公开(公告)号：US20170319704A1

公开(公告)日：2017-11-09

申请号：US15145020

申请日：2016-05-03

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Willy Chin ,  Yukti Choudhury ,  Shujun Gao ,  James L. Hedrick ,  Xiyu Ke ,  Min-Han Tan ,  Jye Yng Teo ,  Yi Yan Yang

IPC: A61K47/60 ,  C08G63/42 ,  A61K9/00 ,  A61K47/58 ,  C08G64/18 ,  C08G64/02 ,  C08G63/78 ,  A61K31/704

CPC classification number: A61K47/60 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/704 ,  A61K47/58 ,  C08G63/42 ,  C08G63/78 ,  C08G64/02 ,  C08G64/025 ,  C08G64/183

Abstract: Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide groups and carboxylic acid groups. The BCPs form self-assembled micellar particles in aqueous solution that can be loaded with hydrophobic drugs for therapeutic drug delivery. The loaded particles have small particle sizes (

公开(公告)号：US20170319690A1

公开(公告)日：2017-11-09

申请号：US15623679

申请日：2017-06-15

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-i Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo

IPC: A61K39/395 ,  G01N33/574 ,  A61K45/06 ,  G01N33/53 ,  C07K14/705 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/53 ,  G01N33/57484 ,  G01N2800/52 ,  Y02A50/41 ,  Y02A50/412

Abstract: Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

公开(公告)号：US20170314024A1

公开(公告)日：2017-11-02

申请号：US15526716

申请日：2015-11-16

Applicant: VIB VZW ,  Katholieke Universiteit Leuven, K.U.Leuven R&D ,  Agency for Science, Technology and Research (A*Star)

Inventor： Jean-Christophe Marine ,  Ernesto Guccione ,  Marco Bezzi

IPC: C12N15/113 ,  A61K31/713 ,  C12Q1/68 ,  A61K45/06

Abstract: The present application relates to the field of cancer, particularly that of cancers with high MDM4 protein levels (such as melanoma, breast, colon or lung cancers, glioblastoma, retinoblastoma, etc.). It is shown herein that direct and selective inhibition of MDM4, e.g., by antisense RNA, leads to growth inhibition of cancer cells and sensitization to chemo or targeted therapies. Also provided are simple ways of determining which patients are most amenable for such treatment by comparing specific transcript levels.

公开(公告)号：US09802902B2

公开(公告)日：2017-10-31

申请号：US15297906

申请日：2016-10-19

Applicant: Agency for Science, Technology and Research

Inventor： Yugen Zhang ,  Jackie Y. Ying ,  Lihong Liu ,  Hong Wu

IPC: C07D233/61 ,  A61K31/787 ,  A01N43/50

CPC classification number: C07D233/61 ,  A01N43/50 ,  A61K31/787

Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.

公开(公告)号：US20170308523A1

公开(公告)日：2017-10-26

申请号：US15523201

申请日：2015-11-24

Applicant: Agency for Science, Technology and Research

Inventor： Zhaoxia Wang ,  Siow Mong Rick Goh ,  Yinping Yang

IPC: G06F17/27

CPC classification number: G06F17/279 ,  G06F17/2705 ,  G06F17/273 ,  G06F17/2735 ,  G06F17/274 ,  G06F17/2775 ,  G06Q10/10 ,  G06Q30/0201 ,  G06Q50/01

Abstract: A system and a method for classifying text messages, such as social media messages into sentiment valence categories are provided. The system comprising a module for decomposing text messages, a module for cleaning text messages, a module for producing feature data of text messages, and a module for classifying text messages into sentiment valence categories. The module for decomposing text messages is configured to: receive a text message, parse the text message into separate portions in response to parsing criteria based on sentence delimiters, wherein the separate portions are sentences, phrases and words, and rejoin at least some of the separate portions of the text message into sentences in response to predefined linguistic conditions.

公开(公告)号：US20170304369A1

公开(公告)日：2017-10-26

申请号：US15517912

申请日：2015-10-08

Applicant: Agency for Science, Technology and Research

Inventor： Lay Teng ANG ,  Kyle M. LOH ,  Bing LIM

IPC: A61K35/407 ,  C12N5/071 ,  C12N5/073 ,  G01N33/00 ,  C12N5/00

CPC classification number: A61K35/407 ,  C12N5/00 ,  C12N5/0603 ,  C12N5/067 ,  C12N5/0672 ,  C12N2500/38 ,  C12N2500/44 ,  C12N2501/00 ,  C12N2501/01 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/237 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/415 ,  C12N2501/42 ,  C12N2501/727 ,  C12N2506/02 ,  G01N33/00

