公开(公告)号：US11883655B2

公开(公告)日：2024-01-30

申请号：US17182436

申请日：2021-02-23

Applicant: Boston Scientific Scimed, Inc.

Inventor： Kyle Harish Srivastava ,  Vijay Koya ,  Thomas Lee Williams ,  Miles Kealy ,  Nicholas Barron

IPC: A61N1/36 ,  A61N1/40 ,  A61N1/05 ,  A61N1/08

CPC classification number: A61N1/36002 ,  A61N1/0509 ,  A61N1/08 ,  A61N1/36007 ,  A61N1/40

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system herein can include an electric field generating circuit configured to generate one or more electric fields, and control circuitry. The system can include one or more electrodes disposed on a first stimulation lead to deliver the electric fields to a site of a cancerous tumor within a patient and one or more electrodes disposed on a second stimulation lead to deliver the electric fields to the site of a cancerous tumor within a patient. The first and second stimulation leads can be configured to be implanted on or about a duodenum. The electric field generating circuit can generate electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.

公开(公告)号：US11872086B2

公开(公告)日：2024-01-16

申请号：US16675690

申请日：2019-11-06

Applicant: ClearPoint Neuro, Inc.

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B5/05 ,  A61B90/11 ,  A61B34/20 ,  A61B5/00 ,  A61N1/05 ,  G01R33/28 ,  G01R33/34 ,  A61B5/369 ,  A61B5/055 ,  A61B34/10 ,  A61B90/14 ,  A61M39/08 ,  A61N1/08 ,  A61N1/372 ,  A61B90/00 ,  A61B17/00 ,  A61N1/37 ,  G01R33/48

CPC classification number: A61B90/11 ,  A61B5/055 ,  A61B5/369 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/34084 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61N1/086 ,  A61N1/372 ,  A61N1/3718 ,  G01R33/288 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

公开(公告)号：US20230402189A1

公开(公告)日：2023-12-14

申请号：US18332091

申请日：2023-06-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ying Li ,  Wentai Liu ,  Yi-Kai Lo

IPC: G16H50/50 ,  A61N1/36 ,  G16H20/40 ,  G16H30/40 ,  G16H70/20 ,  A61B5/055 ,  A61B5/00 ,  A61B6/03 ,  A61N1/08 ,  A61N1/20 ,  G06F17/11 ,  G06F30/23 ,  A61B5/369 ,  A61B5/389

CPC classification number: G16H50/50 ,  A61N1/36031 ,  G16H20/40 ,  G16H30/40 ,  G16H70/20 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/032 ,  A61N1/08 ,  A61N1/205 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36014 ,  G06F17/11 ,  G06F30/23 ,  A61B5/369 ,  A61B5/389 ,  G06F2111/10

Abstract: Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.

公开(公告)号：US20230372724A1

公开(公告)日：2023-11-23

申请号：US18203020

申请日：2023-05-29

Applicant: BIOS S.R.L.

Inventor： Lorenzo CASALINO ,  Aldo CASALINO

IPC: A61N2/00 ,  A61M37/00 ,  A61N1/08 ,  A61N1/40 ,  A61N2/02

CPC classification number: A61N2/002 ,  A61M37/00 ,  A61N1/08 ,  A61N1/403 ,  A61N2/004 ,  A61N2/02 ,  A61M2037/0007 ,  A61N2001/083

Abstract: Devices for cosmetically treating a patient's skin tissue are disclosed, the device comprising a flexible pad adapted to conform to shape of a skin surface of the patient when placed on the skin surface, the flexible pad carrying at least one radio frequency (RF) electrode configured and operable to heat one or more layers of the skin tissue, and at least one electrical muscle stimulating (EMS) electrode configured and operable to cause contraction and relaxation of the one or more muscles; the device being connectable to an external control unit for receiving the RF and EMS signals to apply the cosmetic skin treatment; the device may comprise one or more accelerometers and/or temperature sensors that give feedback about the skin treatment.

公开(公告)号：US20230372614A1

公开(公告)日：2023-11-23

申请号：US18362880

申请日：2023-07-31

Applicant: Ivan Osorio

Inventor： Ivan Osorio

IPC: A61M5/172 ,  A61N1/36 ,  A61B5/16 ,  G16H50/30 ,  G16H10/60 ,  A61B5/0205 ,  A61N5/06 ,  A61N1/02 ,  A61N1/08 ,  G16H20/17 ,  G16H40/63 ,  G16H50/70 ,  A61B5/00

CPC classification number: A61M5/1723 ,  A61N1/36021 ,  A61B5/165 ,  G16H50/30 ,  G16H10/60 ,  A61B5/0205 ,  A61N5/0625 ,  A61N1/025 ,  A61N1/08 ,  G16H20/17 ,  G16H40/63 ,  G16H50/70 ,  A61B5/4839 ,  A61B5/4824 ,  A61B5/02055 ,  A61M2205/332 ,  A61M2205/3584 ,  A61M2230/63 ,  A61M2205/8206 ,  A61B3/11

Abstract: Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

公开(公告)号：US20230330009A1

公开(公告)日：2023-10-19

申请号：US18205718

申请日：2023-06-05

Applicant: The Foundry, LLC

Inventor： Mark E. Deem ,  Hanson Gifford

IPC: A61K9/00 ,  A61K38/16 ,  A61K38/48 ,  A61K41/00 ,  A61N1/32 ,  A61N1/08 ,  A61N1/30 ,  A61N7/00 ,  A61B18/14 ,  A61B18/18 ,  A61N5/10 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K38/164 ,  A61K38/168 ,  A61K38/4893 ,  A61K41/00 ,  A61K41/0028 ,  A61N1/327 ,  A61K9/0078 ,  A61N1/08 ,  A61N1/303 ,  A61N7/00 ,  A61B18/1492 ,  A61B18/1815 ,  A61N5/10 ,  A61K41/0047 ,  A61M37/00 ,  A61M37/0092 ,  C12Y304/24069 ,  Y02A50/30 ,  A61B2018/0016

