-
231.发明申请公开(公告)号：US20170336423A1
公开(公告)日：2017-11-23
申请号：US15524095
申请日：2015-11-05
Inventor： Michael P. Chapman , Hunter B. Moore , Eduardo Gonzalez Barreda , Ernest E. Moore
CPC classification number: G01N33/86 , A61K38/36 , C12Q1/56 , G01N2800/224 , G01N2800/226
Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis. In some embodiments, the invention also provides a container adapted for detecting an aberrant fibrinolysis condition in a blood sample using viscoelastic analysis comprising an interior having a coating comprising a thrombolytic agent.
-
232.发明申请公开(公告)号：US20170292073A1
公开(公告)日：2017-10-12
申请号：US15512793
申请日：2015-09-22
Inventor： Quingkun Liu , Ivan Smalyukh
IPC: C09K19/22
CPC classification number: C09K19/22 , C09K2019/122 , C09K2019/3009 , C09K2019/521
Abstract: Disclosed herein are compositions, comprising one or more types of surface modified anisotropic nanoparticles dispersed in a liquid crystal. The compositions provide tunable methods for modifying light and energy flow.
-
公开(公告)号：US09767940B2
公开(公告)日：2017-09-19
申请号：US14580103
申请日：2014-12-22
Inventor： Daniel Cornelis van der Laan
CPC classification number: H01B12/08 , H01L39/143 , H01L39/18 , H01L39/2419 , H01L39/248 , Y10T29/49014
Abstract: Superconducting cables employ one or more superconducting tapes wound around a former. A compact superconducting cable is configured using a former having a small diameter, e.g., less than 10 millimeters. A flexible superconducting cable is configured with a former made of a flexible material. Superconducting tape conductors are wound around the former, with the superconducting layer in compression on the inside of the wind turns of the wind, to prevent irreversible damage to the superconductor. A layer of solder is on the superconducting tape(s) or solder sheaths are wound between tape conductors in each layer. The one or more solder layers or sheaths are melted to cause the solder to flow within the structure, to bond some or all of the superconducting tape conductors together and form a mechanically strong cable with an enhanced level of electrical connectivity between tapes in the cable.
-
公开(公告)号：US20170260589A1
公开(公告)日：2017-09-14
申请号：US15335378
申请日：2016-10-26
Applicant: Loxo Oncology, Inc. , The Regents of the University of Colorado, a body corporate , Array BioPharma, Inc.
Inventor： Nisha Nanda , Josh H. Bilenker , Robert C. Doebele , James F. Blake , Gabrielle R. Kolakowski , Barbara J. Brandhuber , Steven W. Andrews
IPC: C12Q1/68 , A61K31/519 , A61K31/5025
Abstract: Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment that does not include a Trk inhibitor, methods of determining the likelihood that a subject having a cancer will have a positive response to a treatment with a Trk inhibitor, methods of predicting the efficacy of a Trk inhibitor in a subject having cancer, methods of determining a subject's risk for developing a Trk inhibitor-resistant cancer, and methods of determining the presence of a Trk inhibitor-resistant cancer in a subject, based on the detection of a cell from a sample from the subject that has at least one of the the point mutations in NTRK1 and/or NTRK2 and/or NTRK3.
-
公开(公告)号：US20170248381A1
公开(公告)日：2017-08-31
申请号：US15056680
申请日：2016-02-29
Inventor： Ronggui YANG , Xiaobo YIN , Gang TAN , Dongliang ZHAO , Yaoguang MA , Yao ZHAI
CPC classification number: F28F13/18 , B32B27/32 , B32B27/36 , B32B2255/10 , B32B2255/205 , B32B2264/102 , B32B2307/416 , F28F21/067 , F28F2245/06
Abstract: Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.
