公开(公告)号：US5600011A

公开(公告)日：1997-02-04

申请号：US474651

申请日：1995-06-07

Applicant: Shu Kobayashi

Inventor： Shu Kobayashi

IPC: B01J31/16 ,  B01J31/02 ,  C07B37/04 ,  C07B61/00 ,  C07C45/46 ,  C07C49/76 ,  C07C309/06 ,  C07F7/00 ,  B01J27/02 ,  B01J27/135

CPC classification number: B01J31/0227 ,  C07B37/04 ,  C07C309/06 ,  C07C45/46 ,  B01J2231/4205

Abstract: Disclosed are a novel hafnium compound represented by the formula Hf(OSO.sub.2 CF.sub.3).sub.4 and a process using a hafnium compound represented by the formula Hf(OSO.sub.2 CF.sub.3).sub.4 as a catalyst in a Friedel-Crafts reaction.

Abstract translation: 公开了由式Hf（OSO 2 CF 3）4表示的新型铪化合物，以及在Friedel-Crafts反应中使用由式Hf（OSO 2 CF 3）4表示的铪化合物作为催化剂的方法。

公开(公告)号：US08222177B2

公开(公告)日：2012-07-17

申请号：US12865053

申请日：2009-01-28

Applicant: Shu Kobayashi ,  Magno Agostinho ,  Uwe Schneider ,  Miyuki Yamaguchi

Inventor： Shu Kobayashi ,  Magno Agostinho ,  Uwe Schneider ,  Miyuki Yamaguchi

IPC: B01J31/16 ,  C07C311/15

CPC classification number: C07C311/16 ,  B01J31/0212 ,  B01J31/1805 ,  B01J2231/348 ,  B01J2531/21 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/24 ,  B01J2531/25 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/347 ,  C07C201/12 ,  C07C2602/10 ,  C07D207/325 ,  C07D307/54 ,  C07D333/24 ,  C07C69/738 ,  C07C205/56

Abstract: Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed of MX2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R7, R8, R9 and R10 each represents a substituted cyclic group or an unsubstituted cyclic group.]

Abstract translation: 公开了一种能够实现不需要大量丙二酸酯的有效的不对称迈克尔加成反应的技术，同时反应时间短。 具体公开的是由MX2（其中M为Be，Mg，Ca，Sr，Ba或Ra，X为任意基团）和通式[I]表示的化合物组成的催化剂。 [式中，R 7，R 8，R 9，R 10分别表示取代的环状基团或未取代的环状基团。

公开(公告)号：US20110071310A1

公开(公告)日：2011-03-24

申请号：US12922008

申请日：2009-02-27

Applicant: Shu Kobayashi ,  Yasuhiro Yamashita ,  Kazutaka Seki

Inventor： Shu Kobayashi ,  Yasuhiro Yamashita ,  Kazutaka Seki

IPC: C07C229/00 ,  C07F9/28

CPC classification number: C07F9/4056 ,  B01J31/0222 ,  B01J31/0237 ,  B01J31/0251 ,  B01J31/0271 ,  B01J31/1805 ,  B01J2231/346 ,  B01J2531/20 ,  B01J2531/21 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/24 ,  B01J2531/25 ,  C07B53/00 ,  C07B2200/07 ,  C07C251/24 ,  C07C271/22 ,  C07C2601/14 ,  C07C2603/18 ,  C07D307/52 ,  C07F9/4006 ,  C07F9/65515 ,  C07F9/655345

Abstract: Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives). Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.

Abstract translation: 提供了合成二氨基酸（二氨基酸衍生物）的有效技术。 公开了通式[II]或[IV]表示的二氨基酸衍生物原料的芴基被除去的二氨基酸衍生物的制造方法。

公开(公告)号：US07741242B2

公开(公告)日：2010-06-22

申请号：US10527699

申请日：2003-09-01

Applicant: Shu Kobayashi ,  Atsunori Sano ,  Keiji Oono

Inventor： Shu Kobayashi ,  Atsunori Sano ,  Keiji Oono

IPC: B01J23/44 ,  B01J37/00

CPC classification number: B01J31/06 ,  B01J2231/44 ,  B01J2231/645 ,  B01J2231/70 ,  C07B2200/11 ,  C07C17/16 ,  C07C41/16 ,  C07C45/29 ,  C07C45/62 ,  C07C67/343 ,  C07D303/16 ,  C07F15/006 ,  C07F15/0066 ,  C07C22/04 ,  C07C47/232 ,  C07C49/213 ,  C07C69/618 ,  C07C43/215

