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    Method of operating a mass filter in mass spectrometry
    11.
    发明授权
    Method of operating a mass filter in mass spectrometry 有权
    在质谱中操作质量过滤器的方法

    公开(公告)号：US09543131B2

    公开(公告)日：2017-01-10

    申请号：US14180194

    申请日：2014-02-13

    申请人： Thermo Fisher Scientific (Bremen) GmbH

    发明人： Andreas Kuehn ,  Jan-Peter Hauschild ,  Dirk Nolting ,  Oliver Lange ,  Eugen Damoc

    IPC分类号： H01J49/02 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06

    CPC分类号： H01J49/0031 ,  H01J49/022 ,  H01J49/06 ,  H01J49/4215

    摘要： Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge ratio (m/z) filtering mode to transmit ions in one or more selected ranges of m/z to the discontinuous ion optical device; and operating the mass filter in a broad mass range mode transmitting ions of a mass range substantially wider than any mass range transmitted in the m/z filtering mode during one or more periods in which the discontinuous ion optical device is not processing ions from the mass filter. Utilization of this method assists to reduce contamination in the mass filter.

    摘要翻译： 本文公开了一种质谱法，其具有以下步骤：从离子源通过质量过滤器传输离子; 在质量过滤器下游的不连续离子光学装置中处理从质量过滤器接收的离子; 以质量/电荷比（m / z）滤波模式操作质量过滤器多个周期，以将m / z的一个或多个选定范围内的离子传输到不连续离子光学器件; 并且以广泛质量范围模式操作传质质量范围的离子，其质量范围比在m / z滤波模式下传输的任何质量范围宽的质量范围，其中不连续离子光学器件不处理离子的质量 过滤。 该方法的利用有助于减少质量过滤器中的污染。

    Ion detection
    13.
    发明授权
    Ion detection 有权
    离子检测

    公开(公告)号：US09496123B2

    公开(公告)日：2016-11-15

    申请号：US15161850

    申请日：2016-05-23

    申请人： Thermo Fisher Scientific (Bremen) GmbH

    发明人： Alexander Kholomeev ,  Alexander Alekseevich Makarov

    IPC分类号： H01J49/02

    CPC分类号： H01J49/025 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/425

    摘要： A mass analyzer in which ions form packets that oscillate with a period has an ion detector comprising: a detection arrangement; and compensation circuitry. The detection arrangement may comprise: a plurality of detection electrodes detecting image current signals from ions in the mass analyzer; and a preamplifier, providing an output based on the image current signals. The compensation circuitry provides a compensation signal to a respective compensatory part of the detection arrangement, based on one or more of the image current signals. A capacitance between each of the compensatory parts of the detection arrangement and a signal-carrying part of the detection arrangement affects the signal-to-noise ratio of the preamplifier output. A generator may provide a trapping field defining an ion trapping volume and a shielding conductor may be positioned between two detection electrodes, with a controller applying a voltage to the shielding conductor based on a detected image current.

    摘要翻译： 其中离子形成具有一段时间振荡的分组的质量分析器具有离子检测器，其包括：检测装置; 和补偿电路。 检测装置可以包括：多个检测电极，用于检测质量分析器中离子的图像电流信号; 和前置放大器，基于图像电流信号提供输出。 补偿电路基于一个或多个图像电流信号向检测装置的相应的补偿部分提供补偿信号。 检测装置的每个补偿部分和检测装置的信号承载部分之间的电容影响前置放大器输出的信噪比。 发生器可以提供限定离子捕获体积的捕获场，并且屏蔽导体可以位于两个检测电极之间，其中控制器基于检测到的图像电流向屏蔽导体施加电压。

    High voltage power supply filter for a mass spectrometer
    15.
    发明授权
    High voltage power supply filter for a mass spectrometer 有权
    用于质谱仪的高压电源滤波器

    公开(公告)号：US09437409B2

    公开(公告)日：2016-09-06

    申请号：US14367229

    申请日：2012-12-06

    申请人： DH Technologies Development Pte. Ltd.

    发明人： John Vandermey ,  Alexander Tsipirovich

    IPC分类号： H02M7/10 ,  H03H7/01 ,  H03H11/04 ,  H01J49/02 ,  G05F3/16 ,  H01J49/06 ,  H01J49/26

    CPC分类号： H01J49/022 ,  G05F3/16 ,  H01J49/025 ,  H01J49/067 ,  H01J49/26 ,  H03H7/0138 ,  H03H11/04

    摘要： Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises at least one component that operates at a high voltage. A number of high voltage filters or circuits are provided for reducing noise from high voltage power supplies that produce positive and negative voltages. In some embodiments, the filters can comprise one or more diodes. In some embodiments, the filters can comprise one or more transistors. In some embodiments, the filters can comprise one or more transistor pairs. A variety of embodiments of systems, devices, circuits, and methods in conjunction with the disclosures are provided.