-
Patent Agency Ranking
公开(公告)号：US20170232143A1
公开(公告)日：2017-08-17
申请号：US15409392
申请日：2017-01-18
Inventor： Kristi ANSETH , Ben FAIRBANKS , Christopher BOWMAN
CPC classification number: A61L27/18 , A61L27/22 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C08F38/00 , C08G75/045 , C08G75/12 , C08J3/075 , C08J2300/16 , C08J2300/20 , C08J2371/02 , C08L81/02 , C08L101/02 , C08L101/16 , C12N5/0068
Abstract: A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers.
-
公开(公告)号：US09731045B2
公开(公告)日：2017-08-15
申请号：US14148617
申请日：2014-01-06
Inventor： Kenneth Gall , Christopher Yakacki
CPC classification number: A61L27/16 , A61B17/0401 , A61B2017/00871 , A61B2017/0448 , A61F2/0811 , A61F2002/0835 , A61F2002/0858 , A61F2002/0864 , A61F2002/0882 , A61F2002/0888 , A61F2210/0014 , A61L27/50 , A61L2400/16 , A61L2430/02
Abstract: A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation.
-
公开(公告)号：US20170202487A1
公开(公告)日：2017-07-20
申请号：US15302142
申请日：2015-05-04
Inventor： Justin CASEY
CPC classification number: A61B5/125 , A61B5/1126 , A61B5/6817 , A61B5/6847 , A61B17/24 , A61B17/3423 , A61B2017/3445 , A61B2017/3447 , A61B2017/345
Abstract: The disclosure provides systems and methods of use pertaining to precise measurements of middle ear mechanics to aid physicians in the determination of pre-operative, intraoperative, and post-repair stiffness of the ossicular chain to assist in the diagnosis and treatment and/or repair of all types of conductive hearing loss. One embodiment provides a handheld diagnostic tool having a load cell operably coupled between a linear actuator and a rigid probe configured to rest against the ossicular chain. When the actuator displaces the load cell and the rigid probe a predetermined distance in an oscillating manner, the load cell measures a force required to displace the ossicular chain a corresponding distance. Force and displacement data is sent to a processing element, which calculates a stiffness of the ossicular chain and reports information regarding the stiffness to a display. Other embodiments are also disclosed.
-
239.发明申请公开(公告)号：US20170183388A1
公开(公告)日：2017-06-29
申请号：US15300974
申请日：2015-04-02
Inventor： Michael H. B. STOWELL , Mikhail PLAM
IPC: C07K14/475 , G01N33/50 , G01N33/68
CPC classification number: C07K14/475 , A61K38/00 , C07K14/4703 , C07K14/4711 , G01N33/5008 , G01N33/6896 , G01N2500/02 , G01N2800/2821
Abstract: The invention provides compounds for the treatment of Alzheimer's disease, methods for the use of such compounds, assays for the identification of such compounds, and methods for diagnosis of Alzheimer's disease and diagnostic kits. Methods of marketing compounds are also disclosed. In one aspect, the disclosure provides a compound for the diagnosis or treatment of Alzheimer's disease wherein the compound is a modulator that inhibits the disruption by amyloid β of a complex comprising synaptophysin and/or synaptobrevin. In another aspect, the disclosure provides a pharmaceutical composition comprising the compounds disclosed herein in an amount sufficient to treat Alzheimer's disease in a subject. In another aspect, the disclosure provides a diagnostic composition comprising the compound disclosed herein.
-
公开(公告)号：US09681946B2
公开(公告)日：2017-06-20
申请号：US15054915
申请日：2016-02-26
Inventor： Malik Y. Kahook , Naresh Mandava , Glenn Sussman , Paul McLean , Robert E. Atkinson
CPC classification number: A61F2/1648 , A61F2/16 , A61F2/1613 , A61F2/1662 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F2002/1681 , A61F2002/1683 , A61F2002/1689 , A61F2002/169 , A61F2002/16902 , A61F2220/0025 , A61F2250/006
Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.
-
-
-
-
-
-
-
-
-
Search Results
1620
records
(took 0.057 seconds)
