公开(公告)号：US20150011932A1

公开(公告)日：2015-01-08

申请号：US14494894

申请日：2014-09-24

申请人： Boston Scientific Scimed, Inc.

发明人： Aaron Khieu ,  John Jianhua Chen ,  Ying Xiong ,  Joe Khammoungkhoune ,  Daniel James Horn ,  John Blix

IPC分类号： A61M25/10 ,  A61L29/14 ,  A61L29/04

CPC分类号： A61M25/10 ,  A61L29/049 ,  A61L29/14 ,  A61L29/143 ,  A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1088 ,  A61M2205/0216 ,  B32B5/02 ,  C08L23/06 ,  C08L75/04 ,  C08L77/00 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1362 ,  Y10T428/1366 ,  Y10T428/1372 ,  Y10T428/1386

摘要： Composite fiber reinforced balloons for medical devices are prepared by applying a web of fibers to the exterior of a preformed underlayer balloon, encasing the web with a matrix material to form an assembly, and inserting the assembly into a preformed outer layer balloon to form the composite balloon.

摘要翻译： 用于医疗装置的复合纤维增强球囊通过将纤维网施加到预成型下层球囊的外部，用基质材料包裹纤维网以形成组件并将组件插入预成型的外层气囊中以形成复合物 气球。

公开(公告)号：US20140128801A1

公开(公告)日：2014-05-08

申请号：US13975228

申请日：2013-08-23

申请人： AngioScore, Inc.

发明人： Ulrich Speck ,  Madeleine Caroline Berg

IPC分类号： A61L29/16 ,  A61L29/08

CPC分类号： A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

摘要翻译： 本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种氧化不敏感药物或不含氧化物的无氧化物的药物制剂和至少一种亲脂性抗氧化剂，其比例为3-100％ 的至少一种亲脂性抗氧化剂相对于100重量％的药物，其中所述至少一种氧化不敏感药物选自紫杉烷类，沙利度胺，他汀类，皮质激素和皮质激素的亲脂性衍生物，并且所述至少一种 亲脂性抗氧化剂选自去甲二氢愈创木酸，白藜芦醇和没食子酸丙酯。

公开(公告)号：US08697212B2

公开(公告)日：2014-04-15

申请号：US13735111

申请日：2013-01-07

申请人： Boston Scientific Scimed, Inc.

发明人： Aaron Khieu ,  John J. Chen ,  Ying Xiong ,  Joe Khammoungkhoune ,  Daniel J. Horn ,  John Blix

IPC分类号： B32B1/00 ,  A61M29/00

CPC分类号： A61M25/10 ,  A61L29/049 ,  A61L29/14 ,  A61L29/143 ,  A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1088 ,  A61M2205/0216 ,  B32B5/02 ,  C08L23/06 ,  C08L75/04 ,  C08L77/00 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1362 ,  Y10T428/1366 ,  Y10T428/1372 ,  Y10T428/1386

摘要： A fiber reinforced laminate composite balloon comprising an underlying balloon layer, a fiber web disposed over the underlying balloon layer, a matrix material encasing the web and an overlying balloon layer of radially oriented polymer material disposed over the fiber web and matrix material.

摘要翻译： 一种纤维增强层压复合球囊，其包括下面的球囊层，设置在下面的球囊层上的纤维网，包围腹板的基质材料和布置在纤维网和基质材料上的径向取向的聚合物材料的上覆球囊层。

公开(公告)号：US20130023817A1

公开(公告)日：2013-01-24

申请号：US13628627

申请日：2012-09-27

申请人： Ulrich Speck ,  Madeleine Caroline Berg

发明人： Ulrich Speck ,  Madeleine Caroline Berg

IPC分类号： A61M37/00

CPC分类号： A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.

摘要翻译： 本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种药物或药物制剂和至少一种亲脂性抗氧化剂，其比例为至少一种亲脂性抗氧化剂的3-100重量％ 相对于100重量％的药物，其中排除了至少一种药物和至少一种亲脂性抗氧化剂作为药物的组合，其中所述至少一种亲脂性抗氧化剂是丁基化羟基甲苯。

公开(公告)号：US20190216985A1

公开(公告)日：2019-07-18

申请号：US16324460

申请日：2017-08-09

申请人： TELEFLEX LIFESCIENCES UNLIMITED COMPANY

发明人： Denzell MCBURNEY ,  Ronald John KELLY ,  Morgan TIERNEY

IPC分类号： A61L29/08 ,  A61M25/00 ,  A61L29/14 ,  A61L2/08 ,  B65B55/16

CPC分类号： A61L27/505 ,  A61L2/081 ,  A61L2/10 ,  A61L27/34 ,  A61L27/50 ,  A61L27/52 ,  A61L29/08 ,  A61L29/085 ,  A61L29/14 ,  A61L29/143 ,  A61L29/145 ,  A61L2202/18 ,  A61L2202/24 ,  A61L2400/10 ,  A61L2420/02 ,  A61M25/002 ,  B65B55/16 ,  C08J3/03 ,  C08K5/06 ,  C08K5/1345 ,  C08L1/286

摘要： A method of producing a ready-to-use medical device with a functional coating includes the steps of bringing the medical device, at least with its functional coating, in contact with a composition which prevents or retards degradation of the functional coating and sterilizing the medical device and the composition via radiation. A method leads to an improved product, namely an improved ready-to-use medical device which does not suffer a loss of quality during sterilization and storage. The composition comprises carboxymethyl cellulose or a derivative or salt thereof and/or an antioxidant selected from gallic acid or a derivative thereof.

