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公开(公告)号：US10111787B2
公开(公告)日：2018-10-30
申请号：US14424379
申请日：2013-08-26
Applicant: Agency for Science, Technology and Research
Inventor： Jackie Y. Ying , Guolin Xu , Rensheng Deng , Xiaojun Chen
Abstract: Various embodiments provide an apparatus for a diaper. The apparatus has two electrodes and an electronic device. The electronic device is coupled to the two electrodes. The two electrodes are operable to generate a potential difference when they are electrically connected together by ionized liquid. The electronic device is operable to generate an alarm signal when the potential difference is generated. Various other embodiments relate to a corresponding system, diaper and method of manufacturing an electrode.
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公开(公告)号：US09802902B2
公开(公告)日：2017-10-31
申请号：US15297906
申请日：2016-10-19
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Jackie Y. Ying , Lihong Liu , Hong Wu
IPC: C07D233/61 , A61K31/787 , A01N43/50
CPC classification number: C07D233/61 , A01N43/50 , A61K31/787
Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
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公开(公告)号：US09663874B2
公开(公告)日：2017-05-30
申请号：US14385562
申请日：2013-03-18
Applicant: Agency for Science, Technology and Research
Inventor： Andrew Chwee Aun Wan , Meng Fatt Leong , Tze Chiun Lim , Jackie Y. Ying , Jerry Kah Chin Toh
CPC classification number: D01D5/12 , A61L27/24 , A61L27/38 , A61L27/56 , C12N11/04 , C12N2500/34 , C12N2500/50 , D01D5/30 , D01D5/38
Abstract: There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber.
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公开(公告)号：US20160243550A1
公开(公告)日：2016-08-25
申请号：US15025858
申请日：2013-09-30
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jackie Y. Ying , Saravana Kumar Kumarasamy , Rensheng Deng
CPC classification number: B01L3/502746 , B01L3/502738 , B01L2200/0642 , B01L2200/0647 , B01L2300/0636 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2300/0893 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0677 , B01L2400/0688 , B01L2400/084 , C12Q1/686 , C12Q1/689 , C12Q2600/16 , C12Q2531/107 , C12Q2565/629
Abstract: There is provided a microfluidic device comprising: a plurality of wells, each well having an inlet and an outlet, wherein the inlets are in fluid communication with one or more entry channels and the outlets are in fluid communication with one or more exit channels, wherein said outlet is connected to the exit channel via an outlet connecting channel and said inlet is connected to the entry channel via an inlet connecting channel wherein the dimension of the outlet connecting channel is configured such that the surface tension of a liquid comprised in the well prevents the release of the liquid through the outlet connecting channel. There is also provided a system, method and use of the device.
Abstract translation: 提供了一种微流体装置，其包括：多个井，每个井具有入口和出口，其中入口与一个或多个入口通道流体连通，并且出口与一个或多个出口通道流体连通，其中 所述出口通过出口连接通道连接到出口通道，并且所述入口通过入口连接通道连接到入口通道，其中出口连接通道的尺寸被构造成使得包含在井中的液体的表面张力防止 通过出口连接通道释放液体。 还提供了该设备的系统，方法和用途。
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25.发明申请METHOD FOR TREATING FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS 审中-公开用咪唑和咪唑啉化合物治疗纤维化和癌症的方法公开(公告)号：US20160000757A1
公开(公告)日：2016-01-07
申请号：US14789928
申请日：2015-07-01
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Lang Zhuo , Chunyan Zhang , Yugen Zhang , Jackie Y. Ying , Began Gopalan , Zhiyuan Ke , Zhaobing Ding
IPC: A61K31/4178
CPC classification number: A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/439 , A61K31/4439 , C07D233/58 , C07D233/60 , C07D233/61 , C07D235/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04 , C07D487/22
Abstract: There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium compounds as described herein, including imidazolium and imidazolinium salts.