Abstract: The present invention discloses 1) a catalyst composition consisting of a crosslinked organic polymer compound and a palladium catalyst, wherein said catalyst is physically carried on said crosslinked organic polymer compound, 2) a manufacturing method of the above catalyst composition 1), characterized by homogenizing a straight chain organic polymer compound, having a crosslinkable functional group, and a palladium catalyst in a solvent dissolving said straight chain organic polymer compound, then depositing a composition thus formed and subjecting the crosslinkable functional group in said deposit to a crosslinking reaction, 3) a method for substitution reaction at an allyl position, characterized by reacting an allyl carbonate and a neucleophilic agent in the presence of the above catalyst composition 1), and 4) a method for oxidizing an alcohol, characterized by subjecting the above catalyst composition 1) to reaction with an alcohol.

Abstract translation: 本发明公开了1）由交联的有机高分子化合物和钯催化剂组成的催化剂组合物，其中所述催化剂物理地携带在所述交联的有机高分子化合物上，2）上述催化剂组合物1）的制备方法，其特征在于均化 具有可交联官能团的直链有机高分子化合物和溶解所述直链有机高分子化合物的溶剂中的钯催化剂，然后沉积由此形成的组合物，并对所述沉积物中的可交联官能团进行交联反应; 3） 在烯丙基位置进行取代反应的方法，其特征在于在上述催化剂组合物1）的存在下使碳酸烯丙酯和亲核试剂反应，和4）一种氧化醇的方法，其特征在于将上述催化剂组合物1） 与酒精反应。

公开(公告)号：US07705161B2

公开(公告)日：2010-04-27

申请号：US10592139

申请日：2005-02-21

Applicant: Shu Kobayashi ,  Yasuhiro Yamashita

Inventor： Shu Kobayashi ,  Yasuhiro Yamashita

IPC: C07D231/06

CPC classification number: C07B53/00 ,  C07D231/04 ,  C07D231/06 ,  C07D401/06

Abstract: A method of the intramolecular and intermolecular cyclization of an N-acylhydrazone for obtaining a pyrazoline skeleton or pyrazolidine skeleton under ordinary conditions with high stereoselectivity and in high yield. An N-acylhydrazone represented by the following formula (I): (wherein R1 and R2 are the same or different and each represents hydrogen or a hydrocarbon group and Ar represents an optionally substituted aromatic hydrocarbon group) is converted to an N-acylpyrazoline derivative with high stereoselectivity in the presence of a Lewis acid catalyst or asymmetric Lewis acid catalyst.

Abstract translation: 用于获得吡唑啉骨架或吡唑烷骨架的N-酰腙的分子内和分子间环化的方法，在具有高立体选择性和高收率的常规条件下。 由下式（I）表示的N-酰腙：（其中R 1和R 2相同或不同，各自表示氢或烃基，Ar表示任选取代的芳族烃基）转化成N-酰基吡唑啉衍生物， 在路易斯酸催化剂或不对称路易斯酸催化剂存在下具有高立体选择性。

公开(公告)号：US20090143607A1

公开(公告)日：2009-06-04

申请号：US12224636

申请日：2007-02-27

Applicant: Shu Kobayashi ,  Hidekazu Oyamada ,  Ryo Akiyama ,  Takeshi Naito

Inventor： Shu Kobayashi ,  Hidekazu Oyamada ,  Ryo Akiyama ,  Takeshi Naito

IPC: B01J31/06 ,  C07C69/52 ,  C07F7/02

CPC classification number: C07C67/303 ,  B01J23/40 ,  B01J23/70 ,  B01J31/124 ,  B01J31/127 ,  B01J31/165 ,  B01J31/26 ,  B01J31/28 ,  B01J35/006 ,  B01J37/0219 ,  B01J2231/4261 ,  B01J2231/641 ,  B01J2531/824 ,  B01J2531/828 ,  C07B2200/11 ,  C07C2/861 ,  C07C5/03 ,  C07C5/08 ,  C07C67/343 ,  C07C205/19 ,  C07C2523/42 ,  C07C2523/44 ,  C07C2523/72 ,  C07F15/0066 ,  C07F15/0086 ,  C07F15/0093 ,  C07C15/54 ,  C07C15/18 ,  C07C69/612 ,  C07C69/618

Abstract: The present invention provides a polysilane-supported transition metal catalysts or a polysilane/inorganic compound-supported transition metal catalysts, wherein various types of transition metals are supported by polysilane compounds, or combination of polysilanes and inorganic compounds. The catalysts of the present invention are hardly soluble in hydrocarbons and alcohols and are useful as catalysts in heterogeneous system for various organic synthetic reactions using the above solvents. Polysilanes supporting transition metals are easily crosslinkable by thermal treatment, microwave irradiation, UV irradiation or chemical methods such as hydrosilylation reaction and are changed to be insoluble in various solvents keeping high catalytic activity. Moreover, the stability and operability of polysilane-supported transition metal catalysts will be improved by the support thereof on inorganic compounds. These polysilane-supported transition metal catalysts show a high catalytic activity in hydrogenation reaction, hydrosilylation reaction, Heck reaction, Suzuki-Miyaura coupling reactions and the like. The catalyst is easily recoverable and reusable and the leakage of metals is extremely few.

