IPC: G01N33/52 , C07D241/42 , C07D403/06 , G01N33/50
CPC classification number: G01N33/52 , C07D241/40 , C07D241/42 , C07D401/06 , C07D403/06 , G01N33/5005
Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine- isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.
-
20.发明申请METHODS OF DETERMINING AN ANALYTE CONCENTRATION, AS WELL AS DEVICES AND TEST ELEMENTS INCORPORATING THE SAME 有权确定分析浓度的方法，以及作为设备和测试元素的方法公开(公告)号：US20140302541A1
公开(公告)日：2014-10-09
申请号：US14310438
申请日：2014-06-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Carina Horn , Volker Unkrig
IPC: C12Q1/54
CPC classification number: C12Q1/54 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1486 , A61B2562/0295 , G01N21/78 , G01N21/8483 , G01N33/525 , G01N2021/7786 , G01N2035/00108
Abstract: Methods, devices and test elements are disclosed for detecting at least one analyte in a sample. The methods, devices and test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The methods, devices and test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of a diffusable label.
Abstract translation: 公开了用于检测样品中至少一种分析物的方法，装置和测试元件。 方法，装置和测试元件用于检测一种或多种分析物，例如体液中的代谢物，特别是葡萄糖。 方法，装置和测试元件通过基于可扩散标签的扩散的校正因子来校正测试元件系统中的干扰变量，例如温度和/或血细胞比容。
-
-
-
-
-
-
-
-
-
Search Results
22
records
(took 0.021 seconds)
