公开(公告)号：US08313651B2

公开(公告)日：2012-11-20

申请号：US13169420

申请日：2011-06-27

Applicant: Ronald F. Childs ,  Elena N. Komkova ,  Donna Lisa Crossley ,  Alicja M. Mika

Inventor： Ronald F. Childs ,  Elena N. Komkova ,  Donna Lisa Crossley ,  Alicja M. Mika

IPC: B01D61/14 ,  B01D71/28 ,  B01D63/10 ,  B01D63/08 ,  B01D69/00 ,  B01D61/00 ,  B01D71/00

CPC classification number: B01D69/10 ,  B01D63/06 ,  B01D63/061 ,  B01D63/081 ,  B01D63/082 ,  B01D63/10 ,  B01D67/0006 ,  B01D67/0079 ,  B01D67/0088 ,  B01D2313/14 ,  B01D2319/025 ,  B01D2319/06 ,  B01D2323/30 ,  B01D2323/40 ,  B01D2325/02 ,  B01D2325/28 ,  B01D2325/36 ,  B01D2325/38 ,  B01J20/28033 ,  B01J20/28035 ,  B01J20/28047 ,  B01J20/28052 ,  B01J20/28085 ,  B01J20/281 ,  B01J20/291 ,  B01L3/50255

Abstract: The present invention discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers ins aid membrane stack.

Abstract translation: 本发明公开了一种膜堆叠，其包括第一和第二膜层以及设置在所述第一和第二膜层之间的间隔层，所述膜叠层构造成使得流体在基本上垂直于所述第一和第二膜层的平面的方向上穿过所述膜堆叠 膜层和所述间隔层。 本申请还公开了一种包括如上所述的膜的模块，所述模块具有基本上垂直于膜的主表面的平面的流体流动路径，并且间隔层有助于膜堆叠。

公开(公告)号：US09962691B2

公开(公告)日：2018-05-08

申请号：US15049625

申请日：2016-02-22

Applicant: Natrix Separations Inc.

Inventor： Amro Ragheb ,  Gary Skarja

IPC: B01J39/26 ,  B01J39/18 ,  B01D15/34 ,  C07K1/18 ,  C07K1/22 ,  B01J39/19

CPC classification number: B01J39/19 ,  B01D15/34 ,  B01J20/267 ,  B01J20/28033 ,  B01J20/291 ,  B01J39/26 ,  C07K1/18 ,  C07K1/22

Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.

公开(公告)号：US20140238935A1

公开(公告)日：2014-08-28

申请号：US14190650

申请日：2014-02-26

Applicant: Natrix Separations Inc.

Inventor： Elena N. Komkova ,  Charles H. Honeyman

IPC: B01J20/32 ,  B01J43/00 ,  B01J20/291 ,  B01D15/36

CPC classification number: B01J20/3285 ,  B01D15/327 ,  B01D15/36 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/291 ,  B01J39/26 ,  B01J41/20 ,  B01J43/00 ,  B01J47/12 ,  C07K1/165

Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.

Abstract translation: 描述了将其用于混合模式层析的复合材料和方法。 在某些实施例中，复合材料包括支撑构件，其包括延伸穿过支撑构件的多个孔; 和多功能交联凝胶。 多功能交联凝胶具有以下功能或特性中的至少两个：阳离子，阴离子，疏水，亲水，亲硫化，给氢氢键，接受氢键，π-π键，π-π键接受或 金属螯合。 复合材料可用于分离或纯化生物分子或生物离子。

公开(公告)号：US20130189322A1

公开(公告)日：2013-07-25

申请号：US13744583

申请日：2013-01-18

Applicant: Natrix Separations Inc.

Inventor： Charles H. Honeyman ,  John A. Chickosky ,  Molly S. McGlaughlin ,  Amro Ragheb

IPC: A61K47/48

CPC classification number: A61K9/7007 ,  G01N33/544

Abstract: Described are composite materials and methods of making and using them for the storage and delivery of unstable drugs or biologics. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; a macroporous cross-linked gel, comprising a plurality of macropores; a therapeutic agent; and a stabilizing agent.

