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公开(公告)号：US20160256868A1
公开(公告)日：2016-09-08
申请号：US15159405
申请日：2016-05-19
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Luis ORTIZ-HERNANDEZ , Kenneth DAVENPORT
CPC classification number: B01L3/502 , B01L3/505 , B01L3/508 , B01L2200/026 , B01L2300/046 , B01L2300/049 , B01L2300/0609 , B01L2300/08 , B01L2300/123 , B01L2400/0481 , B01L2400/06 , B65D25/38 , B65D77/06
Abstract: A valve assembly for use with a flexible container, in which the valve assembly is anchored to the flexible container. The valve assembly provides for the egress of fluid from the flexible container such that the interior surfaces flexible container do not block or otherwise prevent fluid flow or fluidic communication between the interior of the flexible container and the valve assembly. The portion of the valve assembly within the interior of the flexible container includes a support structure that prevents the walls of the flexible container from collapsing down on, and blocking either completely or in part, fluid flow through the opening of the valve inside of the flexible container.
Abstract translation: 一种与柔性容器一起使用的阀组件，其中阀组件固定在柔性容器上。 阀组件提供了来自柔性容器的流体的出口，使得内表面柔性容器不阻挡或以其它方式阻止柔性容器的内部与阀组件之间的流体流动或流体连通。 阀组件在柔性容器内部的部分包括支撑结构，该支撑结构防止柔性容器的壁塌陷，并且完全或部分地阻止通过柔性容器内部的阀的开口的流体流动 容器。
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192.发明申请CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE 审中-公开1,4,7-三唑烷酮的结合物，这种共轭物的金属络合物，以及1,4,7-三唑并噻吩并联体的使用方法公开(公告)号：US20160223491A1
公开(公告)日：2016-08-04
申请号：US15015415
申请日：2016-02-04
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Thomas R. Berkelman , Lisandra Martin , Rhiannon Jones , John Walker, II
IPC: G01N27/447 , G01N33/543 , C07F3/06 , C07F13/00 , C08F220/56 , C07D255/02
CPC classification number: G01N27/44747 , B01D15/3823 , C07D255/02 , C07F3/06 , C07F13/005 , C08F220/56 , C08F220/60 , G01N33/54306 , Y10T436/143333 , Y10T436/163333
Abstract: Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications. In addition, dinuclear metal complexes of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes that are not so conjugated are used in the detection of phosphate esters of biological species by either MALDI-TOF mass spectrometry or by dye displacement.
Abstract translation: 将1,3-双（1,4,7-三氮杂环壬-1-烯）-2-羟基丙烷与多种共轭成员的共轭物用于形成与磷酸酯结合的双核金属络合物。 由于它们的共轭形式，复合物被并入到色谱介质，亲和力结合试剂和染料中，这使复合物可用于广泛的测定，分离和纯化。 此外，不结合的1,3-双（1,4,7-三氮杂环壬烷-1-基）-2-羟基丙烷的双核金属络合物用于通过MALDI-TOF检测生物物种的磷酸酯 质谱或染料置换。
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公开(公告)号：US09403294B2
公开(公告)日：2016-08-02
申请号：US14255892
申请日：2014-04-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Thomas H. Cauley, III
CPC classification number: B29C33/3842 , B01F3/0807 , B01F3/0861 , B01F13/0062 , B01F15/0238 , B01F15/0258 , B01L3/00 , B01L3/502707 , B01L3/502784 , B01L2200/0673 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B29C33/3835 , B29C33/42 , Y10T29/49764 , Y10T29/49771 , Y10T29/49982 , Y10T29/49989 , Y10T29/49998
Abstract: Method of making a droplet-generating device. In the method, a first droplet-generating device may be produced. The first droplet-generating device may include a molded portion created at least in part with a mold and also may include a plurality of droplet generators each formed at least in part by the molded portion. A set of droplets may be generated with each of one or more of the droplet generators. A property of at least one set of generated droplets may be determined. The mold may be modified based on the property. A second droplet-generating device may be produced that includes a molded portion created at least in part with the modified mold.