Abstract translation: 本发明提供一种聚硅烷负载的过渡金属催化剂或聚硅烷/无机化合物负载的过渡金属催化剂，其中各种类型的过渡金属由聚硅烷化合物或聚硅烷和无机化合物的组合负载。 本发明的催化剂几乎不溶于烃和醇，并且可用作用于使用上述溶剂的各种有机合成反应的异相体系中的催化剂。 支撑过渡金属的聚硅烷通过热处理，微波照射，UV照射或氢化硅烷化反应等化学方法易于交联，并且改变为不溶于保持高催化活性的各种溶剂。 此外，通过其对无机化合物的支持，聚硅烷负载的过渡金属催化剂的稳定性和可操作性将得到改善。 这些聚硅烷负载的过渡金属催化剂在氢化反应，氢化硅烷化反应，Heck反应，Suzuki-Miyaura偶联反应等中显示出高的催化活性。 催化剂易于回收和再利用，金属的泄漏极少。

公开(公告)号：US07323603B2

公开(公告)日：2008-01-29

申请号：US10471693

申请日：2002-03-08

Applicant: Shu Kobayashi ,  Kei Manabe

Inventor： Shu Kobayashi ,  Kei Manabe

IPC: C07C45/00

CPC classification number: C07C45/511

Abstract: A method for aldol reaction in water, which comprises: reacting an aldehyde with a silyl enol ether in an aqueous medium in the presence of a boronic acid represented by the following general formula (1): R1R2BOH  (1) (wherein R1 and R2 are the same or different hydrocarbon groups that may contain a substituent), a surfactant, and a Brønsted acid is provided. This method for aldol reaction in water uses a catalytic amount of the boron source to give products in high yield and selectivity.

Abstract translation: 一种在水中醛醇醛反应的方法，其包括：在下列通式（1）表示的硼酸存在下，在水性介质中使醛与甲硅烷基烯醇醚反应：<？在线式描述=“ 在线公式“end =”lead“？> R＆lt; 1＆lt; 2＆gt; BOH（1）<？in-line-formula description =”In-line Formulas“end =“尾”→（其中R 1和R 2是相同或不同的可以含有取代基的烃基），表面活性剂和布朗斯台德酸 。 这种在水中醛醇反应的方法使用催化量的硼源，以高产率和选择性产生产物。

公开(公告)号：US20070265472A1

公开(公告)日：2007-11-15

申请号：US10589259

申请日：2005-03-09

Applicant: Shu Kobayashi ,  Haruro Ishitani ,  Yasuhiro Yamashita

Inventor： Shu Kobayashi ,  Haruro Ishitani ,  Yasuhiro Yamashita

IPC: B01J31/26 ,  C07B53/00 ,  C07B61/00 ,  C07C15/42 ,  C07C213/04

CPC classification number: B01J31/223 ,  B01J2231/341 ,  B01J2231/485 ,  B01J2531/0266 ,  B01J2531/57 ,  C07B53/00 ,  C07C221/00 ,  C07C327/22 ,  C07D307/54 ,  C07D333/24 ,  C07C225/06

Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons).

Abstract translation: 通过混合具有R或S构型的联萘酚结构的五价铌化合物和光学活性三醇或四醇，得到不对称反应催化剂，三醇由下式表示：（其中，Y为二价烃，R ^{1是氢原子，卤素原子，三氟甲基或具有至多4个碳原子的烷基或烷氧基）。}

公开(公告)号：US20070238902A1

公开(公告)日：2007-10-11

申请号：US11587430

申请日：2005-02-14

Applicant: Shu Kobayashi ,  Kei Manabe

Inventor： Shu Kobayashi ,  Kei Manabe

IPC: C07C45/72 ,  C07B61/00 ,  C07C49/747 ,  C07C49/835 ,  C07C49/84 ,  C07C49/83 ,  C07C327/22

CPC classification number: C07C327/22 ,  C07C45/511 ,  C07C49/83 ,  C07C49/84 ,  C07C49/747

Abstract: An aldol reaction in an aqueous solution between an aldehyde represented by the following formula (I): R—CHO  (I) (wherein R is a hydrocarbon group which may have an substituent), and a silicon enolate represented by the following formula (II): (wherein R1 and R2 are a hydrogen atom or an aliphatic hydrocarbon group, at least one of them being an aliphatic hydrocarbon group; and R3 is a substituent selected from the group consisting of an aliphatic hydrocarbon group, an aromatic hydrocarbon group and a sulfur-containing substituent, wherein R2 and R3 may be combined with each other to form a ring) is performed so as to generate diastereoselectivity by using FeCl3, which is a low-cost Lewis acid, and a surfactant.

