公开(公告)号：US09974883B2

公开(公告)日：2018-05-22

申请号：US15674309

申请日：2017-08-10

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Morshed Khandaker ,  Shahram Riahinezhad

IPC分类号： A61F2/28 ,  A61L24/10 ,  A61L24/06 ,  A61L24/00 ,  A61L24/02 ,  A61K38/18 ,  A61F2/30 ,  A61F2/36 ,  A61B17/56 ,  A61B17/86

CPC分类号： A61L24/102 ,  A61B17/866 ,  A61B2017/564 ,  A61B2017/8655 ,  A61F2/2846 ,  A61F2/30723 ,  A61F2/30734 ,  A61F2/3601 ,  A61F2002/30736 ,  A61F2310/00011 ,  A61K38/1841 ,  A61K38/1875 ,  A61L24/0015 ,  A61L24/0089 ,  A61L24/0094 ,  A61L24/02 ,  A61L24/06 ,  A61L24/108 ,  A61L2300/102 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/02 ,  C08L33/12 ,  C08L67/04

摘要： The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.

公开(公告)号：US20180110899A1

公开(公告)日：2018-04-26

申请号：US15850308

申请日：2017-12-21

申请人： DePuy International Limited

发明人： Saad Abdul Majeed Ali

IPC分类号： A61L27/12 ,  A61L24/02 ,  A61L24/00 ,  A61L27/18 ,  A61L27/58 ,  A61L27/54

CPC分类号： A61L27/12 ,  A61L24/0015 ,  A61L24/02 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/216 ,  A61L2300/412 ,  A61L2430/02 ,  C08L67/04

摘要： A bone filler composition including a mixture of a curable calcium phosphate based bone filler which is formed from a liquid component and a calcium phosphate based powder component, and a formulation which comprises a bisphosphonate in particulate form. The particles of the bisphosphonate being embedded in particles of a polymeric material which resorbs when the formulation is implanted.

公开(公告)号：US20180085490A1

公开(公告)日：2018-03-29

申请号：US15577067

申请日：2016-05-27

申请人： LAUNCHPAD MEDICAL, LLC

发明人： George W. Kay ,  Brian J. Hess

IPC分类号： A61L27/12 ,  A61L24/02 ,  A61L24/00 ,  A61L27/58 ,  A61L27/36 ,  A61L27/02 ,  A61K6/00 ,  A61K6/06 ,  A61K6/033 ,  A61C5/35 ,  A61C5/70 ,  A61C13/271 ,  A61F2/28 ,  A61C8/00 ,  A61F2/44

CPC分类号： A61L27/12 ,  A61C5/35 ,  A61C5/70 ,  A61C8/0009 ,  A61C13/26 ,  A61F2/2803 ,  A61F2/4455 ,  A61F2002/2835 ,  A61F2002/30448 ,  A61K6/0023 ,  A61K6/0047 ,  A61K6/0085 ,  A61K6/033 ,  A61K6/0643 ,  A61K6/0675 ,  A61L24/0005 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/02 ,  A61L27/025 ,  A61L27/3604 ,  A61L27/3616 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/10 ,  A61L2430/12 ,  A61L2430/24 ,  A61L2430/34 ,  A61L2430/38

摘要： The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

公开(公告)号：US09907879B2

公开(公告)日：2018-03-06

申请号：US15032485

申请日：2014-10-30

申请人： BK Giulini GMBH

发明人： Henrike Thauern ,  Thomas Staffel

IPC分类号： A61L24/02 ,  A61L15/18 ,  A61L15/44 ,  A61L26/00 ,  A61L24/08 ,  A61L24/10

CPC分类号： A61L24/02 ,  A61L15/18 ,  A61L15/44 ,  A61L24/08 ,  A61L24/106 ,  A61L24/108 ,  A61L26/0004 ,  A61L26/0066 ,  A61L2300/112 ,  A61L2300/418 ,  A61L2400/04

摘要： The present invention relates to the use of polyphosphate in crystalline form for treatment of wounds, especially bleeding wounds, wherein the anion of the polyphosphate has a (numerical) average of at least 4 phosphorus atoms per polyphosphate anion. The invention additionally relates to a composition suitable for treatment of wounds, especially bleeding wounds, comprising an inventive polyphosphate and a carrier material. The invention further provides a method suitable for production of the inventive composition, which comprises the introduction of the polyphosphate and optionally further haemostatic agents into the carrier material, or into a component or into a precursor of the carrier material.

公开(公告)号：US20180028194A1

公开(公告)日：2018-02-01

申请号：US15554850

申请日：2016-03-02

申请人： ACCURATE MEDICAL THERAPEUTICS LTD.