Abstract translation: 描述了制备和使用它们用于储存和递送不稳定药物或生物制剂的复合材料和方法。 在某些实施例中，复合材料包括支撑构件，其包括延伸穿过支撑构件的多个孔; 大孔交联凝胶，其包含多个大孔; 治疗剂; 和稳定剂。

公开(公告)号：US08383782B2

公开(公告)日：2013-02-26

申请号：US12609689

申请日：2009-10-30

Applicant: Ronald F. Childs ,  Carlos Filipe ,  Raja Ghosh ,  Jinsheng Zhou ,  Elena N. Komkova ,  Marcus Y. Kim ,  Tapan K. Dey

Inventor： Ronald F. Childs ,  Carlos Filipe ,  Raja Ghosh ,  Alicja M. Mika ,  Jinsheng Zhou ,  Elena N. Komkova ,  Marcus Y. Kim ,  Tapan K. Dey

IPC: C07K1/14 ,  C07K1/22 ,  C07K17/02 ,  C07K17/08 ,  C12N9/00 ,  C12N11/02 ,  C12N11/08 ,  C12N9/14 ,  C12N9/76 ,  G01N33/544 ,  G01N33/545

CPC classification number: C07K1/04 ,  B01D15/327 ,  B01D15/34 ,  B01D15/36 ,  B01D15/361 ,  B01D15/3804 ,  B01D67/0006 ,  B01D69/02 ,  B01D69/10 ,  B01D69/141 ,  B01D71/40 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2325/12 ,  B01D2325/14 ,  B01D2325/16 ,  B01D2325/38 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28047 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/285 ,  B01J20/286 ,  B01J20/291 ,  B01J20/3064 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3272 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/3282 ,  B01J39/26 ,  B01J41/20 ,  B01J47/018 ,  B01J47/12 ,  C07K1/20 ,  C07K1/22 ,  C07K1/34 ,  Y10S530/812 ,  Y10S530/815 ,  Y10T428/249978 ,  Y10T428/249994

Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.

Abstract translation: 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。

公开(公告)号：US08206982B2

公开(公告)日：2012-06-26

申请号：US12250869

申请日：2008-10-14

Applicant: Ronald F. Childs ,  Carlos Filipe ,  Raja Ghosh ,  Alicja M. Mika ,  Jinsheng Zhou ,  Elena N. Komkova ,  Marcus Y. Kim ,  Tapan K. Dey

Inventor： Ronald F. Childs ,  Carlos Filipe ,  Raja Ghosh ,  Alicja M. Mika ,  Jinsheng Zhou ,  Elena N. Komkova ,  Marcus Y. Kim ,  Tapan K. Dey

IPC: C12N11/08 ,  C12N11/02 ,  C07K1/14 ,  C07K1/16 ,  C07K1/22 ,  C07K17/02 ,  C07K17/08

CPC classification number: C07K1/04 ,  B01D15/327 ,  B01D15/34 ,  B01D15/36 ,  B01D15/361 ,  B01D15/3804 ,  B01D67/0006 ,  B01D69/02 ,  B01D69/10 ,  B01D69/141 ,  B01D71/40 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2325/12 ,  B01D2325/14 ,  B01D2325/16 ,  B01D2325/38 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28047 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/285 ,  B01J20/286 ,  B01J20/291 ,  B01J20/3064 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3272 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/3282 ,  B01J39/26 ,  B01J41/20 ,  B01J47/018 ,  B01J47/12 ,  C07K1/20 ,  C07K1/22 ,  C07K1/34 ,  Y10S530/812 ,  Y10S530/815 ,  Y10T428/249978 ,  Y10T428/249994

Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.

Abstract translation: 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。

公开(公告)号：US20100059443A1

公开(公告)日：2010-03-11

申请号：US12551762

申请日：2009-09-01

Applicant: Damian Brellisford ,  Donna L. Crossley ,  Greg Mclntosh ,  Robert Ruman ,  John Rydall ,  Christopher S. Shields

Inventor： Damian Brellisford ,  Donna L. Crossley ,  Greg Mclntosh ,  Robert Ruman ,  John Rydall ,  Christopher S. Shields

IPC: B01D15/38 ,  B01D35/30 ,  C02F1/42 ,  B01J49/00 ,  B01D15/36

CPC classification number: C07K1/22 ,  B01D63/02 ,  B01D63/024 ,  B01D63/082 ,  B01D63/087 ,  B01D63/10 ,  B01D63/14 ,  B01D69/02 ,  B01D69/10 ,  B01D2315/10 ,  B01D2325/36 ,  B01L3/502753 ,  B01L9/527 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0409 ,  C07K14/77 ,  C07K16/00 ,  C12N9/2462 ,  C12Y302/01017

Abstract: Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.

