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    Nucleic acid quantification products and processes
    22.
    发明授权
    Nucleic acid quantification products and processes 有权

    公开(公告)号：US10533215B2

    公开(公告)日：2020-01-14

    申请号：US13129797

    申请日：2009-11-20

    Applicant: Charles R. Cantor

    Inventor： Charles R. Cantor

    IPC: C12Q1/68 ,  C12Q1/6837

    Abstract: Described herein are products and processes for nucleic acid quantification, which are in part useful for detecting and determining the nucleotide sequence of rare nucleic acids (i.e., low copy number nucleic acids) in a sample. Such products and processes are useful for reducing the dynamic range among different nucleic acid species.

    Methods and compositions for the analysis of nucleic acids
    23.
    发明授权
    Methods and compositions for the analysis of nucleic acids 有权
    用于分析核酸的方法和组合物

    公开(公告)号：US08852864B2

    公开(公告)日：2014-10-07

    申请号：US12863169

    申请日：2009-01-16

    Applicant: Charles R. Cantor

    Inventor： Charles R. Cantor

    IPC: C12Q1/68

    CPC classification number: C12Q1/6818 ,  C12Q1/6816 ,  C12Q1/6869 ,  C12Q2521/501 ,  C12Q2525/161 ,  C12Q2563/185

    Abstract: Provided herein are compositions and methods for analysis of nucleic acids, including, methods and compositions for genotyping, haplotyping, sequencing and performing other genetic and epigenetic analysis on nucleic acids, for example. In some embodiments, methods and compositions suitable for whole-genome sequencing on single molecules of nucleic acid are provided. In some embodiments, analysis of single molecules of nucleic acid are performed in conjunction with nanopores and/or nanopore devices.

    Abstract translation: 本文提供了用于核酸分析的组合物和方法，包括用于基因分型，单倍型，测序和对核酸进行其他遗传和表观遗传学分析的方法和组合物。 在一些实施方案中，提供适用于单分子核酸上的全基因组测序的方法和组合物。 在一些实施方案中，结合纳米孔和/或纳米孔装置进行单分子核酸的分析。

    Solid phase sequencing of biopolymers
    25.
    发明授权
    Solid phase sequencing of biopolymers 失效
    生物聚合物的固相测序

    公开(公告)号：US08758995B2

    公开(公告)日：2014-06-24

    申请号：US12852336

    申请日：2010-08-06

    Applicant: Charles R. Cantor ,  Hubert Koster

    Inventor： Charles R. Cantor ,  Hubert Koster

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C12Q1/6872 ,  C12Q1/6874 ,  C12Q2565/501 ,  C12Q2531/113 ,  C12Q2521/525 ,  C12Q2565/627 ,  C12Q2531/119 ,  C12Q2523/301 ,  C12Q2531/137 ,  C12Q2521/301 ,  C12Q2531/149

    Abstract: This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

    Abstract translation: 本发明涉及用于检测和测序靶核酸序列，批量修饰的核酸探针和可用于这些方法的探针阵列的方法，以及含有这些探针的试剂盒和系统。 有用的方法包括将代表靶的互补或同源序列的核酸或核酸与核酸探针阵列进行杂交。 这些探针包括在单链部分内的单链部分，任选的双链部分和可变序列。 该组的杂交核酸的分子量可以通过质谱法测定，并且靶标的序列由片段的分子量确定。 探针可以固定在诸如杂交芯片的固体支持物上，以便于自动化分子量分析和目标序列的鉴定。

    Nucleic acid supported protein complementation
    26.
    发明授权
    Nucleic acid supported protein complementation 有权
    核酸支持的蛋白质互补

    公开(公告)号：US07999095B2

    公开(公告)日：2011-08-16

    申请号：US12638871

    申请日：2009-12-15

    Applicant: Charles R. Cantor ,  Natalia E. Broude ,  Carlos Witte-Hoffman

    Inventor： Charles R. Cantor ,  Natalia E. Broude ,  Carlos Witte-Hoffman

    IPC: C07H21/04 ,  C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6818 ,  C12Q1/6813 ,  C12Q2563/131 ,  C12Q2561/107

    Abstract: The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When the two inactive polypeptide fragment are brought in close proximity during hybridization to a target nucleic acid, they re-associate into an active, detectable protein.

