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    HEPARIN-CONJUGATED FIBRIN GEL AND METHOD AND KIT FOR PREPARING SAME
    21.
    发明申请
    HEPARIN-CONJUGATED FIBRIN GEL AND METHOD AND KIT FOR PREPARING SAME 审中-公开
    HEPARIN-CONJUGATED FIBRIN GEL AND METHOD AND KIT FOR PREPARTING SAME

    公开(公告)号：US20110091443A1

    公开(公告)日：2011-04-21

    申请号：US12990121

    申请日：2009-04-28

    申请人： Byung-Soo Kim ,  O-Ju Jeon ,  Hee-Seok Yang

    发明人： Byung-Soo Kim ,  O-Ju Jeon ,  Hee-Seok Yang

    IPC分类号： A61K38/48 ,  A61K38/18 ,  A61P17/02 ,  A61P19/08 ,  A61P9/10

    CPC分类号： A61L27/225 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/802

    摘要： A method of preparing a heparin-conjugated fibrin gel is provided, which includes activating heparin, conjugating the activated heparin with fibrinogen to prepare heparin-conjugated fibrinogen, mixing free fibrinogen with the heparin-conjugated fibrinogen to prepare a fibrinogen mixture, and mixing thrombin with the fibrinogen mixture. In addition, a heparin-conjugated fibrin gel prepared by the above method and a kit for preparing the same are provided. According to the method of preparing the heparin-conjugated fibrin gel, the heparin-conjugated fibrin gel having an affinity for drugs such as growth factors may be easily prepared at low costs, and can also be used as a therapeutic drug excellently effective on generation of tissues such as bones, skin, blood vessels, cartilages, etc. by sustainably releasing drugs such as growth factors to a local site for a long period of time through injection into a human body.

    摘要翻译： 提供了一种制备肝素结合的纤维蛋白凝胶的方法，其包括激活肝素，将活化的肝素与纤维蛋白原缀合以制备肝素缀合的纤维蛋白原，将免疫纤维蛋白原与肝素缀合的纤维蛋白原混合以制备纤维蛋白原混合物，并将凝血酶与 纤维蛋白原混合物。 此外，提供通过上述方法制备的肝素缀合的纤维蛋白凝胶和其制备用试剂盒。 根据制备肝素结合的纤维蛋白凝胶的方法，可以容易地以低成本制备对诸如生长因子的药物具有亲和力的肝素缀合的纤维蛋白凝胶，并且还可以用作在产生 组织如骨骼，皮肤，血管，软骨等，通过将人体可持续释放药物如生长因子长时间地注射到局部部位。

    HEAD STACK ASSEMBLY AND HARD DISK DRIVE HAVING THE SAME
    22.
    发明申请
    HEAD STACK ASSEMBLY AND HARD DISK DRIVE HAVING THE SAME 审中-公开
    头架组装和硬盘驱动器

    公开(公告)号：US20100246070A1

    公开(公告)日：2010-09-30

    申请号：US12749706

    申请日：2010-03-30

    申请人： Jung Moo SON ,  Byung-Soo Kim

    发明人： Jung Moo SON ,  Byung-Soo Kim

    IPC分类号： G11B5/55

    CPC分类号： G11B5/54 ,  G11B5/6005

    摘要： A hard disk drive includes a head stack assembly including a read/write head mounted thereon and an actuator arm pivoting over a disk around a pivot shaft installed on a base, a pivot shaft holder rotatably supporting the pivot shaft and to which the actuator arm is coupled, and a bobbin provided at the opposite side of the actuator arm with respect to the pivot shaft holder and having a voice coil motor coil installed on at least one surface thereof, a crash stop coupled to the base and restricting displacement of the actuator arm, and a contact area reduction portion provided on at least one of the bobbin and the crash stop and including at least one non-contact section, in which the bobbin and the crash stop do not contact each other, in a contact section of the bobbin and the crash stop, when the bobbin and crash stop contact each other, to reduce the contact area between the bobbin and the crash stop.

