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Patent Agency Ranking
公开(公告)号：US10293083B2
公开(公告)日：2019-05-21
申请号：US15398254
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A01N25/00 , A01N47/00 , C12N5/00 , C12N5/02 , A61L27/38 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/50 , A61L27/52 , A61L26/00 , A61K9/06 , A61K35/33 , C12N5/071
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US09988423B2
公开(公告)日：2018-06-05
申请号：US14380615
申请日：2013-02-22
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Archana Mishra
IPC: A61K38/00 , A61P17/00 , A61K38/08 , A61K38/06 , A61K38/07 , C08L89/00 , C08L91/00 , C09D189/00 , C09D191/00 , C09J189/00 , C09J191/00 , H01B1/00 , H01B1/12 , A23L1/05 , A23L1/06 , C07K7/06 , A61K8/64 , C07K5/083 , C07K5/062 , A61K9/06 , A61K47/34 , A61K8/04 , A61Q19/00 , A61K9/107 , A61K45/06 , H01L51/00
CPC classification number: C07K7/06 , A61K8/042 , A61K8/64 , A61K9/06 , A61K9/107 , A61K38/06 , A61K38/08 , A61K45/06 , A61K47/34 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C07K5/06034 , C07K5/0808 , H01L51/0093
Abstract: The present invention relates to organogels and emulsions based on ultrasmall self-assembling peptides. It further relates to methods for producing such organogels and emulsions as well as to the use of the organogels and emulsions in biological and non-biological applications.
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公开(公告)号：US20170196993A1
公开(公告)日：2017-07-13
申请号：US15324144
申请日：2015-07-08
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Ming Ni
CPC classification number: A61K49/00 , A61K9/14 , A61K47/42 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/52 , C07K5/06034 , C07K5/0808 , C07K5/101 , C07K14/78 , C12Q1/02
Abstract: Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings.
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公开(公告)号：US20170182218A1
公开(公告)日：2017-06-29
申请号：US15398288
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20130267455A1
公开(公告)日：2013-10-10
申请号：US13751295
申请日：2013-01-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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