    Abstract translation: 本发明涉及用于靶核酸分子（包括DNA和RNA靶标）以及核酸类似物的体外和体内检测的新方法。 本发明基于蛋白质互补，其中两个单独的多肽是无活性的。 当两个无活性多肽片段在与靶核酸杂交期间紧密接近时，它们重新连接成活性的可检测蛋白质。

    NUCLEIC ACID SUPPORTED PROTEIN COMPLEMENTATION
    27.
    发明申请
    NUCLEIC ACID SUPPORTED PROTEIN COMPLEMENTATION 有权
    核酸支持蛋白质补充

    公开(公告)号：US20100297629A1

    公开(公告)日：2010-11-25

    申请号：US12638871

    申请日：2009-12-15

    Applicant: Charles R. Cantor ,  Natalia E. Broude ,  Carlos Witte-Hoffman

    Inventor： Charles R. Cantor ,  Natalia E. Broude ,  Carlos Witte-Hoffman

    IPC: C12Q1/68 ,  C07K9/00

    CPC classification number: C12Q1/6818 ,  C12Q1/6813 ,  C12Q2563/131 ,  C12Q2561/107

    Abstract: The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When the two inactive polypeptide fragment are brought in close proximity during hybridization to a target nucleic acid, they re-associate into an active, detectable protein.

    Abstract translation: 本发明涉及用于靶核酸分子（包括DNA和RNA靶标）以及核酸类似物的体外和体内检测的新方法。 本发明基于蛋白质互补，其中两个单独的多肽是无活性的。 当两个无活性多肽片段在与靶核酸杂交期间紧密接近时，它们重新连接成活性的可检测蛋白质。

    Nucleic acid supported protein complementation
    28.
    发明授权
    Nucleic acid supported protein complementation 有权
    核酸支持的蛋白质互补

    公开(公告)号：US07662554B2

    公开(公告)日：2010-02-16

    申请号：US10529122

    申请日：2003-10-09

    Applicant: Charles R. Cantor ,  Natalia E. Broude ,  Carlos Witte-Hoffmann

    Inventor： Charles R. Cantor ,  Natalia E. Broude ,  Carlos Witte-Hoffmann

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6818 ,  C12Q1/6813 ,  C12Q2563/131 ,  C12Q2561/107

    Abstract: The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When the two inactive polypeptide fragment are brought in close proximity during hybridization to a target nucleic acid, they re-associate into an active, detectable protein.

    Abstract translation: 本发明涉及用于靶核酸分子（包括DNA和RNA靶标）以及核酸类似物的体外和体内检测的新方法。 本发明基于蛋白质互补，其中两个单独的多肽是无活性的。 当两个无活性多肽片段在与靶核酸杂交期间紧密接近时，它们重新连接成活性的可检测蛋白质。

    Streptavidin proteins
    30.
    发明授权
    Streptavidin proteins 失效
    链霉亲和素蛋白

    公开(公告)号：US07179618B2

    公开(公告)日：2007-02-20

    申请号：US10285876

    申请日：2002-11-01

    Applicant: Takeshi Sano ,  Alexander N. Glazer ,  Charles R. Cantor

    Inventor： Takeshi Sano ,  Alexander N. Glazer ,  Charles R. Cantor

    IPC: C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C12P21/06

    CPC classification number: C07H21/04 ,  C07K14/36 ,  C07K14/825 ,  C07K2319/00 ,  C07K2319/22

    Abstract: Streptavidin-metallothionein chimeric proteins with biological recognition specificity in which the streptavidin moiety provides high affinity biotin binding and the metallothionein moiety provides a high affinity metal binding. The binding affinity of the streptavidin-metallothionein chimeric protein both for biotin and heavy metal ions allows specific incorporation into, conjugation with, or labelling of any biological material containing biotin with various heavy metal ions.

    Abstract translation: 具有生物识别特异性的链霉亲和素 - 金属硫蛋白嵌合蛋白，其中链霉亲和素部分提供高亲和力生物素结合和金属硫蛋白部分提供高亲和力的金属结合。 链霉抗生物素蛋白 - 金属硫蛋白嵌合蛋白对生物素和重金属离子的结合亲和力允许特异性掺入，缀合或标记含有生物素与各种重金属离子的任何生物材料。

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