    摘要翻译： 一个硬盘驱动器包括一个磁头堆叠组件，包括一个安装在其上的读/写磁头和一个致动器臂，该致动器臂围绕安装在基座上的枢转轴围绕一个磁盘枢转，枢轴保持器可旋转地支撑枢转轴，致动器臂 以及设置在所述致动器臂相对于所述枢转轴保持器的相对侧并且具有安装在其至少一个表面上的音圈电动机线圈的线轴;联接到所述基座的限位器，并限制所述致动器臂 以及设置在所述筒管和所述紧急停止装置中的至少一个上的接触区域缩小部分，并且在所述筒管的接触部分中包括至少一个所述筒管和所述紧急停止件彼此不接触的非接触部分 并且当线轴和碰撞停止器彼此接触时，碰撞停止，以减小线轴与碰撞停止之间的接触面积。

    PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same
    23.
    发明申请
    PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same 审中-公开
    PLGA /羟基磷灰石复合材料及其制备方法

    公开(公告)号：US20090048358A1

    公开(公告)日：2009-02-19

    申请号：US12279172

    申请日：2007-03-06

    申请人： Byung-Soo Kim

    发明人： Byung-Soo Kim

    IPC分类号： A61F2/02 ,  C08J9/35 ,  B29C43/00

    CPC分类号： A61L27/56 ,  A61L27/44 ,  A61L27/46 ,  A61L2400/12 ,  A61L2430/02 ,  C08L67/04

    摘要： Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

    摘要翻译： 组织工程是一个不断发展的领域，新材料正在开发用于植入人体。 一个重要的领域涉及骨移植材料来代替创伤或疾病损失的骨骼部位。 传统上，可以从接受移植材料的个体的骨中收获移植材料。 然而，这需要额外的手术和额外的恢复。 骨头也可能来自其他人，甚至是尸体，但这会引起生物相容性问题以及疾病转移的风险。 理想地，寻求一种生物相容性材料，其将充当具有适当机械强度的填充物，促进骨骼愈合，并降解以允许新的骨向内生长而没有疾病转移的风险。 本发明是由生物相容性聚（D，L-乳酸 - 共 - 乙醇酸）（PLGA）和使用气泡发泡颗粒浸出（GF / PL）在其表面上暴露的纳米级羟基磷灰石颗粒制成的新型复合骨移植材料， 方法。 本发明的另一个实施方案涉及用粘附剂，快速均匀的矿物如磷灰石涂层来涂覆该PLGA /羟基磷灰石生物材料。 复合材料的PLGA聚合物部分提供了足够的机械强度来代替骨骼，并随着时间推移可降解，以允许新的骨组织向内生长。 掺入的羟基磷灰石颗粒通过提供用于组织附着和繁殖的位点增加复合材料的成骨性质。 最后，在这种新型生物材料复合材料表面上均匀地涂覆矿物磷灰石，进一步增强了其成骨质量。

    PLGA/hydroxyapatite composite biomaterial and method of making the same
    24.
    发明申请
    PLGA/hydroxyapatite composite biomaterial and method of making the same 有权
    PLGA /羟基磷灰石复合生物材料及其制备方法

    公开(公告)号：US20080065228A1

    公开(公告)日：2008-03-13

    申请号：US11714507

    申请日：2007-05-22

    申请人： Byung-Soo Kim

    发明人： Byung-Soo Kim

    IPC分类号： A61F2/28 ,  B29C39/02

    CPC分类号： A61L27/56 ,  A61L27/44 ,  A61L27/46 ,  A61L2400/12 ,  A61L2430/02 ,  C08L67/04

    摘要： Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

    摘要翻译： 组织工程是一个不断发展的领域，新材料正在开发用于植入人体。 一个重要的领域涉及骨移植材料来代替创伤或疾病损失的骨骼部位。 传统上，可以从接受移植材料的个体的骨中收获移植材料。 然而，这需要额外的手术和额外的恢复。 骨头也可能来自其他人，甚至是尸体，但这会引起生物相容性问题以及疾病转移的风险。 理想地，寻求一种生物相容性材料，其将充当具有适当机械强度的填充物，促进骨骼愈合，并降解以允许新的骨向内生长而没有疾病转移的风险。 本发明是由生物相容性聚（D，L-乳酸 - 共 - 乙醇酸）（PLGA）和使用气泡发泡颗粒浸出（GF / PL）在其表面上暴露的纳米级羟基磷灰石颗粒制成的新型复合骨移植材料， 方法。 本发明的另一个实施方案涉及用粘附剂，快速均匀的矿物如磷灰石涂层来涂覆该PLGA /羟基磷灰石生物材料。 复合材料的PLGA聚合物部分提供了足够的机械强度来代替骨骼，并随着时间推移可降解，以允许新的骨组织向内生长。 掺入的羟基磷灰石颗粒通过提供用于组织附着和繁殖的位点增加复合材料的成骨性质。 最后，在这种新型生物材料复合材料表面上均匀地涂覆矿物磷灰石，进一步增强了其成骨质量。