发明人： Michael Gabriel TAL ,  Eran MILLER

IPC分类号： A61B17/12 ,  A61K9/00 ,  A61L24/00 ,  A61L24/02 ,  A61K9/16 ,  A61K31/704

CPC分类号： A61F2/013 ,  A61B17/12109 ,  A61B17/12181 ,  A61B17/12186 ,  A61B2017/1205 ,  A61F2002/011 ,  A61F2002/016 ,  A61K9/0019 ,  A61K9/1676 ,  A61K31/704 ,  A61L24/0015 ,  A61L24/02 ,  A61L2300/23 ,  A61L2300/416 ,  A61L2430/36 ,  A61M5/007 ,  A61M25/0021 ,  A61M25/007 ,  A61M25/0074 ,  A61M2025/0042

摘要： Injectable embolization particulates (e.g., particles, microstructures, beads) employed in embolization procedures, for facilitating blood vessel occlusion. Exemplary embolization particulates for occluding a blood vessel include a plurality of embolization beads, each bead having a plurality of outwardly protruding portions, wherein, upon a first one and a second one of the beads accumulating against a boundary of the blood vessel, protruding portions of the first bead are configured to intermesh with protruding portions of the second bead, so as to occlude the blood vessel. Also disclosed are compositions of embolization particulates including a plurality of shaped embolization beads, and methods for embolizing or occluding a blood vessel using embolization particulates or compositions thereof. Embolization particulates have particular shapes for facilitating blood vessel occlusion while preventing or diminishing back flow (reflux) of embolic material, and may be coated or impregnated with therapeutic agents or radioactive isotopes, for increasing desirable therapeutic effects.

公开(公告)号：US09867899B2

公开(公告)日：2018-01-16

申请号：US15131583

申请日：2016-04-18

申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION

发明人： Russell J. Stewart

IPC分类号： A61L24/02 ,  A61L24/04 ,  A61L24/06 ,  A61L24/10 ,  D07B3/00 ,  A61L24/00 ,  A61L27/26 ,  A61L27/54 ,  C08F8/00 ,  C08F8/06

CPC分类号： A61L24/046 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/043 ,  A61L24/06 ,  A61L24/10 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/62 ,  A61L2430/16 ,  C08F8/00 ,  C08F8/06 ,  C08L89/00

摘要： Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex coacervates described herein can be subsequently cured to produce strong, cohesive adhesives. The reinforced adhesive complex coacervates have several desirable features when compared to conventional adhesives. The reinforced adhesive complex coacervates are effective in wet or underwater applications. The reinforced adhesive complex coacervates described herein, being phase separated from water, can be applied underwater without dissolving or dispersing into the water. The reinforced adhesive complex coacervates have numerous biological applications as bioadhesives and bioactive delivery devices. In particular, the reinforced adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, wet tissues in physiological conditions.

公开(公告)号：US09757493B2

公开(公告)日：2017-09-12

申请号：US15149986

申请日：2016-05-09

申请人： Pioneer Surgical Technology, Inc.

发明人： Juchui Ray Lin ,  Edward S. Ahn ,  Brian M. Schlossberg

IPC分类号： A61K6/083 ,  A61L24/06 ,  A61K6/08 ,  A61L24/04 ,  A61L24/02 ,  A61K6/033

CPC分类号： A61L24/06 ,  A61K6/033 ,  A61K6/08 ,  A61K6/083 ,  A61L24/02 ,  A61L24/04 ,  A61L24/046 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12

摘要： Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

公开(公告)号：US20170216485A1

公开(公告)日：2017-08-03

申请号：US15326420

申请日：2015-07-16

申请人： Nanyang Technological University

发明人： Dongan Wang ,  Changjiang Fan

IPC分类号： A61L24/10 ,  A61L24/00 ,  A61L24/02

CPC分类号： A61L24/104 ,  A61L24/0031 ,  A61L24/02 ,  A61L24/043 ,  A61L24/10 ,  C08L89/00

摘要： A biological tissue adhesive composition is provided. The biological tissue adhesive composition comprises one or more macromolecules grafted with at least one catechol moiety and comprising at least one cross-linkable functional group, a first cross-linker for cross-linking the at least one catechol moiety, wherein the first cross-linker comprises or consists or 10 a multivalent metal ion, and a second cross-linker for covalently cross-linking the at least one cross-linkable functional group, wherein the one or more macromolecules are cross-linked by (a) complex formation between the at least one catechol moiety and the multivalent metal ion, and (b) covalent bonding of the at least one cross-linkable functional group with the second cross-linker. Fabrication method and working principle of a biological tissue adhesive 15 composition are also provided.

公开(公告)号：US09669132B1

公开(公告)日：2017-06-06

申请号：US15404566

申请日：2017-01-12

申请人： Cook Medical Technologies LLC

发明人： Alan George Brownlee ,  Christopher Malcolm Elvin

IPC分类号： A61K31/74 ,  A61K9/00 ,  A01N25/34 ,  A61B17/08 ,  A61F13/00 ,  A61L24/10 ,  C09J189/00

CPC分类号： A61L24/106 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/10 ,  A61L2400/04 ,  C08J3/24 ,  C08J2389/00 ,  C09J189/00

摘要： A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photoactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.

公开(公告)号：US20170128616A1

公开(公告)日：2017-05-11

申请号：US15346236

申请日：2016-11-08

申请人： Omrix Biopharmaceuticals Lts. ,  Ethicon, Inc.

发明人： Erez ILAN ,  Omri Faingold ,  Nataly Freizus ,  Ronen Eavri ,  Dwayne Looney ,  Sridevi Dhanaraj ,  James Galloway ,  Walter Danker

IPC分类号： A61L24/08 ,  A61L24/00 ,  A61L24/02

CPC分类号： A61L26/0023 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/043 ,  A61L24/06 ,  A61L24/08 ,  A61L26/00 ,  A61L26/0004 ,  A61L2300/106 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  C08L1/04

摘要： The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.