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    Atmospheric Interface for Electrically Grounded Electrospray
    12.
    发明申请
    Atmospheric Interface for Electrically Grounded Electrospray 审中-公开
    电接地电喷雾的大气界面

    公开(公告)号：US20160307744A1

    公开(公告)日：2016-10-20

    申请号：US15102910

    申请日：2014-12-22

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Joseph A. Jarrell

    IPC: H01J49/04 ,  H01J49/16

    CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165

    Abstract: An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.

    Abstract translation: 提供了用于质谱仪系统的界面。 界面可以包括由第一陶瓷材料制成的内陶瓷管和由围绕内陶瓷管的第二陶瓷材料制成的外管。 内部陶瓷管可以具有高电阻率和高导热性，并且中间陶瓷管可以具有比第一陶瓷材料的电阻率高至少一个数量级的电阻率和至少为 数量级高于第一陶瓷材料的热导率。

    Measuring Fluid Density
    14.
    发明申请
    Measuring Fluid Density 审中-公开
    测量流体密度

    公开(公告)号：US20130333467A1

    公开(公告)日：2013-12-19

    申请号：US13908261

    申请日：2013-06-03

    Applicant: Waters Technologies Corporation

    Inventor： Joseph A. Jarrell

    IPC: G01N9/32

    CPC classification number: G01N9/32 ,  G01N9/002 ,  G01N30/00 ,  G01N30/28

    Abstract: An apparatus includes a vibration element defining a fluidic passageway; an excitation element for exciting vibration of the vibration element; a detector for providing a signal representative of the frequency excited; and control electronics configured to determine a density of a fluid flowing through the fluidic passageway based, at least in part, on the signal provided by the detector. The vibration element is configured such that Coriolis force induced twisting of the vibration element is substantially inhibited.

    Abstract translation: 一种装置包括限定流体通道的振动元件; 用于激励振动元件的振动的激励元件; 用于提供代表激发频率的信号的检测器; 以及控制电子器件，其被配置为至少部分地基于由检测器提供的信号来确定流过流体通道的流体的密度。 振动元件被构造成使得科里奥利力引起的振动元件的扭转被基本上抑制。

    PURGE METHOD FOR LOW PRESSURE GRADIENT FORMATION LIQUID CHROMATOGRAPHY
    17.
    发明申请
    PURGE METHOD FOR LOW PRESSURE GRADIENT FORMATION LIQUID CHROMATOGRAPHY 审中-公开
    低压梯度形成液相色谱法的方法

    公开(公告)号：US20150336026A1

    公开(公告)日：2015-11-26

    申请号：US14696572

    申请日：2015-04-27

    Applicant: Waters Technologies Corporation

    Inventor： Neal B. Almeida ,  Christopher Seith ,  Michael R. Jackson ,  John Angelosanto ,  Joseph A. Jarrell

    IPC: B01D15/18 ,  G01N30/26

    CPC classification number: B01D15/18 ,  G01N30/26 ,  G01N30/34 ,  Y10T137/0424 ,  Y10T137/4259

    Abstract: Described is a method for purging a fluid channel is a low pressure gradient formation liquid flow system. Control of the fluid channels for multiple solvents allows for one or more static volumes of solvents not intended for use in an isocratic flow to be purged from their fluid channels to avoid contamination of the isocratic solvent. Advantageously, the method avoids the need to modify equipment or to reconfigure a pumping system so that the inlet is directly coupled to a single solvent source. Thus there is no need to bypass existing valves and liquid coupling components where solvents are combined during conventional gradient operation.

    Abstract translation: 描述了一种清洗流体通道的方法是低压梯度形成液体流动系统。 用于多种溶剂的流体通道的控制允许一个或多个静态体积的溶剂不用于从其流体通道中清除等度流，以避免污染等度溶剂。 有利地，该方法避免了修改设备或重新配置泵送系统的需要，使得入口直接耦合到单个溶剂源。 因此，在常规梯度操作期间，不需要绕过现有的阀和液体耦合部件，其中溶剂被组合。

    MOBILE PHASE SOLVENT DELIVERY MODULE
    18.
    发明申请
    MOBILE PHASE SOLVENT DELIVERY MODULE 审中-公开
    移动相溶剂输送模块

    公开(公告)号：US20130134079A1

    公开(公告)日：2013-05-30

    申请号：US13677695

    申请日：2012-11-15

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Joseph A. Jarrell ,  Pamela C. Iraneta ,  Douglas P. Wittmer

    IPC: B01D15/14

    CPC classification number: B01D15/14 ,  G01N30/30 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/8881 ,  G01N2030/342 ,  B01D15/40

    Abstract: Described is a mobile phase solvent delivery module for liquid chromatography and supercritical fluid chromatography systems. The module includes a pump disposed in a fluid path that conducts a mobile phase solvent. The pump provides the mobile phase solvent at an increased pressure. The module also includes a purification cartridge disposed in the fluid path either before or after the pump. The purification cartridge has an inlet to receive the mobile phase solvent and an outlet to provide a purified mobile phase solvent, and includes a packing material for removing an impurity from the mobile phase solvent. In various embodiments, the module also includes one or more additional components to allow various techniques for regeneration or replacement of spent purification cartridges. For example, the module may also include one or more of a temperature control module, a fluidic switch and one or more additional purification cartridges.

    Abstract translation: 描述了用于液相色谱和超临界流体色谱系统的流动相溶剂递送模块。 模块包括设置在流动路径中的泵，其传导流动相溶剂。 该泵在增加的压力下提供流动相溶剂。 该模块还包括在泵之前或之后设置在流体路径中的净化筒。 净化筒具有容纳流动相溶剂的入口和出口以提供纯化的流动相溶剂，并且包括用于从流动相溶剂中除去杂质的填充材料。 在各种实施例中，模块还包括一个或多个附加部件，以允许用于再生或更换废净化筒的各种技术。 例如，模块还可以包括温度控制模块，流体开关和一个或多个附加的净化盒中的一个或多个。

    CHARGED AEROSOL DETECTORS
    19.
    发明公开
    CHARGED AEROSOL DETECTORS 审中-公开

    公开(公告)号：US20240345037A1

    公开(公告)日：2024-10-17

    申请号：US18634339

    申请日：2024-04-12

    Applicant: Waters Technologies Corporation

    Inventor： Joseph A. Jarrell

    IPC: G01N30/12 ,  G01N30/02 ,  G01N30/38 ,  G01N30/72 ,  G01N30/74

    CPC classification number: G01N30/12 ,  G01N30/38 ,  G01N30/7233 ,  G01N30/74 ,  G01N2030/027 ,  G01N2030/743

    Abstract: Embodiments described herein relate to improved devices and techniques for measuring the charge carried by analyte particles. The charge may be measured in a way that does not destroy the analyte, so that the analyte remains available for further analysis. The charged analyte particles may pass through (or by) an electrode. In doing so, they induce a counter charge on that electrode which can be detected electronically. Subsequent to their passage through that electrode, the particles can be collected on a substrate or may pass in real-time into a mass spectrometer. In some embodiments, both conventional destructive detection and nondestructive detection may both be present in an improved charged aerosol detector and the stream of charged particles may be directed to one or the other by a suitable redirector. Embodiments may be combined with light scattering analysis to provide further non-destructive analysis. Various combinations of these improvements are also described.

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