    Hybrid tissues for tissue engineering
    26.
    发明申请
    Hybrid tissues for tissue engineering 审中-公开
    组织工程杂交组织

    公开(公告)号：US20050002982A1

    公开(公告)日：2005-01-06

    申请号：US10726072

    申请日：2003-12-01

    申请人： David Mooney ,  Charles Vacanti ,  Craig Halberstadt ,  Andrea Ferguson ,  Jennifer Marler ,  Byung-Soo Kim

    发明人： David Mooney ,  Charles Vacanti ,  Craig Halberstadt ,  Andrea Ferguson ,  Jennifer Marler ,  Byung-Soo Kim

    IPC分类号： A61K35/12 ,  A61K48/00 ,  A61L27/38 ,  C12N5/071

    CPC分类号： A61L27/3886 ,  A61K35/12 ,  A61K48/00 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  C12N5/0697 ,  C12N2502/1317 ,  C12N2502/28 ,  C12N2533/40

    摘要： The present invention comprises an implantable device that provides artificial tissues for repair, augmentation and reconstructive surgery which have mechanical properties comparable to the natural tissues that they supplement or replace. Such devices can be produced by a tissue engineering method comprising seeding a polymer matrix with a first cell type and a second cell type and culturing the seeded matrix under conditions suitable for cell growth or maintenance, whereby a tissue comprising a mixed cell population containing both the first and second cell types is produced. The tissue produced by this method contains a mixed population in which the two cell types are intimately associated without apparent stratification and has mechanical properties which are intermediate between similarly produced tissues containing either one of the two cell types. This invention is particularly useful in forming implantable structural members.

    摘要翻译： 本发明包括可植入装置，其提供用于修复，增加和重建手术的人造组织，其具有与其补充或替代的天然组织相当的机械性能。 这样的装置可以通过组织工程方法来生产，包括将具有第一种细胞类型和第二种细胞类型的聚合物基质接种，并在适于细胞生长或维持的条件下培养接种的基质，由此将包含混合细胞群的组织 产生第一和第二细胞类型。 通过该方法产生的组织包含混合群体，其中两种细胞类型密切相关而没有明显的分层，并且具有在含有两种细胞类型之一的类似产生的组织之间中间的机械性质。 本发明特别可用于形成可植入结构构件。

    Content update feature for an instant messaging service
    29.
    发明授权
    Content update feature for an instant messaging service 有权
    即时通讯服务的内容更新功能

    公开(公告)号：US07734702B2

    公开(公告)日：2010-06-08

    申请号：US11327534

    申请日：2006-01-05

    申请人： Byung-Soo Kim

    发明人： Byung-Soo Kim

    IPC分类号： G06F15/16

    CPC分类号： H04L51/04

    摘要： A first mobile terminal comprising a screen configured to display a first window for displaying messages communicated between the first terminal and a second terminal; a user interface, wherein a user may interact with the user interface to update content in a first message displayed in the first window, wherein the first message is previously communicated to and displayed on the second terminal; a processor for detecting updated information and constructing an update packet comprising information about the updated information; and a transmitter for transmitting the update packet to the second terminal to cause a corresponding content update in the first message previously displayed on the second terminal.

    摘要翻译： 一种第一移动终端，包括被配置为显示用于显示在第一终端和第二终端之间传送的消息的第一窗口的屏幕; 用户界面，其中用户可以与所述用户界面交互以更新在所述第一窗口中显示的第一消息中的内容，其中所述第一消息先前传达到并显示在所述第二终端上; 用于检测更新信息并构造包括关于更新信息的信息的更新分组的处理器; 以及发送器，用于将所述更新分组发送到所述第二终端，以在所述第二终端上预先显示的所述第一消息中引起相应的内容更新。