Abstract translation: 目前提供了将抗纤维化或抗癌剂递送至细胞的方法。 所述方法包括使细胞与本文所述的有效量的咪唑鎓和咪唑啉化合物接触，包括咪唑鎓和咪唑啉鎓盐。
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Patent Agency Ranking
公开(公告)号：US20150203454A1
公开(公告)日：2015-07-23
申请号：US14420859
申请日：2013-08-07
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Jackie Y. Ying , Lihong Liu , Hong Wu
IPC: C07D233/61 , A01N43/50
CPC classification number: C07D233/61 , A01N43/50 , A61K31/787
Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
Abstract translation: 提供用于治疗的化合物，所述化合物包含亲水性杂环胺单体的重复单元，所述亲水性杂环胺单体通过被选择赋予治疗效果的疏水性接头偶联。 还提供了上述化合物在制备用于治疗真菌感染的药物中的用途以及使用上述化合物治疗真菌感染的方法。
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27.发明申请METHOD FOR DIFFERENTIATING EMBRYONIC STEM CELLS INTO CELLS EXPRESSING AQP-1 审中-公开将胚胎干细胞分化成表达AQP-1的细胞的方法公开(公告)号：US20130268060A1
公开(公告)日：2013-10-10
申请号：US13917269
申请日：2013-06-13
Applicant: Agency for Science, Technology and Research
Inventor： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
CPC classification number: C12N5/0686 , A61F2/06 , C12N2501/11 , C12N2501/155 , C12N2506/02
Abstract: The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
Abstract translation: 本发明涉及将人胚胎干（ES）细胞分化成表达AQP-1的细胞，特别是肾上皮细胞的方法。 所公开的方法包括在细胞外基质分子的存在下在肾特异性培养基中培养人ES细胞。 根据所述方法产生的细胞可用于治疗肾脏相关疾病如肾衰竭，肾病，光明病和肾小球炎。
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公开(公告)号：US11387451B2
公开(公告)日：2022-07-12
申请号：US16343736
申请日：2017-10-20
Applicant: Agency for Science, Technology and Research
Inventor： Jackie Y. Ying , Ayman Amin Abdelhamid
IPC: H01M4/13 , H01M4/48 , C01G19/02 , C01G23/08 , C01G25/02 , C01G33/00 , C01G45/02 , C01G49/02 , C01G51/04 , C01G51/00 , C01G53/04 , C01G53/00 , H01M4/485 , H01M4/52 , H01M4/525 , H01M10/0525 , H01M4/50 , B82Y30/00 , B82Y40/00 , H01M4/02
Abstract: The present invention generally relates to a method for preparing metal oxide nanosheets. In a preferred embodiment, graphene oxide (GO) or graphite oxide is employed as a template or structure directing agent for the formation of the metal oxide nanosheets, wherein the template is mixed with metal oxide precursor to form a metal oxide precursor-bonded template. Subsequently, the metal oxide precursor-bonded template is calcined to form the metal oxide nanosheets. The present invention also relates to a lithium-ion battery anode comprising the metal oxide nanosheets. In a further preferred embodiment, the battery anode may comprising reduced template, which is reduced graphene oxide (rGO) or reduced graphite oxide.
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29.发明申请公开(公告)号：US20220001385A1
公开(公告)日：2022-01-06
申请号：US17360014
申请日：2021-06-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jackie Y. Ying , Min-Han Tan , Yoke San Daniel Lee , Igor Cima , Yeon Joon Park , Wai Min Phyo
IPC: B01L3/00 , C12N5/071 , G01N33/50 , G01N33/574 , C12Q1/6886
Abstract: A device and method for retrieving cells of interest, in particular rare cells, were disclosed. Tumor-derived endothelial cell clusters (TECCs) retrieved using the disclosed device and method can be used for the diagnosis and prognosis of cancer.
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公开(公告)号：US10718012B2
公开(公告)日：2020-07-21
申请号：US15029616
申请日：2014-10-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jackie Y. Ying , Saravana Kumar Kumarasamy
IPC: G01J5/60 , C12Q1/686 , C12Q1/6825
Abstract: A multiplexed polymerase chain reaction (PCR) DNA detection system and a method for DNA detection within the PCR system are provided. The PCR DNA detection system includes a color charge-coupled device (CCD) camera, fluorophore-quencher probes and an imaging chamber. The fluorophore-quencher probes are selected in response to fluorophores quenched by the fluorophore-quencher probes corresponding to three selected primary colors and peak channel responses of the CCD camera such that emission profiles of the fluorophores substantially match the three selected primary colors and peak emission profiles of the fluorophores correspond to the peak RGB channel responses of the CCD camera. A DNA sample and the fluorophore-quencher probes are located within the imaging chamber. The color CCD camera is focused on the imaging chamber for simultaneous detection of up to three targets from fluorescence of the DNA sample and the fluorophore-quencher probes.
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