公开(公告)号：US20170275280A1

公开(公告)日：2017-09-28

申请号：US15505260

申请日：2015-08-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Cara B. GONZALES ,  Stanton McHARDY

IPC: C07D471/04 ,  A61K31/55 ,  C07D223/16 ,  A61K31/472 ,  C07D217/06 ,  A61K31/4035 ,  C07D209/44 ,  A61K31/5377 ,  C07D213/68 ,  A61K31/4745 ,  A61K31/17 ,  C07C335/12 ,  C07C275/24 ,  A61K31/165 ,  C07C233/29 ,  A61K31/155

CPC classification number: C07D471/04 ,  A61K31/155 ,  A61K31/165 ,  A61K31/17 ,  A61K31/4035 ,  A61K31/472 ,  A61K31/4745 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  C07C211/29 ,  C07C233/29 ,  C07C275/24 ,  C07C335/12 ,  C07D209/44 ,  C07D213/68 ,  C07D217/06 ,  C07D223/16 ,  A61K2300/00

Abstract: The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be used to treating include but are not limited to breast, cervical, oral, head, neck, or prostate cancer. In some aspects, the compounds may be useful in treating a tumor by direct injection of the compound into the tumor, particularly an oral tumor. In other aspects, the compounds are administered systemically. The compounds of the present disclosure may also be used to treat the pain associated with a tumor for which it is being administered.

公开(公告)号：US09751970B2

公开(公告)日：2017-09-05

申请号：US15072522

申请日：2016-03-17

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K8/00 ,  C08F293/00 ,  C07D311/92 ,  A61K9/127 ,  A61K47/48 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K31/352 ,  A61K9/107 ,  A61K49/00 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20170216323A1

公开(公告)日：2017-08-03

申请号：US15474443

申请日：2017-03-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Antonella Casola ,  Roberto P. Garofalo

IPC: A61K31/675 ,  A61K9/00

CPC classification number: A61K31/675 ,  A61K9/0073 ,  A61K31/10 ,  A61K31/385 ,  A61K31/404 ,  A61K31/5375 ,  A61K33/04 ,  A61K45/06 ,  A61K2300/00

Abstract: Certain embodiments are directed to methods of treating respiratory infection by administering an H2S donor.

公开(公告)号：US20170211050A1

公开(公告)日：2017-07-27

申请号：US15127617

申请日：2015-03-20

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Andrew D. Ellington ,  Adam J. Meyer

IPC: C12N9/12 ,  C12N15/115 ,  C12N15/11 ,  C12P19/34

CPC classification number: C12N9/1247 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2320/51 ,  C12N2330/00 ,  C12N2330/51 ,  C12P19/34 ,  C12Y207/07006

Abstract: Disclosed are T7 RNA polymerase variants with enhanced transcriptional activity. T7 RNA polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing RNA molecules. However, these variants have relatively low levels of transcriptional activity. Presented herein are mutations that increase the transcriptional activity of the variants with broad substrate range.

公开(公告)号：US09649344B2

公开(公告)日：2017-05-16

申请号：US14418957

申请日：2013-07-31

Applicant: The Board of Regents of the University of Texas System

Inventor： Bruno Doiron ,  Ralph A. DeFronzo

IPC: A61K35/39 ,  A61K31/7088 ,  A61K38/17 ,  A61K38/45 ,  C12N15/113 ,  C07K14/47 ,  C12N9/12 ,  C12N9/16 ,  A61K48/00

CPC classification number: A61K35/39 ,  A61K31/7088 ,  A61K38/1709 ,  A61K38/45 ,  A61K48/00 ,  C07K14/4702 ,  C12N9/1205 ,  C12N9/16 ,  C12N15/1137 ,  C12N2320/31 ,  C12N2330/51 ,  C12N2740/15043 ,  C12Y207/01002 ,  C12Y301/03048 ,  C12N2310/14 ,  C12N2310/531

Abstract: Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes. In certain aspects, the methods include the integration of three levels of cellular physiology: metabolism, membrane receptor function, and gene transcription. The integration of multiple levels of cellular physiology produces a synergistic effect on beta cell formation.

