公开(公告)号：US20240269270A1

公开(公告)日：2024-08-15

申请号：US18042637

申请日：2021-08-23

Applicant: SANOFI PASTEUR INC. ,  GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Natalie ANOSOVA ,  Salvador Fernando AUSAR ,  Catherine BERRY ,  Florence BOUDET ,  Thomas BREUER ,  Danilo CASIMIRO ,  Roman M. CHICZ ,  Gustavo DAYAN ,  Guy DE BRUYN ,  Carlos DIAZGRANADOS ,  Tong-Ming FU ,  Marie GARINOT ,  Lorry GRADY ,  Sanjay GURUNATHAN ,  Kirill KALNIN ,  Nikolai KHRAMTSOV ,  Valérie LECOUTURIER ,  Nausheen RAHMAN ,  Sophie RUIZ ,  Stephen SAVARINO ,  Saranya SRIDHAR ,  Indresh K. SRIVASTAVA ,  James TARTAGLIA ,  Timothy TIBBITTS

IPC: A61K39/39 ,  A61K39/00 ,  A61K39/215 ,  A61P37/04 ,  C07K14/005 ,  C12N5/07 ,  C12N7/00

CPC classification number: A61K39/39 ,  A61K39/215 ,  A61P37/04 ,  C07K14/005 ,  C12N5/0601 ,  C12N7/00 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071

Abstract: Provided are novel vaccines for prophylactic treatment of SARS-COV-2 infections and COVID-19 and methods of making the vaccines, wherein the vaccines contain an oil-in-water emulsion comprising tocopherol and squalene.

公开(公告)号：US20240228551A9

公开(公告)日：2024-07-11

申请号：US18328162

申请日：2023-06-02

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Maria SCARSELLI ,  Daniele VEGGI

IPC: C07K14/22 ,  A61K39/095 ,  A61P31/04

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61P31/04 ,  C07K2319/00

Abstract: The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.

公开(公告)号：US20240218026A1

公开(公告)日：2024-07-04

申请号：US18440212

申请日：2024-02-13

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew BOTTOMLEY ,  Enrico MALITO ,  Manuele MARTINELLI ,  Maria SCARSELLI

IPC: C07K14/22 ,  A61K39/095 ,  A61K39/00

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US20240189417A1

公开(公告)日：2024-06-13

申请号：US18425426

申请日：2024-01-29

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Giulietta MARUGGI ,  Qiongman KONG ,  Varnika ROY ,  Dong YU ,  Meng ZHANG

IPC: A61K39/215 ,  A61K39/00 ,  A61K39/02 ,  A61P31/14 ,  A61P37/04 ,  C12P19/34

CPC classification number: A61K39/215 ,  A61K39/0002 ,  A61K39/0011 ,  A61K39/0013 ,  A61K39/02 ,  A61P31/14 ,  A61P37/04 ,  C12P19/34 ,  A61K2039/53

Abstract: Provided herein are RNA that: are collectively self-amplifying in an intracellular environment, comprise N1-methyl-pseudouridines and uridines, and have a mole percentage or mole proportion of the N1-methylpseudouridines to the total of the uridines and the Ni-methylpseudouridines or a mole ration of the N1-methylpseudouridines to the uridines.

公开(公告)号：US20240115688A1

公开(公告)日：2024-04-11

申请号：US18255442

申请日：2021-11-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Roberta COZZI ,  Adele FANTONI ,  Sanjay PHOGAT ,  Roberto ROSINI ,  Maria SCARSELLI ,  Newton WAHOME

IPC: A61K39/12 ,  C07K14/005 ,  C07K14/245

CPC classification number: A61K39/12 ,  C07K14/005 ,  C07K14/245 ,  A61K2039/55572

Abstract: The present invention is directed to novel, modified FimH polypeptides, nucleic acids encoding them, and the use of the polypeptides and nucleic acids in the treatment and/or prevention of disease, in particular, urinary tract infection (UTI).

公开(公告)号：US20240115501A1

公开(公告)日：2024-04-11

申请号：US18508435

申请日：2023-11-14

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Andrew GEALL

IPC: A61K9/127 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/12 ,  C12N15/86

CPC classification number: A61K9/127 ,  A61K9/1272 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/12 ,  C12N15/86 ,  A61K39/39 ,  A61K2039/55555 ,  C12N2760/18534

Abstract: RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. hese liposomes can have essentially a neutral surface charge at physiological pH and are effective for immunisation.

公开(公告)号：US20240100140A1

公开(公告)日：2024-03-28

申请号：US18131557

申请日：2023-04-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza FARIDMOAYER ,  Rainer FOLLADOR ,  Stefan Jochen KEMMLER ,  Michael Thomas KOWARIK ,  Gerd Martin LIPOWSKY ,  Gerald Johann POSCH ,  Fabio SERVENTI

IPC: A61K39/09 ,  C12P19/04 ,  C12P21/00

CPC classification number: A61K39/092 ,  C12P19/04 ,  C12P21/005

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

公开(公告)号：US20240093161A1

公开(公告)日：2024-03-21

申请号：US18453078

申请日：2023-08-21

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA

IPC: C12N7/00 ,  A61K39/235 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K39/235 ,  C12N15/86 ,  A61K2039/5256

Abstract: A simian adenoviral vector comprising two expression cassettes, wherein each expression cassette comprises a transgene and a promoter, and wherein the first expression cassette is inserted in the E1 region of the simian adenoviral vector, and the second expression cassette is inserted in a region of the adenoviral vector that is compatible with vector replication.

公开(公告)号：US11932669B2

公开(公告)日：2024-03-19

申请号：US17223207

申请日：2021-04-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico Malito ,  Matthew James Bottomley ,  Andrea Carfi ,  Sumana Chandramouli ,  Kate Luisi

IPC: C07K14/045 ,  A61K38/00 ,  A61K39/245

CPC classification number: C07K14/045 ,  A61K39/245 ,  A61K38/00

Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.

公开(公告)号：US20240075125A1

公开(公告)日：2024-03-07

申请号：US18200421

申请日：2023-05-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Alessandra Vitelli ,  Alfredo Nicosia ,  Riccardo Cortese

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  C12N15/85 ,  C12N15/86

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  C12N15/85 ,  C12N15/86 ,  A61K2039/53

Abstract: The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a T cell response, and a second polynucleotide encoding at least one protein, peptide or variant thereof, which induces an anti-pathogenic B cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture.