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公开(公告)号：US10666256B2
公开(公告)日：2020-05-26
申请号：US16185921
申请日：2018-11-09
Applicant: STC.UNM
Inventor： James Plusquellic , James Aarestad
Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.
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公开(公告)号：US20200158720A1
公开(公告)日：2020-05-21
申请号：US16707501
申请日：2019-12-09
Applicant: STC.UNM
Inventor： David G. Whitten , Harry Craig Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying Wang , Patrick L. Donabedian , Kiran Bhaskar
Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
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公开(公告)号：US10591491B1
公开(公告)日：2020-03-17
申请号：US16262168
申请日：2019-01-30
Applicant: STC.UNM
Inventor： Ke Jian Liu , Wenlan Liu , Graham Timmins , Rong Pan
IPC: G01N33/68
Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
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公开(公告)号：US10548994B1
公开(公告)日：2020-02-04
申请号：US14196343
申请日：2014-03-04
Applicant: STC.UNM
Inventor： Erin Damita Milligan , Jeffrey P. Norenberg
IPC: A61K31/4166 , A61K51/04 , A61K31/4174 , A61K38/18 , A61K38/20 , A61K38/34
Abstract: In one embodiment, the invention provides a method of treating a subject suffering from chronic neuropathic pain and/or allodynia by administering a therapeutically-effective amount of at least one LFA1 antagonist to the subject. In a preferred embodiment, the invention provides a method of treating a subject suffering from chronic neuropathic pain and/or allodynia, the method comprising administering intrathecally to the subject a therapeutically-effective amount of microparticles comprising PLGA-encapsulated pDNA-IL-10, optionally in combination with a therapeutically-effective amount of intrathecally-administered CpG oligodeoxynucleotide (CpG ODN) and/or at least one LFA1 antagonist.
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公开(公告)号：US20200015477A1
公开(公告)日：2020-01-16
申请号：US16520847
申请日：2019-07-24
Applicant: Ivy Foo-Hurwitz , Ravi Durvasula , Scott Matthews , Michael Workman
Inventor： Ivy Foo-Hurwitz , Ravi Durvasula , Scott Matthews , Michael Workman
Abstract: A larvicide comprising an essential oil encapsulated within a non-viable yeast cell. The larvicide is particularly effective against mosquito larvae, non-toxic to humans and other non-target species, inexpensive to make, and non-toxic during manufacture, transport, and storage.
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Patent Agency Ranking
公开(公告)号：US10512651B2
公开(公告)日：2019-12-24
申请号：US15506421
申请日：2015-08-21
Applicant: STC.UNM
Inventor： Ellen Janine Beswick
IPC: A61K31/554 , A61K38/00 , A61K31/553 , A61K31/167 , A61K45/06 , A61K31/4709 , A61K31/496 , A61K31/551 , A61P35/00 , A61K31/165
Abstract: The present invention relates to the discovery that MK2 is highly expressed in cancer tissue and the inhibition of MK2 using an MK2 inhibitor represents a viable approach to the treatment of cancer, including drug resistant cancers, metastatic cancers and recurrent cancers. MK2 inhibitors as described herein may be used alone or in combination with an at least one additional anti-cancer agent for the treatment of cancer.
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公开(公告)号：US10483415B2
公开(公告)日：2019-11-19
申请号：US15904296
申请日：2018-02-23
Applicant: STC.UNM
Inventor： Sang Eon Han , Brittany R. Hoard , Sang M. Han , Swapnadip Ghosh
IPC: G02B1/00 , H01L31/0236 , H01L31/18 , H01L31/0747 , H01L31/20 , H03H9/10 , H03H9/145 , H03H9/25
Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.
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公开(公告)号：US10483105B2
公开(公告)日：2019-11-19
申请号：US15573772
申请日：2016-05-13
Applicant: STC.UNM
Inventor： Seung-Chang Lee , Steven R. J. Brueck
IPC: H01L21/02 , B81C1/00 , B82Y10/00 , H01L21/8238 , H01L29/423 , H01L29/66 , H01L27/092 , H01L29/786 , H01L29/06 , H01L21/285 , H01L21/306 , H01L21/311 , B82Y40/00
Abstract: Provided is a method for growing a nanowire, including: providing a substrate with a base portion having a first surface and at least one support structure extending above or below the first surface; forming a dielectric coating on the at least one support structure; forming a photoresist coating over the substrate; forming a metal coating over at least a portion of the dielectric coating; removing a portion of the dielectric coating to expose a surface of the at least one support structure; removing a portion of the at least one support structure to form a nanowire growth surface; growing at least one nanowire on the nanowire growth surface of a corresponding one of the at least one support structure, wherein the nanowire comprises a root end attached to the growth surface and an opposing, free end extending from the root end; and elastically bending the at least one nanowire.
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公开(公告)号：US20190227050A1
公开(公告)日：2019-07-25
申请号：US16215139
申请日：2018-12-10
Applicant: STC.UNM
Inventor： Steven R.J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza
IPC: G01N33/487 , C23C16/50 , C23C16/455 , C23C16/34 , B01L3/00 , C12Q1/6869 , G01N21/65
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
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公开(公告)号：US10254295B2
公开(公告)日：2019-04-09
申请号：US15463274
申请日：2017-03-20
Applicant: STC.UNM
Inventor： Ke Jian Liu , Wenlan Liu , Graham Timmins , Rong Pan
IPC: G01N33/68
Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
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