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92 条记录 (耗时 0.019 秒)

    Compositions, methods, kits and apparatus for determining the presence or absence of protein component of telomerase enzyme
    12.
    发明授权
    Compositions, methods, kits and apparatus for determining the presence or absence of protein component of telomerase enzyme 失效
    用于确定端粒酶的蛋白质组分的存在或不存在的组合物，方法，试剂盒和装置

    公开(公告)号：US6037126A

    公开(公告)日：2000-03-14

    申请号：US873709

    申请日：1997-06-12

    申请人： Abraham Grossman

    发明人： Abraham Grossman

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/48 ,  C12Q1/6865 ,  G01N2333/91245

    摘要： The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in identification of protein component of human telomerase and measurement of its levels in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.

    摘要翻译： 本发明涉及用于鉴定和检测目标分析物的存在或不存在的方法，组合物，试剂盒和装置。 本发明的实施方案可用于鉴定人端粒酶的蛋白质组分和其在标本和样品中的水平的测量，以及用于实施这些方法的测试试剂盒和设备的设计。

    Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
    14.
    发明授权
    Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents 有权

    公开(公告)号：US11807892B2

    公开(公告)日：2023-11-07

    申请号：US16850895

    申请日：2020-04-16

    申请人： Nanobiosym, Inc.

    发明人： Anita Goel

    IPC分类号： C12Q1/00 ,  C12Q1/48

    CPC分类号： C12Q1/00 ,  C12Q1/48 ,  G01N2333/16 ,  G01N2333/91245 ,  G01N2500/02

    摘要： One aspect of the invention provides a system for drug discovery, drug development, drug screening, or drug validation. The system includes: a sample chamber comprising a target protein and a drug candidate that may interfere with the target protein in the sample chamber, wherein the sample chamber is configured to: detect one or more of the following: (a) interference between the drug candidate the target protein and/or (b) one or more dynamics of the drug candidate on the target protein, wherein the one or more dynamics comprise affinity of the drug candidate to the target protein, and select the drug candidate if one or more desirable dynamics is detected. The system includes one or more immobilized surfaces and is configured to detect interactions between the drug candidate and the target protein at the single-molecule level.

    Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
    16.
    发明授权
    Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents 有权

    公开(公告)号：US09862984B2

    公开(公告)日：2018-01-09

    申请号：US11790071

    申请日：2007-04-23

    申请人： Anita Goel

    发明人： Anita Goel

    IPC分类号： C12Q1/00 ,  C12Q1/48

    CPC分类号： C12Q1/00 ,  C12Q1/48 ,  G01N2333/16 ,  G01N2333/91245 ,  G01N2500/02

    摘要： The present application discloses methods and apparatuses for single molecule drug screening, discovery and validation. These methods and apparatuses allow a user to detect rapidly, using observation of single molecules, whether and how a drug candidate interferes with a target enzyme involved in a particular disease pathway. The methods and apparatuses described herein utilize single molecule manipulation and detection technologies (e.g., optical or magnetic tweezers) to directly detect whether the characteristic dynamics, or “mechanical signature,” of the target enzyme-substrate interaction are substantially altered or modulated by a drug candidate. Furthermore, the methods and apparatuses are useful for analyzing the modulation of the mechanical signature in order to identify potential interference mechanisms of a drug candidate. In one aspect of the invention, the methods and apparatuses disclosed herein relate to monitoring the real-time dynamic mechanical signatures of individual polymerase molecules (e.g. DNA polymerases, RNA polymerases, and reverse transcriptases) along a polynucleotide substrate in the presence of drug candidates that either inhibit or otherwise modulate the polymerization process. Identification and analysis of such drug candidates is critical for anti-viral, anti-cancer, and antibiotic drug development.

    Method for Identifying a Compound That Modulates Telomerase Activity
    20.
    发明申请
    Method for Identifying a Compound That Modulates Telomerase Activity 有权
    鉴定调节端粒酶活性的化合物的方法

    公开(公告)号：US20100216150A1

    公开(公告)日：2010-08-26

    申请号：US12701801

    申请日：2010-02-08

    申请人： Emmanuel Skordalakes

    发明人： Emmanuel Skordalakes

    IPC分类号： C12Q1/68 ,  G01N33/573

    CPC分类号： C12Q1/48 ,  G01N2333/91245

    摘要： The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase.

    摘要翻译： 本发明包括用于鉴定调节端粒酶活性的化合物的方法。 通过设计或筛选与TRBD，“拇指”，“手指”和/或“手掌”结构域的至少一个氨基酸残基结合的化合物来鉴定本发明化合物; 或FP-pocket，PT-pocket或Th-pocket端粒酶，并测试该化合物调节端粒酶活性的能力。