Abstract: The present disclosure provides methods and kits for the differentiation of stem cells into relevant liver cell lineages, as well as methods of using the relevant liver cell lineages in screening for a cellular response, a phenotype and in the treatment of a condition. In one embodiment, stem cells are first differentiated into cells of the definitive endoderm lineage, which are differentiated into posterior foregut (PFG) lineage cells by one or more of retinoic acid activators and/or one or more inhibitors of transforming growth factor-β (TGFβ). An additional embodiment provides a method for the differentiation of posterior foregut lineage cells into liver bud progenitors (LB) by one or more activators of TGFβ signalling, and/or one or more modulators of Wnt signalling, and/or one or more activators of cyclic AMP/PKA signaling; and a further embodiment provides a method for the differentiation of liver bud progenitors into hepatic progenitors by one or more inhibitors of TGFβ signalling and/or fibroblast growth factor (FGF) inhibitors and/or one or more Notch inhibitors. Another embodiment discloses the differentiation of hepatic progenitors into hepatocyte-like cells or perivenous hepatocyte-like cells by one or more of Notch inhibitors and/or activators of glucocorticoid signalling and/or one or more activators of insulin signalling and/or one or more of ascorbic acid signalling activators and/or additional factors. Methods and kits for maintaining LB in self renewal state, hepatocyte-like cells in perivenous or periportal state, as well as surface markers for LB and mid/hindgut (MHG) cells are also disclosed.

公开(公告)号：US09799831B2

公开(公告)日：2017-10-24

申请号：US14655716

申请日：2013-12-27

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jun Li ,  Kok Haw Ong ,  Zhikuan Chen ,  Yujun Zhao ,  Siew Lay Lim ,  Ivy Wong ,  Lee Yang ,  Kang Yee Seah

IPC: H01L51/00 ,  C09D5/24 ,  C08G75/32 ,  H01L51/42 ,  C08G75/00 ,  C08G61/12 ,  C08K3/04

CPC classification number: H01L51/0036 ,  C08G61/123 ,  C08G61/126 ,  C08G75/32 ,  C08G2261/124 ,  C08G2261/1412 ,  C08G2261/143 ,  C08G2261/3142 ,  C08G2261/3223 ,  C08G2261/3246 ,  C08G2261/364 ,  C08G2261/414 ,  C08G2261/91 ,  C08K3/04 ,  C08K3/045 ,  C08L65/00 ,  C09D5/24 ,  H01L51/0002 ,  H01L51/0007 ,  H01L51/0037 ,  H01L51/0043 ,  H01L51/4253 ,  H01L2251/308 ,  Y02E10/549

Abstract: There is provided p-type organic polymers of general formula I. The polymers may be useful as semi-conducting material. Thus, thin films and devices comprising such polymers are also provided.

公开(公告)号：US20170281662A1

公开(公告)日：2017-10-05

申请号：US15627607

申请日：2017-06-20

Applicant: International Business Machines Corporation ,  Agency For Science, Technology and Research ,  Universidad del PaÌs Vasco/Euskal Herriko Unibertsitatea

Inventor： Julian M. W. Chan ,  Amanda C. Engler ,  James L. Hedrick ,  Haritz Sardon ,  Jeremy P. K. Tan ,  Yi Yan Yang

IPC: A61K31/704 ,  A61K31/713 ,  A61K9/51

CPC classification number: A61K47/34 ,  A61K9/5146 ,  A61K31/704 ,  A61K31/713 ,  A61K38/00 ,  A61K38/16 ,  C08G64/0241 ,  C08G64/183 ,  C08L69/00

Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

公开(公告)号：US20170277447A1

公开(公告)日：2017-09-28

申请号：US15508866

申请日：2015-09-28

Applicant: Agency For Science, Technology And Research

Inventor： Weiya XI ,  Chao JIN ,  Khai Leong YONG ,  Pantelis ALEXOPOULOS

IPC: G06F3/06 ,  G06F12/0811

CPC classification number: G06F3/0613 ,  G06F3/06 ,  G06F3/061 ,  G06F3/0611 ,  G06F3/0658 ,  G06F3/0659 ,  G06F3/067 ,  G06F3/0671 ,  G06F3/0683 ,  G06F3/0685 ,  G06F12/0238 ,  G06F12/0811 ,  G06F2212/62

Abstract: A printed circuit board assembly (PCBA) for a storage device comprising a non-volatile memory (NVM) and a multi-core processor, wherein a first core of the multi-core processor is devoted to external interface management and a second core of the multi-core processor is devoted to internal data management.

公开(公告)号：US20170270044A1

公开(公告)日：2017-09-21

申请号：US15506565

申请日：2015-10-02

Applicant: Agency for Science, Technology and Research

Inventor： Hong YANG ,  Khai Leong YONG ,  Dee Meng KANG

IPC: G06F12/0804 ,  G06F3/06

CPC classification number: G06F12/0804 ,  G06F3/0605 ,  G06F3/0607 ,  G06F3/0613 ,  G06F3/0617 ,  G06F3/0629 ,  G06F3/0647 ,  G06F3/0685 ,  G06F3/0689 ,  G06F2212/1032

Abstract: An active storage unit and an active storage array are provided. The active storage unit includes an active control board having a processor, at least one internal memory module communicatively coupled to the processor, and a reconfigurable logic circuit communicatively coupled to the processor for programming the active storage unit. The active storage unit also includes a plurality of storage devices communicatively coupled to the active control board.