Abstract translation: 制造液滴生成装置的方法。 在该方法中，可以制造第一液滴产生装置。 第一液滴产生装置可以包括至少部分地由模具形成的模制部分，并且还可以包括多个液滴发生器，每个液滴发生器至少部分地由模制部分形成。 可以用一个或多个液滴发生器中的每一个产生一组液滴。 可以确定至少一组产生的液滴的性质。 模具可以根据性能进行修改。 可以制造第二液滴产生装置，其包括至少部分地由改性模具形成的模制部分。
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公开(公告)号：US20160208319A1
公开(公告)日：2016-07-21
申请号：US14991818
申请日：2016-01-08
Applicant: Bio-Rad Laboratories, Inc. , J. David Gladstone Institutes
Inventor： Jennifer Berman , Samantha Cooper , George Karlin-Neumann , Yuichiro Miyaoka , Bruce Conklin , Josh Shinoff
IPC: C12Q1/68
CPC classification number: C12Q1/6827 , C12N15/102 , C12N15/63 , C12Q1/6809 , C12Q2537/143 , C12Q2563/159 , C12Q2565/101
Abstract: Methods, compositions, and kits are provided for quantification of genome editing.
Abstract translation: 提供方法，组合物和试剂盒用于定量基因组编辑。
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公开(公告)号：US09388945B2
公开(公告)日：2016-07-12
申请号：US14170875
申请日：2014-02-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Adam Bemis , Thomas H. Cauley, III , Klint Rose , James M. Hamilton
CPC classification number: F17D3/00 , B01F5/0068 , B01F5/0071 , B01F5/0074 , B01F2009/0092 , B01F2009/0094 , B01F2009/0098 , B01L3/0275 , B01L3/0279 , B01L3/502784 , B01L3/5085 , B01L2200/0684 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0867 , Y10T137/86083
Abstract: System, including apparatus and methods, for aspirating at least a portion of an emulsion from a well using a tip. In some embodiments, the tip may have a flat end and an inlet surrounded by the flat end. The well may have a floor with one or more surface features that prevent uninterrupted circumferential contact of the flat end of the tip with any region of the floor. In some embodiments, the tip may not have a flat end. In some embodiments, the well may have a port that guides the tip to the floor with the tip slanted with respect to the floor. Methods of making a device that includes the well are also disclosed.
Abstract translation: 用于使用尖端从井抽出至少一部分乳液的系统，包括装置和方法。 在一些实施例中，尖端可以具有平坦端部和由平坦端部包围的入口。 井可以具有一个或多个表面特征的地板，其防止尖端的平坦端与地板的任何区域的不间断的圆周接触。 在一些实施例中，尖端可以不具有平坦端。 在一些实施例中，井可以具有将尖端引导到地板的端口，其中尖端相对于地板倾斜。 还公开了制造包括井的装置的方法。
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Patent Agency Ranking
公开(公告)号：US09358542B2
公开(公告)日：2016-06-07
申请号：US14317969
申请日：2014-06-27
Applicant: Bio-Rad Laboratories, Inc. , BioCanal
Inventor： Amandeep Tyagi , James Xu , Shengjue Lu , Haihui Yuan
CPC classification number: B01L9/06 , B01L2200/02 , B01L2200/025 , B01L2200/0647 , B01L2300/042 , B01L2300/0851 , B01L2400/043 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , B66F11/00
Abstract: A system for holding sample tubes used in immunoprecipitation and similar laboratory techniques. A rack comprises top and bottom plates spaced apart from each other and defining rows of holes to receive the sample tubes and hold the sample tubes in a pair of spaced-apart rows. A magnet holder is configured to slide between the top and bottom plates and between the two parallel rows of sample tubes such that when the magnet holder is fully inserted between the rows of sample tubes, magnets held by the magnet holder align with the sample tubes in the two parallel rows.
