Abstract:
The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
Abstract:
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, in which E is X is N or CH, W is —NR16R17, —NR16C(═O)R22, —NR16CO2R22, —OR23, or a heteroaryl or heterocyclo group as defined in the specification, and R1 through R12, R16, R17, R22, R23, x, y, and z are as defined in the specification, are useful as modulaters of melanocortin receptors, particularly MC-1R and MC-4R.
Abstract translation:具有式(I)的化合物及其药学上可接受的盐,水合物和前药,其中E是X是N或CH,W是-NR 16 R 17, ,-NR 16 C(-O)R 22,-NR 16 CO 2 R 22 或者如说明书中定义的杂芳基或杂环基,R 1至R 12,R 12, R 17,R 17,R 22,R 23,x,y和z定义如上 说明书可用作黑皮质素受体的调节剂,特别是MC-1R和MC-4R。
Abstract:
The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
Abstract:
An RF device comprising a plurality of drift tubes, each drift tube having a plurality of gaps defining resonant cavities, is immersed in an axial magnetic field. RF energy is introduced at an input RF port at one of these resonant cavities and collected at an output RF port at a different RF cavity. A plurality of electron beams passes through these drift tubes, and each electron beam has an individual magnetic shaping applied which enables confined beam transport through the drift tubes.
Abstract:
A data switching system is described to allow arbitrary types of connections to be established over arbitrary link types that include link types that do not inherently support virtual circuits. The data switching system includes a label switching system to establish virtual circuit connections over any link types. The data switching system also includes a connection routing and signaling controller, coupled to the label switching system to determine routes for connection over any link types.
Abstract:
A grating comprising a plurality of substantially parallel members having a conducting surface of depth L, separated by a dielectric layer gap, and having of pitch &lgr;g and where L>16&lgr;g. The members are preferably metallic or comprise metallic foil covered plastic. The gap may be filled wholly or partially with dielectric material including liquid crystal whose refractive index can be controlled by suitable application of voltage across the gap.
Abstract:
Disclosed is a system, method, and program for magnifying displayed content downloaded from a server over a network. Information is received indicating selection of a region of the displayed content to magnify. A determination is made of at least one region of the selected region including image content. The server maintains a high resolution file version and a low resolution file version of the image content. A determination is then made as to whether the selected image content from the displayed image file is the low resolution file version. If so, a command is generated to retrieve from the server specific byte locations from the high resolution file version including the image content in the selected region. The specified bytes are less than all the image data bytes in the high resolution version of the file if the image content in the selected region comprises less than all of the image content maintained in the high resolution version of the file.
Abstract:
A connection control interface for switches in a network is provided. The connection control interface allows the multiservice switch to provide a number of switch resource partitions to a number of independent controllers coupled to the switch. The switch resource partitions comprise a number of subsets of switch resources that define a number of independent subset networks of a physical network. The connection control interface allows the independent controllers to control the connections of the switch using the number of switch resource partitions. The independent controllers each use one of a number of control systems, the control systems comprising a network software level. The independent controllers comprise a virtual switch interface having a master component and a slave component where the master and slave components may be hosted on different processors. The slave components may be hosted on a control card that controls a number of port cards of the switch or on a port card processor. The switch and the independent controllers are resynchronized when discrepancies are detected between the connections on the switch and those expected by the each of the plurality of independent controllers.
Abstract:
A digital programmable delay which provides a series of pulses that are programmed in both pulse latency and trigger latency to control the operation of a memory module test system.