公开(公告)号：US20120277696A1

公开(公告)日：2012-11-01

申请号：US13456570

申请日：2012-04-26

申请人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

IPC分类号： A61M1/00

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

摘要翻译： 本发明一般涉及通过装置开口接收体液。 在一个方面，该装置包括流动活化器，其布置成使流体从受试者释放。 部署致动器可以在展开方向上致动流动活化器，这又可导致流体从受试者释放。 流动活化剂也可以通过回缩致动器在回缩方向上移动。 在一个方面，设备可以包括真空源，其可以帮助促进流体流入设备的开口中和/或可以帮助促进流体从开口流到储存室。 在一个方面，设备致动器可以实现开口和真空源之间的流体连通，并且在启用流体连通之后可以启动流动活化器。

公开(公告)号：US20120275955A1

公开(公告)日：2012-11-01

申请号：US13456505

申请日：2012-04-26

申请人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Howard Bernstein ,  Kristin Horton

发明人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Howard Bernstein ,  Kristin Horton

IPC分类号： B01D71/68 ,  B01D71/10 ,  A61M1/34 ,  B01D63/00

CPC分类号： A61B5/150099 ,  A61B5/1411 ,  A61B5/1438 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150419 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15105 ,  A61B5/15142 ,  A61B5/154 ,  A61B10/0045 ,  A61B2562/0295 ,  A61M1/34 ,  A61M1/3486 ,  A61M1/3687 ,  A61M2202/0415 ,  A61M2205/3334 ,  B01L3/502753 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0688 ,  G01N33/18 ,  G01N33/1826

摘要： In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.

摘要翻译： 在一些实施方案中，本发明一般涉及在装置内分离血液以形成血浆或血清。 在一些实施方案中，本发明一般涉及去除包含在装置内的流体，例如血液。 例如，可以将装置施加到受试者的皮肤以从受试者接收血液，并将血液通过分离膜，该分离膜将血液分离成血浆，并将部分浓缩在血细胞中。 作为另一个例子，血液或血浆可能被允许在装置内凝结，血清（未经切开的血液部分）可以从装置中取出。 在一些情况下，该装置可以包含诸如预包装真空的真空源，以便于接收血液和/或使血液通过分离膜以产生血浆​​或血清。

公开(公告)号：US20120041338A1

公开(公告)日：2012-02-16

申请号：US13208770

申请日：2011-08-12

申请人： Donald E. Chickering, III ,  Douglas A. Levinson ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  David R. Walt

发明人： Donald E. Chickering, III ,  Douglas A. Levinson ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  David R. Walt

IPC分类号： A61B5/15 ,  A61M5/00

CPC分类号： A61M37/0015 ,  A61B5/117 ,  A61B5/14514 ,  A61B5/150984 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B90/96 ,  A61B90/98 ,  A61B2560/0412 ,  A61M5/14248 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/3576 ,  A61M2205/6009 ,  A61M2205/6072 ,  A61N1/30 ,  A61N1/325

摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.

摘要翻译： 本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。 在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。 在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。 在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。

公开(公告)号：US20110125058A1

公开(公告)日：2011-05-26

申请号：US12953744

申请日：2010-11-24

申请人： Douglas A. Levinson ,  Howard Bernstein ,  Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie

发明人： Douglas A. Levinson ,  Howard Bernstein ,  Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie

IPC分类号： A61B5/15 ,  G09B19/00

CPC分类号： A61B5/150984 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/74 ,  A61B10/0045 ,  A61B2010/008

摘要： The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device.

摘要翻译： 本发明总体上涉及用于从主体取样流体的系统和方法。 流体可以是任何合适的体液，例如血液或间质液。 在某些情况下，受试者是患者。 受试者可以具有可以应用于受试者的皮肤（例如受试者或其他人）的装置，并且该装置能够获得流体样本。 流体可以存储在装置中的储存器中，并且可以在任何方便的时间（例如在家中，远离保健设置等）从受试者获得流体。在一些实施例中，装置或其一部分 ，可以返回到临床和/或实验室设置以分析存储在装置内的流体。

公开(公告)号：US20110105872A1

公开(公告)日：2011-05-05

申请号：US12915735

申请日：2010-10-29

申请人： Donald E. Chickering, III ,  Douglas A. Levinson ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  David R. Walt

发明人： Donald E. Chickering, III ,  Douglas A. Levinson ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  David R. Walt

IPC分类号： A61B5/157 ,  A61B5/15

CPC分类号： A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150106 ,  A61B5/150122 ,  A61B5/150129 ,  A61B5/150137 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150893 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.

