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    Purification of proteins
    251.
    发明授权
    Purification of proteins 有权

    公开(公告)号：US09376464B2

    公开(公告)日：2016-06-28

    申请号：US13747495

    申请日：2013-01-23

    Applicant: EMD Millipore Corporation

    Inventor： Wilson Moya ,  Jad Jaber

    IPC: C07K1/30 ,  C07K1/32

    CPC classification number: C07K1/32 ,  C07K1/30

    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

    IHC, Tissue Slide Fluid Exchange Disposable And System
    258.
    发明申请
    IHC, Tissue Slide Fluid Exchange Disposable And System 审中-公开
    IHC，组织滑动液体交换一次性和系统

    公开(公告)号：US20150260621A1

    公开(公告)日：2015-09-17

    申请号：US14618007

    申请日：2015-02-10

    Applicant: EMD Millipore Corporation

    Inventor： Chris Scott ,  Paul Sydlowski ,  John Doyle ,  Ryan Amara ,  Libby Kellard ,  Sara Gutierrez ,  Marc Emerick

    IPC: G01N1/31

    Abstract: Apparatus and method for Immunohistochemistry, including a slide holder assembly fixture, a slide holder, a slide holder frame, and a slide holder frame assembly adapted to be placed in communication with a driving force to draw fluid through the slide holder. The slide holder may include an injection port that allows consistent fluid delivery and recovery, while minimizing the introduction of air bubbles. The slide holder may include a reservoir that allows for filling, soaking, rinsing, flushing, uniform antibody coverage of the tissue and reduces handling time, space, and errors, and one or more sample chambers. The slide orientation in the slide holder allows for visualization of label information and tissue to confirm adequate antibody coverage. A multi-port frame allows multiple assays to be carried out concurrently, and is removable from a vacuum manifold and allows for easy transport from the vacuum manifold to an incubator/refrigerator and back.

    Abstract translation: 用于免疫组织化学的装置和方法，包括滑动支架组件夹具，滑动支架，滑动支架框架和滑动支架框架组件，其适于与驱动力连通以将流体通过滑块保持器拉动。 滑动架可以包括一个注射口，其允许一致的流体输送和回收，同时最小化气泡的引入。 载玻片保持器可以包括允许填充，浸泡，漂洗，冲洗，组织的均匀抗体覆盖并减少处理时间，空间和错误以及一个或多个样品室的储存器。 幻灯片固定器中的滑动方向允许标记信息和组织的可视化，以确认足够的抗体覆盖。 多端口框架允许多个测定同时进行，并且可从真空歧管移除，并且允许从真空歧管到培养箱/冰箱和背部的容易运输。

    2D Low Level Mixing Bag For Storage And Shipping
    259.
    发明申请
    2D Low Level Mixing Bag For Storage And Shipping 有权
    2D低档混合袋储存和运输

    公开(公告)号：US20150258513A1

    公开(公告)日：2015-09-17

    申请号：US14440376

    申请日：2013-11-05

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： Martin Morrissey ,  Brian Pereira

    IPC: B01F15/00 ,  B01F13/08 ,  B01F7/00

    CPC classification number: B01F15/0085 ,  B01F7/00241 ,  B01F13/0827 ,  B01F15/00487 ,  B01F2215/0034 ,  B01F2215/0073 ,  C12M23/14 ,  C12M27/02

    Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.

    Abstract translation: 用于流体的一次性容器，例如可变形袋，具有一个或多个入口和一个或多个出口以及容器内的叶轮组件，用于引起包含或添加的一种或多种成分的混合，分散，均化和/或循环 到容器 容器内可容纳液体的区域是漏斗形的，其允许非常低的液面混合，分配同时混合，以及减少或消除涡流形成。

    Prefilter System for Biological Systems
    260.
    发明申请
    Prefilter System for Biological Systems 审中-公开
    生物系统预过滤系统

    公开(公告)号：US20150258468A1

    公开(公告)日：2015-09-17

    申请号：US14728496

    申请日：2015-06-02

    Applicant: EMD Millipore Corporation

    Inventor： Martin Siwak

    IPC: B01D15/12 ,  B01D15/38

    CPC classification number: B01D15/125 ,  B01D15/3804 ,  B01D15/3809 ,  B01D29/41 ,  B01D39/083 ,  B01D39/086 ,  B01D39/1607 ,  B01D39/18 ,  B01D39/20 ,  B01D61/142 ,  B01D61/16 ,  B01D69/141 ,  B01D2239/0407 ,  B01D2239/0428 ,  B01D2239/065 ,  B01D2239/0654 ,  B01D2239/0695 ,  B01D2311/04 ,  B01J20/28014 ,  B01J20/28028 ,  C12P21/00 ,  B01D2311/2649 ,  B01D2311/2626

    Abstract: The present invention is to a prefilter for affinity chromatography columns. The prefilter, positioned upstream of the column inlet, reduces the presence of non-specific binding (NSB) species that enter the system, thereby extending the yield, capacity and lifetime of the column. Suitable agents include but are not limited to hydrophobic entities; lipophilic entities; activated carbon; charged cation or anion entities; ligands; particles such as fumed silica, glass, controlled pore glass or derivitized version of each; silica or silicates; and combinations thereof. The material(s) can be incorporated into a variety of media such as fibers, beads, membranes and the like and then incorporated into a variety of device designs including lenticular pads, depth filters, bead containing columns, spiral wound devices, TFF devices and the like.

    Abstract translation: 本发明涉及亲和层析柱的预过滤器。 位于柱入口上游的预过滤器减少进入系统的非特异性结合（NSB）物质的存在，从而延长柱的产率，容量和寿命。 合适的试剂包括但不限于疏水性实体; 亲脂性实体; 活性炭; 带电阳离子或阴离子实体; 配体; 颗粒如煅制二氧化硅，玻璃，受控孔玻璃或每种的衍生版本; 二氧化硅或硅酸盐; 及其组合。 这些材料可以结合到各种介质如纤维，珠粒，膜等中，然后结合到各种装置设计中，包括透镜衬垫，深度过滤器，包含珠的柱，螺旋缠绕装置，TFF装置和 类似。

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