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    Flame ionization detection for supercritical fluid chromatography employing a matched separation column and flame burner
    16.
    发明授权
    Flame ionization detection for supercritical fluid chromatography employing a matched separation column and flame burner 有权

    公开(公告)号：US09664654B2

    公开(公告)日：2017-05-30

    申请号：US14675865

    申请日：2015-04-01

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

    IPC: G01N30/68

    CPC classification number: G01N30/68

    Abstract: The present disclosure relates to flame based detection methods for compressed mobile phase chromatography. In particular, the present disclosure relates to the operation of a flame ionization detector for carbon dioxide based chromatography, such as supercritical fluid chromatography. The present disclosure includes a method of matching a chromatographic column with a flame ionization detector inner burner including providing a chromatographic column with an internal diameter, determining an optimal mobile phase flow rate for the chromatographic column, calculating an optimal inner diameter of the inner burner that combined with the internal diameter and flow rate of the column produces optimal detector performance, and providing a flame ionization detector inner burner having an inner diameter substantially equal to the calculated optimal inner diameter.

    THERMALLY MODULATED VARIABLE RESTRICTOR
    18.
    发明申请
    THERMALLY MODULATED VARIABLE RESTRICTOR 审中-公开
    热调制变量限制器

    公开(公告)号：US20160018366A1

    公开(公告)日：2016-01-21

    申请号：US14773780

    申请日：2014-01-27

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

    IPC: G01N30/30 ,  G01N30/32

    CPC classification number: G01N30/30 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N30/6004 ,  G01N2030/3038 ,  G01N2030/324 ,  G01N2030/6008

    Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.

    Abstract translation: 色谱系统中使用的热调制可变限制器可独立控制通过色谱柱的可压缩流动相的系统压力和线速度。 限流器包括具有流体通道的限流器主体，其具有从柱接收流动相的入口和流动相离开流体通道的出口。 设置在流体通道出口附近的限制器尖端具有小于流体通道的内径的出口开口。 热连接到流体通道在其入口和出口之间的子部分的加热元件加热通过流体通道的该部分的流动相。 限制器尖端响应于流动相的加热而产生的限制使得能够独立地控制柱内的流动相的系统压力和线性速度。

    TECHNIQUES FOR PERFORMING MASS SPECTROMETRY
    19.
    发明申请
    TECHNIQUES FOR PERFORMING MASS SPECTROMETRY 审中-公开
    执行质谱分析的技术

    公开(公告)号：US20150206733A1

    公开(公告)日：2015-07-23

    申请号：US14425124

    申请日：2013-09-06

    Applicant: Waters Technologies Corporation

    Inventor： James P. Murphy

    IPC: H01J49/26 ,  B01D59/44

    CPC classification number: H01J49/26 ,  B01D59/44 ,  H01J49/428

    Abstract: Techniques are described for performing mass spectrometry. A quadrupole, or more generally, an electrode-based device, performs mass filtering for selectively filtering ions. One or more components generate a first RF potential, a DC potential, and a supplemental RF potential applied to the quadrupole. The supplemental RF potential has a corresponding multiple notched waveform having a plurality of corresponding frequencies thereby allowing a plurality of ions to pass through the quadrupole at a same time. Each of the plurality of corresponding frequencies corresponds to a notch in the waveform allowing one of the plurality of ions of a different mass or m/z to pass through the quadrupole for processing by another component or device.

    Abstract translation: 描述了进行质谱分析的技术。 四极或更一般地，基于电极的装置进行用于选择性过滤离子的质量过滤。 一个或多个组件产生施加到四极杆的第一RF电位，DC电势和补充RF电位。 补充RF电位具有对应的多个具有多个相应频率的多个缺口波形，从而允许多个离子同时穿过四极杆。 多个对应频率中的每一个对应于波形中的凹口，允许不同质量或m / z的多个离子中的一个离子通过四极以供另一个组件或装置处理。

    SYSTEMS, DEVICES, AND METHODS FOR CONNECTING A CHROMATOGRAPHY SYSTEM TO A MASS SPECTROMETER
    20.
    发明申请
    SYSTEMS, DEVICES, AND METHODS FOR CONNECTING A CHROMATOGRAPHY SYSTEM TO A MASS SPECTROMETER 审中-公开
    用于将色谱系统连接到质谱仪的系统，设备和方法

    公开(公告)号：US20150144782A1

    公开(公告)日：2015-05-28

    申请号：US14552872

    申请日：2014-11-25

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff C. Gerhardt

    IPC: H01J49/10 ,  H01J49/00 ,  H01J49/26 ,  H01J49/04

    CPC classification number: H01J49/10 ,  H01J49/0431 ,  Y10T29/5313

    Abstract: The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer. The ion source includes a first conduit for receiving eluent from the chromatography device, a heater for heating at least a portion of said first conduit, a second conduit in fluid communication with the first conduit, an inlet for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume.

    Abstract translation: 本发明提供分析仪器之间的界面，例如在色谱系统和质谱仪之间。 在一个示例性实施例中，提供离子源用于将基于二氧化碳的色谱装置连接到质谱仪。 离子源包括用于从色谱装置接收洗脱液的第一管道，用于加热所述第一管道的至少一部分的加热器，与第一管道流体连通的第二管道，用于从所述第二管道接收洗脱液并引入 所述洗脱液进入离子源区域以在所述离子源区域中形成气体和/或液体的羽流;以及电离促进入口，用于将离子化促进流体注入到所述离子源区域中以与所述羽流相互作用以促进至少 一些羽流。

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