公开(公告)号：US11099401B2

公开(公告)日：2021-08-24

申请号：US16443519

申请日：2019-06-17

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Jonathan D. Olson ,  Keith D. Paulsen ,  David W. Roberts

IPC: G02B27/28 ,  G02B5/20 ,  H04N5/225 ,  H04N5/33 ,  G02B27/42

Abstract: A birefringent spectral demultiplexer for hyperspectral imaging includes N birefringent beamsplitting stages arranged along a light propagation path, to produce 2N mutually divergent output light beams. Each of the output light beams differs from every other one of the output light beams in polarization and/or spectral bandwidth. Each birefringent beamsplitting stage includes a retarder for modifying polarization of each light beam received by the birefringent beamsplitting stage, and a Wollaston prism for splitting each light beam into two orthogonally polarized and divergent light beams. The Wollaston prism has a beamsplitting interface arranged at an oblique angle to the light propagation path. The oblique angle of the beamsplitting interface of each Wollaston prism of the series, except for the first one, is smaller than the oblique angle of the beamsplitting interface of each preceding Wollaston prism. The demultiplexer may be configured to accept input light of any polarization.

公开(公告)号：US11937951B2

公开(公告)日：2024-03-26

申请号：US18159495

申请日：2023-01-25

Applicant: The Trustees of Dartmouth College

Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

IPC: A61B5/00 ,  A61K49/00

CPC classification number: A61B5/7278 ,  A61B5/0071 ,  A61K49/0058 ,  A61B5/0035 ,  A61B5/0062 ,  A61B2576/00

Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

公开(公告)号：US20230280577A1

公开(公告)日：2023-09-07

申请号：US18144767

申请日：2023-05-08

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

IPC: G02B21/06 ,  G02B21/36 ,  A61B1/06

CPC classification number: G02B21/06 ,  G02B21/36 ,  A61B1/063

Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

公开(公告)号：US20230233157A1

公开(公告)日：2023-07-27

申请号：US18159495

申请日：2023-01-25

Applicant: The Trustees of Dartmouth College

Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

IPC: A61B5/00 ,  A61K49/00

CPC classification number: A61B5/7278 ,  A61B5/0071 ,  A61K49/0058 ,  A61B5/0062 ,  A61B5/0035 ,  A61B2576/00

Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

公开(公告)号：US20230020195A1

公开(公告)日：2023-01-19

申请号：US17948434

申请日：2022-09-20

Applicant: The Trustees of Dartmouth College

Inventor： Stephen Chad Kanick ,  Brian William Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III ,  Venkataramanan Krishnaswamy

IPC: A61B5/00

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

公开(公告)号：US10667870B2

公开(公告)日：2020-06-02

申请号：US15735907

申请日：2016-06-10

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Venkataramanan Krishnaswamy ,  Richard J. Barth, Jr. ,  Keith D. Paulsen

IPC: G06K9/00 ,  A61B34/20 ,  A61B17/34 ,  A61B17/00

Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

公开(公告)号：US09792411B2

公开(公告)日：2017-10-17

申请号：US13831160

申请日：2013-03-14

Applicant: The Trustees of Dartmouth College

Inventor： Adam J. Pattison ,  Matthew D J McGarry ,  Keith D. Paulsen ,  John B. Weaver

IPC: A61B5/103 ,  A61B5/117 ,  G06F19/00 ,  G01N3/32 ,  A61B5/00 ,  A61B5/055 ,  G01R33/563 ,  A61B5/11

CPC classification number: G06F19/3437 ,  A61B5/0051 ,  A61B5/055 ,  A61B5/1128 ,  A61B5/4064 ,  A61B5/6868 ,  G01N3/32 ,  G01N2203/0005 ,  G01N2203/0069 ,  G01N2203/0073 ,  G01N2203/0094 ,  G01N2203/0218 ,  G01R33/56358 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

Abstract: A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a displacement to tissue at a particular frequency selected from a range of frequencies, and the force monitor adapted to monitor a mechanical response of tissue. The system also has a processor coupled to drive the actuator and to read the mechanical response, the processor coupled to execute from memory a poroelastic model of mechanical properties of the material, and a convergence procedure for determining parameters for the poroelastic model such that the model predicts mechanical response of the tissue to within limits.

公开(公告)号：US20170164836A1

公开(公告)日：2017-06-15

申请号：US15116808

申请日：2015-02-04

Applicant: The Trustees of Dartmouth College

Inventor： Venkataramanan Krishnaswamy ,  Brian W. Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III

IPC: A61B5/00 ,  G01B11/25

CPC classification number: A61B5/0059 ,  A61B5/0075 ,  A61B5/4869 ,  A61B2505/05 ,  G01B11/2513

Abstract: A structured-light imaging system includes a structured light projector for illuminating a surface and an electronic camera configured to image the surface. An image processor receives the images and has structured light scatteroscopy (SLS) firmware with machine readable instructions that illuminate the surface with structured light having a spatial frequency of at least 0.5 mm″1, and process the images to determine a map of scattering parameters at the surface independent of absorption properties. In an embodiment, the system also has cameras configured to obtain a stereo pair of images of the surface, the image processor having 3D firmware for extracting a three dimensional model of the surface from the stereo pair of images and compensating the map for non-flat surfaces.

公开(公告)号：US20160278678A1

公开(公告)日：2016-09-29

申请号：US15044097

申请日：2016-02-15

Applicant: The Trustees of Dartmouth College

Inventor： Pablo Valdes ,  Frederic Leblone ,  Keith D. Paulsen ,  Brian Campbell Wilson ,  David W. Roberts ,  Michael Jermyn

IPC: A61B5/1455 ,  A61B5/00 ,  A61B1/04 ,  A61B5/055 ,  A61B5/1495 ,  A61B1/06 ,  A61B1/00 ,  A61B5/1459 ,  A61B5/145

CPC classification number: A61B5/14556 ,  A61B1/00009 ,  A61B1/00165 ,  A61B1/00193 ,  A61B1/042 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  A61B1/07 ,  A61B1/3132 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/055 ,  A61B5/14546 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/4836 ,  A61B5/7264 ,  G01J3/0229 ,  G01J3/1256 ,  G01J3/2823 ,  G01J2003/1269 ,  G01J2003/2826

Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.

Abstract translation: 诸如手术显微镜，腹腔镜或内窥镜或与这些装置集成的成像系统包括提供图案化的白光和/或荧光激发光的照明器。 在使用高光谱成像阵列的实施例中，系统接收并高光图像光，并且/或使用窄带可调滤波器将滤波的接收光传递到成像器。 实施例可以从立体图像构造3-D表面模型，并且将使用在图案化光线中拍摄的图像或使用从白光曝光获得的其它近似来估计目标的光学性质。 在激发光下拍摄的高光谱图像显示为荧光图像，并对组织的光学性质进行校正，以提供荧光团浓度的定量图谱。 处理来自高光谱图像的光谱信息，以提供组织表面下方的荧光团的深度。 还准备了深度荧光的定量图像。 图像显示给外科医生用于手术。

公开(公告)号：US12285277B2

公开(公告)日：2025-04-29

申请号：US18614944

申请日：2024-03-25

Applicant: The Trustees of Dartmouth College

Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

IPC: A61B5/00 ,  A61K49/00

Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.