摘要翻译： 本发明在某些方面一般涉及用于皮肤的系统和方法，以及对其致动，传递和/或感知的控制。 例如，本发明的某些方面通常涉及用于递送到和/或从流体或从受试者递送到皮肤和/或从皮肤下方的装置。 在一个方面，流体的递送和/或排出至少部分地模糊。 例如，遮蔽可以是时间，和/或通过感觉遮蔽（例如，通过提供触觉，嗅觉，听觉和/或视觉感觉）。 本发明的某些方面通常涉及能够在活化后自动递送至皮肤和/或皮下的流体的装置，例如在流体被输送和/或取出而不需要任何额外干预的情况下 。 可以通过任何合适的技术来激活装置。 在其他方面，装置可以包含在包装中，并且当从包装中取出时，可以构造和布置该装置，以便当该装置应用于皮肤时能够输送和/或抽出流体，并且在某些情况下 ，自动地和/或没有受试者或另一个人的进一步干预。

公开(公告)号：US20110066134A1

公开(公告)日：2011-03-17

申请号：US12755989

申请日：2010-04-07

申请人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

发明人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

IPC分类号： A61N1/30

CPC分类号： A61K31/137 ,  A61K9/0009 ,  A61K9/0014

摘要： Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue.

摘要翻译： 描述了适用于其离子电渗疗法的药物和制剂，其提供了抗真菌药物至少一个身体表面（例如钉子）的离子电渗疗法递送。 还描述了适用于包含特比萘芬的离子电渗疗法的药物制剂以及通过离子电渗疗法将特比萘芬给予体表面的方法。 当使用掩模将药物源引入指甲时，离子电渗治疗后指甲周边区域的特比萘芬浓度低于掩模下方的药物浓度。 此外，通过产生药物递送梯度来实现递送的药物浓度的差异。 药物可以根据不同组织表现出的不同转移效率递送到不同的组织，导致一个组织中相对于另一个组织的较高百分比递送。

公开(公告)号：US20130138058A9

公开(公告)日：2013-05-30

申请号：US13456570

申请日：2012-04-26

申请人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

IPC分类号： A61M1/00

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

公开(公告)号：US20100256465A1

公开(公告)日：2010-10-07

申请号：US12716229

申请日：2010-03-02

申请人： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie ,  Robert S. Langer ,  Timothy M. Blicharz

发明人： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie ,  Robert S. Langer ,  Timothy M. Blicharz

IPC分类号： A61B5/00 ,  A61B5/145 ,  G01N21/00

CPC分类号： A61B5/150099 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0077 ,  A61B5/1438 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15125 ,  A61B5/157 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/4845 ,  A61B5/486 ,  A61B5/685 ,  A61B5/6898 ,  A61B5/743

摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

摘要翻译： 本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。 在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差 访问站点的一部分。 在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与 介质由传感器确定。

公开(公告)号：US07468065B2

公开(公告)日：2008-12-23

申请号：US11021947

申请日：2004-12-23

申请人： David A. Weber ,  Ingrid Kane ,  Mike Rehal ,  Robert L. Lathrop, III ,  Kenny Aptekarev ,  Jeffrey Etter ,  Scott Gerondale ,  Rahul Bhagat ,  Shawn Davis

发明人： David A. Weber ,  Ingrid Kane ,  Mike Rehal ,  Robert L. Lathrop, III ,  Kenny Aptekarev ,  Jeffrey Etter ,  Scott Gerondale ,  Rahul Bhagat ,  Shawn Davis

IPC分类号： A61F9/00

CPC分类号： A61F2/167 ,  A61F9/0017 ,  A61F9/007

摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

摘要翻译： 用于输送眼部植入物或微量植入物的装置和方法。 该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。 提供小尺寸插管用于自密封输送方法。

公开(公告)号：US20060261055A1

公开(公告)日：2006-11-23

申请号：US11257354

申请日：2005-10-24

申请人： Andrew Child ,  Karen Green ,  Alfred Deangelis ,  David Wilson ,  Shawn Davis

发明人： Andrew Child ,  Karen Green ,  Alfred Deangelis ,  David Wilson ,  Shawn Davis

IPC分类号： H05B3/00

CPC分类号： H05B3/342 ,  H05B2203/003 ,  H05B2203/004 ,  H05B2203/005 ,  H05B2203/014

摘要： A warming mattress and mattress pad incorporating an insert layer or sheet with a scrim having one or more pairs of heating and/or sensor wires arranged in a continuous pattern such that pair members are disposed in crossing relation to one another. The pair members may be cut and joined to establish electrical connections at defined crossing points to establish feedback loop circuits with a control element.

摘要翻译： 一种加热床垫和床垫，其包括具有布置成具有连续图案布置的一对或多对加热和/或传感器线的稀松布的插入层或片材，使得对构件彼此交叉设置。 成对构件可以被切割和连接，以在限定的交叉点处建立电连接，以建立具有控制元件的反馈回路电路。