Abstract translation: 在由下式（I）表示的醛之间的水溶液中的醛醇缩合反应：<？in-line-formula description =“In-line formula”end =“lead”→R-CHO（I）<αin -line-formula description =“In-line Formulas”end =“tail”？>（其中R是可以具有取代基的烃基）和由下式（II）表示的硅烯醇酯：（其中R < SUP> 1和R 2是氢原子或脂族烃基，其中至少一个是脂族烃基; R 3是 选自脂族烃基，芳族烃基和含硫取代基的取代基，其中R 2和R 3可以彼此结合成 形成环），以便通过使用作为低成本路易斯酸的FeCl 3 N和表面活性剂来产生非对映选择性。

公开(公告)号：US20070191624A1

公开(公告)日：2007-08-16

申请号：US10591829

申请日：2005-03-08

Applicant: Shu Kobayashi ,  Ryo Akiyama ,  Nobuyuki Kawai ,  Masahiro Takeuchi

Inventor： Shu Kobayashi ,  Ryo Akiyama ,  Nobuyuki Kawai ,  Masahiro Takeuchi

IPC: C07C253/10 ,  C07C209/20 ,  B01J31/00

CPC classification number: C07C67/347 ,  B01J13/14 ,  B01J31/165 ,  B01J31/2239 ,  B01J31/226 ,  B01J31/4015 ,  B01J2231/326 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/35 ,  B01J2531/37 ,  B01J2531/38 ,  B01J2531/842 ,  B01J2540/22 ,  C07C45/46 ,  C07C45/511 ,  C07C45/72 ,  C07C45/73 ,  C07C49/245 ,  C07C49/573 ,  C07C49/76 ,  C07C49/83 ,  C07C67/00 ,  C07C227/12 ,  C07C327/22 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  Y02P20/584 ,  C07C69/732 ,  C07C69/738 ,  C07C69/757 ,  C07C229/34

Abstract: The objective is to incarcerate a Lewis acid metal in a polymer and to make this catalyst recoverable while maintaining its function as a Lewis acid metal catalyst. The present invention is a polymer-incarcerated Lewis acid metal catalyst in which a Lewis acid metal is incarcerated in a crosslinked polymer and the crosslinked polymer is crosslinked using the crosslinking groups contained in a crosslinkable polymer. The polymer incarcerated Lewis acid metal catalyst is characterized by the crosslinkable polymer containing at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups, and the hydrophobic substituents contain aromatic substituents. This crosslinkable polymer preferably comprises at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups and a monomer unit containing hydrophobic substituents. This catalyst can be obtained by subjecting a polymer micelle incarcerated Lewis acid metal obtained by mixing an organic solution containing a crosslinkable polymer and a Lewis acid metal with a bad solvent to a crosslinking reaction. This catalyst is useful as a catalyst in aldol reactions, cyanolation reactions, allylation reactions, Michael reactions, Mannich reactions, Diels Alder reactions and Friedel Crafts reactions.

Abstract translation: 目的是监测聚合物中的路易斯酸金属，并使该催化剂可恢复，同时保持其作为路易斯酸金属催化剂的功能。 本发明是一种聚合物 - 监控的路易斯酸金属催化剂，其中路易斯酸金属在交联聚合物中被监控，交联聚合物使用可交联聚合物中所含的交联基团进行交联。 聚合物监控的路易斯酸金属催化剂的特征在于含有至少一种含有疏水取代基的单体单元和含有交联基团的亲​​水取代基的交联聚合物，疏水性取代基含有芳族取代基。 该可交联聚合物优选包含至少一种含有疏水取代基的单体单元和含有交联基团的亲​​水取代基和含有疏水取代基的单体单元。 该催化剂可以通过将通过将含有可交联聚合物的有机溶液和路易斯酸金属得到的聚合物胶束监控的路易斯酸金属与不良溶剂进行交联反应来获得。 该催化剂可用作醛醇反应，硅烷醇化反应，烯丙基化反应，迈克尔反应，曼尼希反应，狄尔斯阿尔德反应和Friedel Crafts反应中的催化剂。