Abstract translation: 本文描述的是用于切向流过滤的流体处理装置，包括壳体单元和复合材料，其中复合材料包括：支撑构件，其包括延伸穿过支撑构件的多个孔; 以及包含平均尺寸为10nm〜3000nm的大孔的非自支撑大孔交联凝胶，所述大孔凝胶位于所述支撑体的孔中。 本发明还涉及一种从流体中分离物质的方法，包括将流体与本发明装置接触的步骤，从而将物质吸附或吸收到其中所含的复合材料中。

公开(公告)号：US10195567B2

公开(公告)日：2019-02-05

申请号：US15876891

申请日：2018-01-22

Applicant: Natrix Separations, Inc.

Inventor： Dharmeshkumar M. Kanani ,  Navneet Sidhu ,  Bradley A. Kachuik ,  Charles H. Honeyman

IPC: B01D61/00 ,  B01D69/12 ,  B01D63/10

Abstract: Described are wrapped fluid treatment elements, comprising: a composite material; an interleaf; and an inner core; wherein the composite material and the interleaf form layers wrapped around the inner core. The composite material and interleaf may be wrapped in a spiral configuration around the inner core. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device or element, thereby adsorbing or absorbing the substance to the composite material contained therein.

公开(公告)号：US08367809B2

公开(公告)日：2013-02-05

申请号：US12609653

申请日：2009-10-30

Applicant: Ronald F. Childs ,  Carlos Filipe ,  Raja Ghosh ,  Jinsheng Zhou ,  Elena N. Komkova ,  Marcus Y. Kim ,  Tapan K. Dey

Inventor： Ronald F. Childs ,  Carlos Filipe ,  Raja Ghosh ,  Alicja M. Mika ,  Jinsheng Zhou ,  Elena N. Komkova ,  Marcus Y. Kim ,  Tapan K. Dey

IPC: C07K1/14 ,  C12N11/08 ,  C12N11/02 ,  C12N5/00 ,  C07K1/16 ,  C07K1/22 ,  C07K17/02 ,  C07K17/08

CPC classification number: C07K1/04 ,  B01D15/327 ,  B01D15/34 ,  B01D15/36 ,  B01D15/361 ,  B01D15/3804 ,  B01D67/0006 ,  B01D69/02 ,  B01D69/10 ,  B01D69/141 ,  B01D71/40 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2325/12 ,  B01D2325/14 ,  B01D2325/16 ,  B01D2325/38 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28047 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/285 ,  B01J20/286 ,  B01J20/291 ,  B01J20/3064 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3272 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/3282 ,  B01J39/26 ,  B01J41/20 ,  B01J47/018 ,  B01J47/12 ,  C07K1/20 ,  C07K1/22 ,  C07K1/34 ,  Y10S530/812 ,  Y10S530/815 ,  Y10T428/249978 ,  Y10T428/249994

Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.

Abstract translation: 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。

公开(公告)号：US08206958B2

公开(公告)日：2012-06-26

申请号：US11950562

申请日：2007-12-05

Applicant: Ronald F. Childs ,  Tapan K. Dey ,  Carlos Filipe ,  Raja Ghosh ,  Marcus Y. Kim ,  Elena N. Komkova ,  Alicja M. Mika ,  Jinsheng Zhou

Inventor： Ronald F. Childs ,  Tapan K. Dey ,  Carlos Filipe ,  Raja Ghosh ,  Marcus Y. Kim ,  Elena N. Komkova ,  Alicja M. Mika ,  Jinsheng Zhou

IPC: C12N9/00 ,  C12N11/02 ,  C12N11/08 ,  C12N9/14 ,  C12N9/76 ,  C01N33/544 ,  C01N33/545 ,  C07K1/14 ,  C07K1/22 ,  C07K17/02 ,  C07K17/08

CPC classification number: C07K1/04 ,  B01D15/327 ,  B01D15/34 ,  B01D15/36 ,  B01D15/361 ,  B01D15/3804 ,  B01D67/0006 ,  B01D69/02 ,  B01D69/10 ,  B01D69/141 ,  B01D71/40 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2325/12 ,  B01D2325/14 ,  B01D2325/16 ,  B01D2325/38 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28047 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/285 ,  B01J20/286 ,  B01J20/291 ,  B01J20/3064 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3272 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/3282 ,  B01J39/26 ,  B01J41/20 ,  B01J47/018 ,  B01J47/12 ,  C07K1/20 ,  C07K1/22 ,  C07K1/34 ,  Y10S530/812 ,  Y10S530/815 ,  Y10T428/249978 ,  Y10T428/249994

Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.

Abstract translation: 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。