Abstract translation: 用于保存用于免疫沉淀和类似实验室技术的样品管的系统。 机架包括彼此间隔开的顶板和底板，并且限定一排孔以接收样品管并将样品管保持在一对间隔开的行中。 磁体保持器构造成在顶板和底板之间以及在两排平行的样品管之间滑动，使得当磁体保持器完全插入样品管排之间时，由磁体保持器固定的磁体与样品管对准 两行平行。
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公开(公告)号：US09347094B2
公开(公告)日：2016-05-24
申请号：US14171393
申请日：2014-02-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Claudia Litterst , Luis A. Ugozzoli
IPC: C12Q1/68
CPC classification number: C12Q1/6858 , C12Q1/6844 , C12Q2537/16 , C12Q2563/159
Abstract: A method of characterizing telomere length. A template may be synthesized in a bulk phase reaction mixture containing genomic DNA. Partitions may be formed after synthesizing the template in the bulk phase reaction mixture, with only a subset of the partitions containing at least one copy of the template. At least a region of the template may be amplified in partitions. Amplification data may be collected from partitions. A measure of telomere length may be determined for the genomic DNA based on the amplification data. In some embodiments, the bulk phase reaction mixture may be thermally cycled for at least two cycles, and heated to a denaturation temperature and cooled to an annealing temperature in each cycle.
Abstract translation: 一种表征端粒长度的方法。 可以在含有基因组DNA的本体相反应混合物中合成模板。 在本体相反应混合物中合成模板之后可以形成分隔，只有分区的一个子集包含至少一个模板副本。 模板的至少一个区域可以在分区中被放大。 可以从分区收集扩增数据。 可以基于扩增数据确定基因组DNA的端粒长度的量度。 在一些实施方案中，本体相反应混合物可以热循环至少两个循环，并加热至变性温度并在每个循环中冷却至退火温度。
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公开(公告)号：US09322002B2
公开(公告)日：2016-04-26
申请号：US14186030
申请日：2014-02-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng
CPC classification number: C12N9/1241 , C07K2319/80 , C12N9/1252 , C12N9/96 , C12Q1/686
Abstract: Improved Sso7-polymerase conjugate proteins are provided.
Abstract translation: 提供了改进的Sso7聚合酶缀合蛋白。
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公开(公告)号：US09320988B2
公开(公告)日：2016-04-26
申请号：US14209974
申请日：2014-03-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Wrench , William Mainwaring-Burton
IPC: B01D19/00
CPC classification number: B01D19/0031
Abstract: Disclosed herein is an apparatus for debubbling or degassing a liquid. The apparatus includes a tube with a hollow lumen and a gas-permeable, liquid-impermeable wall surrounding the lumen. Also disclosed is a method for performing the debubbling or degassing, wherein the liquid is passed through the tube and gas is allowed to escape through the wall of the tube. The application additionally discloses a system for debubbling or degassing a liquid, wherein a pump is connected to the upstream end of the tube and a device to impede the flow of liquid out the tube is connected to the downstream end.
Abstract translation: 本文公开了一种用于对液体进行脱泡或脱气的装置。 该装置包括具有中空腔的管和围绕腔的透气的液体不可渗透的壁。 还公开了一种用于进行脱泡或脱气的方法，其中液体通过管，并且允许气体通过管的壁逸出。 该应用还公开了一种用于对液体进行脱泡或脱气的系统，其中泵连接到管的上游端，并且阻止液体流出管的装置连接到下游端。
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公开(公告)号：US20160053305A1
公开(公告)日：2016-02-25
申请号：US14828242
申请日：2015-08-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng , Xiao-Song Gong , Yan Wang , Adam M. McCoy
CPC classification number: C12Q1/6806 , C12P19/34 , C12Q1/6853 , C12Q1/686 , C12Q2521/107 , C12Q2521/131 , C12Q2521/327 , C12Q2525/207 , C12Q2525/121
Abstract: Methods of detecting and amplifying short RNAs are provided.
Abstract translation: 提供了检测和扩增短RNA的方法。
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