公开(公告)号：US20170157418A1

公开(公告)日：2017-06-08

申请号：US15434871

申请日：2017-02-16

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark OLDHAM ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Harold WALDER ,  Frederic A. BOURKE, JR. ,  Mark DEWHIRST ,  Neil L. SPECTOR ,  Paul YOON ,  Justus ADAMSON ,  David ALCORTA ,  Kim LYERLY ,  Leihua LIU ,  Takuya OSADA

IPC分类号： A61N5/06 ,  A61K31/352 ,  A61K41/00 ,  A61N5/10

CPC分类号： A61N5/062 ,  A61K31/352 ,  A61K31/525 ,  A61K33/00 ,  A61K35/00 ,  A61K38/00 ,  A61K41/0066 ,  A61N5/10 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1089 ,  A61N2005/1098

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.

公开(公告)号：US20170050046A1

公开(公告)日：2017-02-23

申请号：US15307766

申请日：2015-04-22

申请人： IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY ,  NORTH CAROLINA STATE UNIVERSITY

发明人： Harold WALDER ,  Frederic A. BOURKE ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Mark W. DEWHIRST ,  Mark OLDHAM ,  Justus ADAMSON ,  Michael NOLAN

IPC分类号： A61N5/06 ,  A61B6/00 ,  A61N5/10 ,  A61K9/00 ,  A61K49/04 ,  A61K41/00 ,  A61K39/00 ,  A61B6/03 ,  A61N5/02

CPC分类号： A61N5/062 ,  A61K39/0011 ,  A61K41/0019 ,  A61K41/0066 ,  A61K49/0423 ,  A61K2039/585 ,  A61N5/022 ,  A61N5/10 ,  A61N5/1081 ,  A61N2005/0627 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1089 ,  A61N2005/1098

摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photo-activatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

摘要翻译： 用于在人或动物体内成像或治疗疾病的系统和方法。 该系统向人体或动物体提供包含能够将紫外线或可见光发射到体内并提供x射线对比度的一种或多种磷光体的药物载体。 该系统包括一个或多个装置，其将病变部位注入可光活化药物和药物载体，引发能量源包括用X射线或高能量源照射患病部位的x射线， 伽马射线或电子，从而开始将所述紫外线或可见光发射到体内;以及处理器，被编程为以下中的至少一个：1）产生患病部位的图像，或2）控制所述X射线，γ射线的剂量 或电子到病变部位，以在病变部位产生所述紫外线或可见光，以活化可光活化药物。

公开(公告)号：US20170043178A1

公开(公告)日：2017-02-16

申请号：US15247367

申请日：2016-08-25

申请人： IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

发明人： Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian Nicholas STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John NORTON

IPC分类号： A61N5/06 ,  A61N5/10 ,  A61L2/00 ,  A61B5/055 ,  A61B6/00 ,  A61K41/00 ,  A61M5/00 ,  A61B5/00

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

摘要翻译： 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US20150251016A1

公开(公告)日：2015-09-10

申请号：US14716394

申请日：2015-05-19

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian Nicholas STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John NORTON

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

摘要翻译： 用于修改目标结构的产品，组成，系统和方法。 所述方法可以以非侵入性方式进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并施加引发能量，从而产生作用或改变 目标结构直接或通过调制剂。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过施加起始能量来直接地或经由能量调节剂，任选地在一种或多种等离子体激元活性剂的存在下活化可光活化剂，从而对目标结构产生影响或改变。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US20220315809A1

公开(公告)日：2022-10-06

申请号：US17433734

申请日：2020-02-27

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： C09J133/08

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.

公开(公告)号：US20220181292A1

公开(公告)日：2022-06-09

申请号：US17647275

申请日：2022-01-06

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae FATHI ,  James CLAYTON ,  Harold WALDER ,  Frederic A. BOURKE, JR.

IPC分类号： H01L23/00 ,  C08K3/00 ,  B41J2/175 ,  C09J4/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18 ,  B32B38/00 ,  C09J133/08 ,  C09K11/02 ,  C09K11/77 ,  H01L25/065 ,  H01L25/00 ,  B32B3/26 ,  B32B7/14 ,  B32B9/04 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  H01L23/522

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US20220146076A1

公开(公告)日：2022-05-12

申请号：US17433827

申请日：2020-02-27

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Daniel I. BECKER ,  Joseph H. SIMMONS

IPC分类号： F21V9/30 ,  H01L31/06 ,  H01L31/0352 ,  F21S11/00 ,  F21V9/40

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, especially in the field of solar cells and other energy conversion devices.

公开(公告)号：US20220134131A1

公开(公告)日：2022-05-05

申请号：US17433911

申请日：2020-02-28

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： A61N5/06 ,  A61K41/00

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields.

公开(公告)号：US20200215611A1

公开(公告)日：2020-07-09

申请号：US16819806

申请日：2020-03-16

申请人： IMMUNOLIGHT, LLC.

发明人： Zakaryae FATHI ,  James CLAYTON ,  Harold WALDER ,  Frederic A. BOURKE, JR.

IPC分类号： B22F3/105 ,  B33Y30/00 ,  B23K26/354 ,  B33Y10/00 ,  B22F7/06 ,  B23K26/34 ,  B33Y80/00 ,  B33Y50/02 ,  B22F5/04

摘要： A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US20190022221A1

公开(公告)日：2019-01-24

申请号：US15543297

申请日：2016-01-13

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic Avery BOURKE ,  Harold WALDER

IPC分类号： A61K41/00

摘要： Products, compositions, systems, and methods for treating a subject carrying a virus or bacterium. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to the subject thus producing an effect on or change to a target structure of the subject directly or indirectly. The methods may further be performed by application of an initiation energy to a subject to activate within the subject a photoactivatable drug directly or indirectly, optionally in the presence of one or more plasmonics active agents, thus treating the virus or bacterium. Also provided are kits containing products or compositions formulated or configured and systems for use in practicing these methods.