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

公开(公告)号：US11745022B2

公开(公告)日：2023-09-05

申请号：US16688855

申请日：2019-11-19

Applicant: SORIN CRM SAS

Inventor： Etienne Julien ,  Nicolas Shan ,  Maxime Rault

IPC: A61N1/375 ,  A61N1/05 ,  A61N1/08 ,  A61N1/39

CPC classification number: A61N1/3752 ,  A61N1/0563 ,  A61N1/08 ,  A61N1/3956

Abstract: The present invention relates to an implantable lead comprising at least one conductive wire and a connector. The connector is configured to be connected to an implantable medical device, such as a cardiac stimulation, a defibrillation or/and a neuromodulation device, and further comprising a strain relief device extending longitudinally along an axis from one end of the connector and essentially parallel to the longitudinal axis of the connector. The conductive wire is deflected by a deflection wall of the strain relief device such that the deflection wall of the strain relief device blocks the conductive wire against the deflection wall when the conductive wire is stressed in tension, and the deflection wall extends along an axis which is misaligned with the longitudinal axis of the strain relief device.

公开(公告)号：US20230264016A1

公开(公告)日：2023-08-24

申请号：US18310307

申请日：2023-05-01

Applicant: Envoy Medical Corporation

Inventor： Paul R. Mazanec

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/04 ,  A61N1/378 ,  A61N1/372 ,  G16H40/67 ,  H04W4/80 ,  A61N1/02 ,  A61N1/08 ,  H04W12/50

CPC classification number: A61N1/0541 ,  A61N1/36038 ,  A61N1/0488 ,  A61N1/378 ,  A61N1/37217 ,  A61N1/36171 ,  A61N1/37235 ,  A61N1/37282 ,  A61N1/36039 ,  A61N1/37241 ,  G16H40/67 ,  H04W4/80 ,  A61N1/025 ,  A61N1/08 ,  A61N1/37247 ,  A61N1/37258 ,  H04W12/50

Abstract: Cochlear implant systems can include a cochlear electrode, a stimulator in electrical communication with the cochlear electrode, a sensor configured to receive a stimulus signal and generate an input signal based on the received stimulus signal, and a signal processor in communication with the stimulator and the sensor. The signal processor can include an analog filtering stage configured to generate an analog filtered signal from a received input signal and a digital filtering stage configured to generate a digitally filtered signal from the analog filtered signal. The analog filtering stage and digital filtering stage can be used to normalize the frequency response of the digitally filtered signal with respect to the stimulus signal.

公开(公告)号：US11730959B2

公开(公告)日：2023-08-22

申请号：US17196176

申请日：2021-03-09

Applicant: Neurometrix, Inc.

Inventor： Shai N. Gozani ,  Xuan Kong ,  Thomas C. Ferree

IPC: A61N1/36 ,  A61B5/11 ,  G06F1/3231 ,  G06F3/0346 ,  G06F1/16 ,  A61B5/00 ,  A61N1/04 ,  A61N1/08 ,  G06F3/01

CPC classification number: A61N1/36021 ,  A61B5/1118 ,  A61B5/1123 ,  A61B5/7475 ,  A61N1/0456 ,  A61N1/0492 ,  A61N1/08 ,  A61N1/36031 ,  G06F1/163 ,  G06F1/3231 ,  G06F3/015 ,  G06F3/017 ,  G06F3/0346 ,  A61B5/11 ,  A61B5/681 ,  A61B5/6828 ,  A61B5/7455 ,  A61B2560/0276 ,  A61B2562/0219 ,  A61N2001/083

Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: a stimulator for electrically stimulating at least one nerve, a stimulator housing, a monitor for monitoring transient motion of the stimulator housing, an analyzer for analyzing transient motion monitored by the monitor for determining whether transient motion of the stimulator housing has occurred, and a controller for automatically transitioning at least one of the stimulator, the monitor, and the analyzer between a standby mode and a power save mode, wherein the power save mode supports a subset of the functionality of the stimulator and the monitor which is available in the standby mode so as to conserve battery power in the power save mode.

公开(公告)号：US11724100B2

公开(公告)日：2023-08-15

申请号：US17097884

申请日：2020-11-13

Applicant: Brent C. Reider

Inventor： Brent C. Reider

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/08

CPC classification number: A61N1/0452 ,  A61N1/0456 ,  A61N1/08 ,  A61N1/36031

Abstract: Systems and methods for forging neural pathways in a user include stimulation and biofeedback devices in electronic communication with a controller. EMG regulated stimulation may be triggered by the controller or by detection of embodied sensory responses from said body inducted by the controller visually or with electrostimulation to induce stress to create a period of heightened plasticity for the user's brain and to induce muscular contractions consistent with a desired movement of a portion of the users' body. Images to create stress or of the desired movement may be provided at an electronic display. Biofeedback may be received, and where determined to be positive, continued or increased stimulation may be provided. Where the biofeedback is determined to be negative, the stimulation may be decreased or stopped. The controller may process embodied sensory input from the user to learn the patient's emotional and physical thresholds.