Abstract:
Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
Abstract:
Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
Abstract:
An apparatus is provided for combined ergonomic support and situational sensory augmentation interface during an interactive session within a virtual environment generated by a computer system. The apparatus comprises a resilient body defining a mid portion extending laterally between a pair of side portions projecting transversely outward therefrom to terminate at respective free ends. The mid portion extends across a lap of a user. The mid and side portions collectively define an upper surface for hand and forearm support for the user and an inner side surface contoured about a cradle space for receiving a torso of the user in cradling manner. At least one actuator disposed on the resilient body is selectively driven in cooperation with the interactive session to generate tactile feedback to the user through at least one of the upper and inner side surfaces of the resilient body.
Abstract:
A semiconductor device including a doped substrate of a first doping polarity and a doped semiconductor material of a second doping polarity. The semiconductor material is on, or in, the substrate, and the second doping polarity is opposite the first doping polarity such that the semiconductor material and the substrate form a diode. The semiconductor device further includes an inductor on or above the semiconductor material, and a pattern in the semiconductor material for reducing eddy currents. The pattern includes a doped semiconductor material of the first doping polarity and a least one trench within the doped semiconductor material of the first doping polarity, wherein, at least at a depth at which the trench is closest to the inductor, the doped semiconductor material of the first doping polarity fully surrounds the trench so that, at least at the depth, the trench does not touch the doped semiconductor material of the second doping polarity.
Abstract:
A method and apparatus for the casting of metal components is disclosed. The apparatus includes a gooseneck for drawing molten metal from a crucible of hot metal and for forcing the drawn molten metal through the system, a hot runner assembly having a hot runner tip positioned adjacent the mold cavity, and a machine nozzle inserted between the gooseneck and the hot runner assembly. The gooseneck is fitted with a one-way check valve to allow for molten metal to be drawn into the plunger but to stop its passage out of the gooseneck when the metal is forced through the system into the die. A thermal valve is formed within the hot runner tip to provide a metal blockage from the molten metal which prevents the back-flow of molten metal back into the hot runner assembly. Both temperature and flow rate are carefully monitored and controlled.
Abstract:
A method is provided that includes transmitting a video stream to a set-top box. The video stream may include a targeted advertisement with a user selectable indicator to identify supplemental video content related to the targeted advertisement based on a subscriber profile associated with the set-top box. The method further includes receiving a request from the set-top box based on the user selectable indicator and transmitting the supplemental video content to a memory of the set-top box independently from the video stream and without interrupting display of the video stream.
Abstract:
The present disclosure is directed to a system and method of providing targeted advertisements. In a particular embodiment, the method includes receiving video content of television programming at a set-top box device from a video server of an Internet Protocol Television (IPTV) system. The method also includes receiving video content of a targeted advertisement at the set-top box device from the video server with the video content of the television programming, where an advertisement server of the IPTV system selects the targeted advertisement based on a customer profile associated with an identifier of the set-top box device. The method also includes recognizing an advertisement insertion point in the video content of the television programming. The method also includes inserting the video content of the targeted advertisement into the video content of the television programming at the advertisement insertion point.
Abstract:
A locker for securing one or more tensioning members includes a locker body having a first aperture, a second aperture, and a passageway extending therebetween. A pin is coupled to the locker body so as to traverse the passageway and is movable between a latent condition wherein the tensioning members are movable with respect to the locker body, and an activated condition wherein the tensioning members are prevented from moving relative to the locker body. A method of using a suture locker includes delivering the suture locker to a surgical site via a catheter assembly and actuating the pin so as to move the locker from the latent condition to the activated condition.
Abstract:
The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.