公开(公告)号：US20190201589A1

公开(公告)日：2019-07-04

申请号：US16325538

申请日：2017-08-29

申请人： Hollister Incorporated

发明人： David J. Farrell ,  Padraig M. O'Flynn ,  John P. O'Mahony ,  Richard Meaney ,  John T. Clarke

IPC分类号： A61L29/14

CPC分类号： A61L29/141 ,  A61L29/143 ,  A61L2400/10 ,  A61L2400/18

摘要： Methods of varying the stiffness of polymeric medical tubes.

公开(公告)号：US09962463B2

公开(公告)日：2018-05-08

申请号：US15184228

申请日：2016-06-16

申请人： Orhun K. Muratoglu ,  Stephen H. Spiegelberg

发明人： Orhun K. Muratoglu ,  Stephen H. Spiegelberg

IPC分类号： A61L27/16 ,  A61L27/44 ,  A61L27/50 ,  A61L29/04 ,  A61L29/14 ,  A61L31/04 ,  A61L31/14 ,  C08J3/22 ,  C08J3/28 ,  C08J3/24 ,  C08K5/1545

CPC分类号： A61L27/16 ,  A61L27/505 ,  A61L29/041 ,  A61L29/143 ,  A61L31/048 ,  A61L2430/02 ,  C08J3/226 ,  C08J3/247 ,  C08J3/28 ,  C08J2323/06 ,  C08J2423/00 ,  C08K5/1545 ,  C08K2201/012 ,  C08L23/06 ,  C08L2666/02 ,  C08K5/005

摘要： The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.

公开(公告)号：US20180037726A1

公开(公告)日：2018-02-08

申请号：US15642701

申请日：2017-07-06

申请人： Veerag Mehta

发明人： Veerag Mehta

IPC分类号： C08L23/06 ,  A61L31/04 ,  A23L29/00 ,  D01F6/46 ,  D01F6/94 ,  C08J5/18 ,  C08L83/04

CPC分类号： C08L23/06 ,  A23L29/00 ,  A23V2002/00 ,  A61L29/049 ,  A61L29/143 ,  A61L31/041 ,  A61L31/143 ,  C08J5/18 ,  C08J2323/06 ,  C08J2383/04 ,  C08J2483/04 ,  C08L83/04 ,  C08L2203/16 ,  C08L2203/18 ,  C08L2205/06 ,  C08L2207/068 ,  D01F6/46 ,  D01F6/94

摘要： Ultrahigh molecular weight, or high molecular weight silicone is added to ultrahigh molecular weight polyethylene polymer during the compounding process. It creates a material composition that is processable by traditional injection molding and extrusion processes that rely on shear as a primary means of melting and helping to shape end products.

公开(公告)号：US09603974B2

公开(公告)日：2017-03-28

申请号：US14496058

申请日：2014-09-25

申请人： TERUMO KABUSHIKI KAISHA

发明人： Keiko Yamashita ,  Shigenori Nozawa

IPC分类号： A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61F2/93 ,  A61L31/08 ,  A61L31/14 ,  A61M25/10

CPC分类号： A61K31/337 ,  A61F2/93 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61K47/10 ,  A61K47/183 ,  A61L29/08 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/143 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/06 ,  A61M25/10 ,  A61M2025/105 ,  C08L77/04

摘要： A coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process is provided. The coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydropathy index of the amino acid of zero or less than zero, and salts thereof. A drug coating layer, a drug-eluting medical device and a method of treatment are also provided.

公开(公告)号：US20150297797A1

公开(公告)日：2015-10-22

申请号：US14731715

申请日：2015-06-05

申请人： AngioScore, Inc.

发明人： Ulrich Speck ,  Madeleine Caroline Berg

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61M25/10

CPC分类号： A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

摘要翻译： 本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种氧化不敏感药物或不含氧化物的无氧化物的药物制剂和至少一种亲脂性抗氧化剂，其比例为3-100％ 所述至少一种亲脂性抗氧化剂相对于所述药物的100重量％，其中所述至少一种氧化不敏感药物选自紫杉烷，沙利度胺，他汀类，皮质激素和皮质激素的亲脂性衍生物，并且所述至少一种 亲脂性抗氧化剂选自去甲二氢愈创木酸，白藜芦醇和没食子酸丙酯。