公开(公告)号：US09642859B2

公开(公告)日：2017-05-09

申请号：US14649272

申请日：2013-12-03

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Cara B. Gonzales

IPC: A61K31/55 ,  A61K9/19 ,  A61K45/06 ,  A61P35/00 ,  A61K9/00

CPC classification number: A61K31/55 ,  A61K9/0019 ,  A61K45/06

Abstract: Disclosed are methods and compositions for treating cancer, particularly for reducing cancerous cell growth, for example, in solid tumors. Disclosed methods and compositions include capsazepine (CPZ) or an analog of CPZ. Compositions comprising CPZ or an analog of CPZ may be useful for simultaneously treating cancer and alleviating pain by blocking TRPV1 channels.

公开(公告)号：US09616076B2

公开(公告)日：2017-04-11

申请号：US14728737

申请日：2015-06-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Antonella Casola ,  Roberto P. Garofalo

IPC: A61K31/10 ,  A61K31/675 ,  A61K45/06 ,  A61K31/385 ,  A61K31/404 ,  A61K31/5375 ,  A61K33/04

CPC classification number: A61K31/675 ,  A61K9/0073 ,  A61K31/10 ,  A61K31/385 ,  A61K31/404 ,  A61K31/5375 ,  A61K33/04 ,  A61K45/06 ,  A61K2300/00

Abstract: Certain embodiments are directed to methods of treating respiratory infection by administering an H2S donor.

公开(公告)号：US09611266B2

公开(公告)日：2017-04-04

申请号：US14993029

申请日：2016-01-11

Applicant: The Board of Trustees of the University of Illinois ,  The Board of Regents of the University of Texas System

Inventor： Paul J. Hergenrother ,  David A. Boothman ,  Joseph S. Bair ,  Rahul Palchaudhuri ,  Elizabeth I. Parkinson

IPC: A61K31/675 ,  C07D471/00 ,  C07D471/04 ,  A61K31/47 ,  C07H15/26 ,  C07F9/6561

CPC classification number: A61K31/4745 ,  A61K31/47 ,  A61K45/06 ,  C07D471/04 ,  C07F9/6561 ,  C07H15/26

Abstract: Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.

公开(公告)号：US20170085367A1

公开(公告)日：2017-03-23

申请号：US15087422

申请日：2016-03-31

Applicant: The Board of Regents of The University of Texas System

Inventor： Benito R. Fernández ,  José R. Capriles-Grané ,  Michael D. Bryant ,  John W. Hall ,  Carlos A. García

IPC: H04L9/00 ,  H03K3/84

CPC classification number: H04L9/001 ,  G06F1/04 ,  H03B5/1259 ,  H03B28/00 ,  H03B29/00 ,  H03K3/84 ,  H04L2209/12

Abstract: Described herein is a combination of mixed-signal hardware and software that is capable or realizing hybrid chaotic oscillators that can be tuned digitally. This includes the type/class of chaotic oscillator, initial conditions, nonlinear elements, thresholds, nonlinear event surfaces, delays, etc. At the same time, tunable methods of how to use the chaotic oscillator information to encrypt and decrypt both analog and digital information is presented. This will make the secure information not vulnerable by digital information compromises or hardware breach.

公开(公告)号：US20170056557A1

公开(公告)日：2017-03-02

申请号：US15118539

申请日：2015-02-09

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Xiao-Dong Chen ,  Chih-ko Yeh ,  Joo L. Ong

IPC: A61L27/36 ,  A61L27/38 ,  G01N33/50 ,  C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0633 ,  A61L27/227 ,  A61L27/3813 ,  C12N2501/999 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/56

Abstract: A cell culture system including a silk fibroid scaffold, culture media, and salivary gland cells. The salivary gland cells grown in the tissue culture system have physiological and morphological features like those of in vivo salivary gland cells. The cell culture system can be used to produce a salivary tissue-specific extracellular matrix capable of inducing differentiation of salivary gland cell precursors into salivary gland cells.

Abstract translation: 包括丝纤维支架，培养基和唾液腺细胞的细胞培养系统。 在组织培养系统中生长的唾液腺细胞具有生物学和形态特征，如体内唾液腺细胞。 细胞培养系统可用于产生能够诱导唾液腺细胞前体分化为唾液腺细胞的唾液组织特异性细胞外基质。