    摘要翻译： 提供了用于改进的质谱检测系统的系统，装置，电路和方法，所述质谱检测系统包括在高电压下工作的至少一个组件。 提供了许多高压滤波器或电路，用于降低产生正负电压的高压电源的噪声。 在一些实施例中，滤波器可以包括一个或多个二极管。 在一些实施例中，滤波器可以包括一个或多个晶体管。 在一些实施例中，滤波器可以包括一个或多个晶体管对。 提供了结合公开的系统，设备，电路和方法的各种实施例。

    Calibrating dual ADC acquisition system
    17.
    发明授权
    Calibrating dual ADC acquisition system 有权
    校准双ADC采集系统

    公开(公告)号：US09324545B2

    公开(公告)日：2016-04-26

    申请号：US14401738

    申请日：2013-05-16

    申请人： Micromass UK Limited

    发明人： Martin Raymond Green ,  Jason Lee Wildgoose

    IPC分类号： H01J49/40 ,  H01J49/02 ,  H01J49/00 ,  G01N30/72 ,  H03M1/18 ,  H03M1/08

    CPC分类号： H01J49/022 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/025 ,  H03M1/0836 ,  H03M1/188

    摘要： A method of calibrating a dual gain ADC detector system is disclosed comprising passing a test signal through a high gain signal path to produce a first signal and passing a test signal through a low gain signal path to produce a second signal. A time difference between the first signal and the second signal is then determined. Data from the two ADCs is then stitched to form a composite mass spectrum without needing to correct the phase between the two ADCs.

    摘要翻译： 公开了一种校准双增益ADC检测器系统的方法，其包括使测试信号通过高增益信号路径以产生第一信号并使测试信号通过低增益信号路径以产生第二信号。 然后确定第一信号和第二信号之间的时间差。 然后将来自两个ADC的数据进行缝合以形成复合质谱，而不需要校正两个ADC之间的相位。

    Methods, apparatus, and system for mass spectrometry
    18.
    发明授权
    Methods, apparatus, and system for mass spectrometry 有权
    方法，仪器和质谱系统

    公开(公告)号：US09312117B2

    公开(公告)日：2016-04-12

    申请号：US14268599

    申请日：2014-05-02

    申请人： Massachusetts Institute of Technology

    发明人： Ian W. Hunter ,  Brian Hemond ,  Harold F. Hemond

    IPC分类号： H01J49/04 ,  H01J49/22 ,  H01J49/30 ,  H01J49/00 ,  H01J49/14 ,  H01J49/02 ,  H01J49/24

    CPC分类号： H01J49/30 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/147 ,  H01J49/24

    摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.

    摘要翻译： 一种小型，低成本的质谱仪，能够在10至50 AMU的质量范围内进行单位分辨率。 质谱仪结合了几个功能，可以提高设计的性能，而不是可比较的仪器。 高效的离子源能够在不牺牲测量分辨率的情况下实现相对较低的功耗。 可变几何机械滤镜允许可变分辨率。 机载离子泵不需要外部泵浦源。 磁轭和磁轭产生具有不同磁通密度的磁场区域以运行离子泵和磁性扇区质量分析器。 真空室内的数字控制器和电源转换电路允许在质谱仪的操作上具有很大的灵活性，同时不需要高压电气馈通。 微型质谱仪感测入口气体百分比的分数，并将质谱数据返回到计算机。

    Capacitive transimpedance amplifier with offset
    20.
    发明授权
    Capacitive transimpedance amplifier with offset 有权
    带偏移的电容跨阻放大器

    公开(公告)号：US09228979B2

    公开(公告)日：2016-01-05

    申请号：US14401277

    申请日：2013-05-31

    申请人： Smiths Detection-Watford Limited

    发明人： John Patrick Fitzgerald

    IPC分类号： H01J49/02 ,  H03F1/08 ,  G01N27/62 ,  H03F3/70

    CPC分类号： G01N27/622 ,  H01J49/022 ,  H03F3/70 ,  H03F2200/267

    摘要： Spectrometers including integrated capacitive detectors are described. An integrated capacitive detector integrates ion current from the collector (768) into a changing voltage. The detector includes a collector configured to receive ions in the spectrometer, a dielectric, and a plate arranged in an overlapping configuration with collector on an opposite side of the dielectric. The detector also includes an amplifier (764). A capacitive detector with offset (776) is described.

    摘要翻译： 描述了包含集成电容式检测器的光谱仪。 集成电容检测器将来自集电极（768）的离子电流集成到变化的电压中。 检测器包括被配置为在光谱仪中接收离子的集电体，电介质和布置成与电介质的相对侧上的集电极重叠配置的板。 检测器还包括放大器（764）。 描述了具有偏移（776）的电容式检测器。